A genome on shaky ground: exploring the impact of mitochondrial DNA integrity on Parkinson’s disease by highlighting the use of cybrid models Martin LangAnne GrünewaldIrene Pichler Review Open access 05 May 2022 Article: 283
Lipid-induced monokine cyclophilin-A promotes adipose tissue dysfunction implementing insulin resistance and type 2 diabetes in zebrafish and mice models of obesity Dipanjan BanerjeeDebarun PatraSuman Dasgupta Original Article 05 May 2022 Article: 282
The mechanism of activation of MEK1 by B-Raf and KSR1 Ryan C. MaloneyMingzhen ZhangRuth Nussinov Original Article Open access 04 May 2022 Article: 281
Disruption of ZNF334 promotes triple-negative breast carcinoma malignancy through the SFRP1/ Wnt/β-catenin signaling axis Zhaobo ChengRenjie YuTingxiu Xiang Original Article 04 May 2022 Article: 280
PUMILIO-mediated translational control of somatic cell cycle program promotes folliculogenesis and contributes to ovarian cancer progression Xin LiMengyi ZhuEugene Yujun Xu Original Article 04 May 2022 Article: 279
SRF depletion in early life contributes to social interaction deficits in the adulthood Matylda RoszkowskaAnna KrysiakKatarzyna Kalita Original Article Open access 04 May 2022 Article: 278
GHSR controls food deprivation-induced activation of CRF neurons of the hypothalamic paraventricular nucleus in a LEAP2-dependent manner Gimena FernandezAgustina CabralMario Perello Original Article 04 May 2022 Article: 277
New insights into the molecular mechanisms of ROR1, ROR2, and PTK7 signaling from the proteomics and pharmacological modulation of ROR1 interactome Juuli RaivolaAlice DiniDaniela Ungureanu Original Article Open access 04 May 2022 Article: 276
Trafficking and retention of protein antigens across systems and immune cell types Thu A. DoanTadg ForwardBeth A. Jirón Tamburini Review 03 May 2022 Article: 275
Modifier pathways in polyglutamine (PolyQ) diseases: from genetic screens to drug targets Marta Daniela CostaPatrícia Maciel Review 03 May 2022 Article: 274
Anti-inflammatory effect of SGLT-2 inhibitors via uric acid and insulin Rosalba La GrottaPaola de CandiaFrancesco Prattichizzo Original Article Open access 03 May 2022 Article: 273
Adipokines, adiposity, and atherosclerosis Longhua LiuZunhan ShiLi Qiang Review 03 May 2022 Article: 272
Nucleolin: a cell portal for viruses, bacteria, and toxins Fiorella TonelloMaria Lina MassiminoCaterina Peggion Review Open access 03 May 2022 Article: 271
RIP140 inhibits glycolysis-dependent proliferation of breast cancer cells by regulating GLUT3 expression through transcriptional crosstalk between hypoxia induced factor and p53 Valentin JacquierDelphine GitenayCatherine Teyssier Original Article Open access 03 May 2022 Article: 270
Soluble RAGE attenuates myocardial I/R injuries via FoxO3–Bnip3 pathway Jie ZhangXuejie HanCaixia Guo Original Article 02 May 2022 Article: 269
FBXW2 inhibits prostate cancer proliferation and metastasis via promoting EGFR ubiquitylation and degradation Tao ZhouTingting ChenJie Xu Original Article Open access 02 May 2022 Article: 268
Cutaneous nerve fibers participate in the progression of psoriasis by linking epidermal keratinocytes and immunocytes Si-Qi ChenXue-Yan ChenXiao-Yong Man Original Article 30 April 2022 Article: 267
Hedgehog signaling and its molecular perspective with cholesterol: a comprehensive review Jyoti B. KaushalSurinder K. BatraSatyanarayana Rachagani Review 29 April 2022 Article: 266
Impaired regulation of PMCA activity by defective CFTR expression promotes epithelial cell damage in alcoholic pancreatitis and hepatitis Tamara MadácsyÁrpád VargaJózsef Maléth Original Article 28 April 2022 Article: 265
SMAlow/undetectable pericytes differentiate into microglia- and macrophage-like cells in ischemic brain Abhijit NirwaneYao Yao Original Article 28 April 2022 Article: 264
Listeria monocytogenes exposed to antimicrobial peptides displays differential regulation of lipids and proteins associated to stress response Paolo StinconeFlávio Fonseca VerasAdriano Brandelli Original Article 28 April 2022 Article: 263
Calpains as novel players in the molecular pathogenesis of spinocerebellar ataxia type 17 Jonasz Jeremiasz WeberStefanie Cari AngerHuu Phuc Nguyen Original Article Open access 28 April 2022 Article: 262
CYP311A1 in the anterior midgut is involved in lipid distribution and microvillus integrity in Drosophila melanogaster Wei DongXubo ZhangJianzhen Zhang Original Article 28 April 2022 Article: 261
CEMIP (KIAA1199) regulates inflammation, hyperplasia and fibrosis in osteoarthritis synovial membrane Céline DeroyerChristophe PouletDominique de Seny Original Article Open access 27 April 2022 Article: 260
Effective high-throughput isolation of enriched platelets and circulating pro-angiogenic cells to accelerate skin-wound healing Silvia ErraticoMarzia BelicchiYvan Torrente Original Article Open access 26 April 2022 Article: 259
Impaired primordial follicle assembly in offspring ovaries from zearalenone-exposed mothers involves reduced mitochondrial activity and altered epigenetics in oocytes Yan-Qin FengJun-Jie WangWei Shen Original Article 26 April 2022 Article: 258
Downregulation of epithelial sodium channel (ENaC) activity in cystic fibrosis cells by epigenetic targeting Giovanna BlaconàRoberto RasoMarco Lucarelli Original Article Open access 25 April 2022 Article: 257
Skeletal muscle cell-specific differences in type 2 diabetes Noni T. FrankenbergShaun A. MasonRobyn M. Murphy Original Article Open access 23 April 2022 Article: 256
uPARAP/Endo180: a multifaceted protein of mesenchymal cells Fabrice GucciardoSébastien PirsonAgnès Noël Review Open access 22 April 2022 Article: 255
Hotair promotes the migration and proliferation in ovarian cancer by miR-222-3p/CDK19 axis Lili FanHan LeiGang Yin Original Article Open access 22 April 2022 Article: 254
CircACTR2 in macrophages promotes renal fibrosis by activating macrophage inflammation and epithelial–mesenchymal transition of renal tubular epithelial cells Hua FuYong-Hong GuGuo-Hui Wang Original Article 21 April 2022 Article: 253
The human dental apical papilla promotes spinal cord repair through a paracrine mechanism P. De BerdtK. VanvarenbergA. des Rieux Original Article 21 April 2022 Article: 252
Liquid–liquid phase separation as an organizing principle of intracellular space: overview of the evolution of the cell compartmentalization concept Iuliia A. AntifeevaAlexander V. FoninKonstantin K. Turoverov Review 20 April 2022 Article: 251
Galectin-3 interferes with tissue repair and promotes cardiac dysfunction and comorbidities in a genetic heart failure model Fani VlachouAimilia VarelaStelios Psarras Original Article 19 April 2022 Article: 250
Traumatic-noise-induced hair cell death and hearing loss is mediated by activation of CaMKKβ Fan WuKayla HillSu-Hua Sha Original Article 19 April 2022 Article: 249
PI(4,5)P2 controls slit diaphragm formation and endocytosis in Drosophila nephrocytes Maximilian M. GassSarah BorkowskyMichael P. Krahn Original Article Open access 18 April 2022 Article: 248
Platelets fine-tune effector responses of naïve CD4+ T cells via platelet factor 4-regulated transforming growth factor β signaling Yanan MinLong HaoNailin Li Original Article Open access 18 April 2022 Article: 247
Molecular mechanisms of aberrant neutrophil differentiation in glycogen storage disease type Ib Sang Wan SimYuyeon JangHyun Sik Jun Original Article 18 April 2022 Article: 246
Experimental colonization with Blastocystis ST4 is associated with protective immune responses and modulation of gut microbiome in a DSS-induced colitis mouse model Lei DengLukasz WojciechKevin Shyong Wei Tan Original Article Open access 18 April 2022 Article: 245
The extracellular matrix molecule tenascin-C modulates cell cycle progression and motility of adult neural stem/progenitor cells from the subependymal zone Elena SchabergMagdalena GötzAndreas Faissner Original Article Open access 16 April 2022 Article: 244
The role of bile acids in carcinogenesis Tadeja ReženDamjana RozmanEdit Mikó Review Open access 16 April 2022 Article: 243
Molecular dissection on inhibition of Ras-induced cellular senescence by small t antigen of SV40 Dongsheng ShangTianchu ZhouZhigang Tu Original Article 16 April 2022 Article: 242
Interaction of ToLCNDV TrAP with SlATG8f marks it susceptible to degradation by autophagy Ashish PrasadManoj Prasad Original Article 15 April 2022 Article: 241
Novel contact–kinin inhibitor sylvestin targets thromboinflammation and ameliorates ischemic stroke Zhiye ZhangChuanbin ShenRen Lai Original Article 13 April 2022 Article: 240
Mitochondrial function in spinal cord injury and regeneration Paula G. SlaterMiguel E. Domínguez-RomeroJuan Larraín Review 13 April 2022 Article: 239
Two distinct males absent on the first (MOF)-containing histone acetyltransferases are involved in the epithelial–mesenchymal transition in different ways in human cells Tao WeiHongsen LiuJingji Jin Original Article 13 April 2022 Article: 238
The E3 ubiquitin ligase SMURF2 stabilizes RNA editase ADAR1p110 and promotes its adenosine-to-inosine (A-to-I) editing function Praveen KogantiVenkata Narasimha KadaliMichael Blank Original Article 11 April 2022 Article: 237
MALL, a membrane-tetra-spanning proteolipid overexpressed in cancer, is present in membraneless nuclear biomolecular condensates Armando Rubio-RamosMiguel Bernabé-RubioMiguel A. Alonso Original Article Open access 10 April 2022 Article: 236
Rapid shear stress-dependent ENaC membrane insertion is mediated by the endothelial glycocalyx and the mineralocorticoid receptor Zülfü C. CosgunMagdalena SternakKristina Kusche-Vihrog Original Article Open access 10 April 2022 Article: 235
A53T mutant α-synuclein fibrils formed in macrophage are spread to neurons Shogo MoriyaMichiko HanazonoMasaki Takiguchi Original Article 10 April 2022 Article: 234
