Epigenetic drugs- from chemistry via biology to medicine and back

In this topical collection (13 articles)

1. Review

   Genome-wide epigenomic profiling for biomarker discovery

   René A. M. Dirks, Hendrik G. Stunnenberg, Hendrik Marks Article:122

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2. Review

   Epigenetic polypharmacology: from combination therapy to multitargeted drugs

   Angel R. de Lera, A. Ganesan Article:105

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3. Review

   The emerging role of lysine methyltransferase SETD8 in human diseases

   Ciro Milite, Alessandra Feoli, Monica Viviano, Donatella Rescigno… Article:102

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4. Review

   Epigenetic modulators as therapeutic targets in prostate cancer

   Inês Graça, Eva Pereira-Silva, Rui Henrique, Graham Packham… Article:98

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5. Review

   Studying epigenetic complexes and their inhibitors with the proteomics toolbox

   David Weigt, Carsten Hopf, Guillaume Médard Article:76

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6. Review

   A clinical-molecular update on azanucleoside-based therapy for the treatment of hematologic cancers

   Jeannine Diesch, Anabel Zwick, Anne-Kathrin Garz, Anna Palau… Article:71

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7. Review

   Epigenetic mechanisms during ageing and neurogenesis as novel therapeutic avenues in human brain disorders

   Raúl Delgado-Morales, Roberto Carlos Agís-Balboa, Manel Esteller… Article:67

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8. Review

   Sirtuin functions and modulation: from chemistry to the clinic

   Vincenzo Carafa, Dante Rotili, Mariantonietta Forgione… Article:61

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9. Review

   Histone acetyltransferases: challenges in targeting bi-substrate enzymes

   Hannah Wapenaar, Frank J. Dekker Article:59

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10. Review

    Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy

    Ludovica Morera, Michael Lübbert, Manfred Jung Article:57

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11. Editorial

    Epigenetic drugs: from chemistry via biology to medicine and back

    Lucia Altucci, Marianne G. Rots Article:56

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12. Review

    Polycomb repressive complex’s evolutionary conserved function: the role of EZH2 status and cellular background

    Koraljka Gall Trošelj, Renata Novak Kujundzic, Djurdjica Ugarkovic Article:55

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13. Review

    Epigenetic strategies to reverse drug resistance in heterogeneous multiple myeloma

    Mark E. Issa, Farnaz Sedigheh Takhsha, Chandra Sekhar Chirumamilla… Article:17

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