1. Preface

   • Frank Norbert Gellerich
   • Stephan Zierz

   Legacy Pages: 1 - 3

2. Diagnosis of defects in oxidative muscle metabolism by non-invasive tissue oximetry

   • William Bank
   • Britton Chance

   OriginalPaper Pages: 7 - 10

3. In vivo assessment of human skeletal muscle mitochondria respiration in health and disease

   • Bruno Barbiroli
   • Stefano Iotti
   • Raffaele Lodi

   OriginalPaper Pages: 11 - 15

4. Non-invasive quantitative ³¹P MRS assay of mitochondrial function in skeletal muscle in situ

   • Jeroen A.L. Jeneson
   • Robert W. Wiseman
   • Martin J. Kushmerick

   OriginalPaper Pages: 17 - 22

5. Phosphorus metabolite distribution in skeletal muscle: Quantitative bioenergetics using creatine analogs

   • Robert W. Wiseman
   • M. J. Kushmerick

   OriginalPaper Pages: 23 - 28

6. A theoretical model of some spatial and temporal aspects of the mitochondrion creatine kinase myofibril system in muscle

   • G.J. Kemp
   • D.N. Manners
   • G.K. Radda

   OriginalPaper Pages: 29 - 32

7. Fluxes through cytosolic and mitochondrial creatine kinase, measured by P-31 NMR

   • Ferdi A. van Dorsten
   • Torsten Reese
   • Klaas Nicolay

   OriginalPaper Pages: 33 - 42

8. Experimental evidence for dynamic compartmentation of ADP at the mitochondrial periphery: Coupling of mitochondrial adenylate kinase and mitochondrial hexokinase with oxidative phosphorylation under conditions mimicking the intracellular colloid osmotic pressure

   • Fanny Dorine Laterveer
   • Klaas Nicolay
   • Frank Norbert Gellerich

   OriginalPaper Pages: 43 - 51

9. Small scale preparation of skeletal muscle mitochondria, criteria of integrity, and assays with reference to tissue function

   • Hans N. Rasmussen
   • Ulla F. Rasmussen

   OriginalPaper Pages: 55 - 60

10. Rapid isolation of muscle and heart mitochondria, the lability of oxidative phosphorylation and attempts to stabilize the process in vitro by taurine, carnitine and other compounds

    • Hans R. Scholte
    • Yihong Yu
    • Herman F.M. Busch

    OriginalPaper Pages: 61 - 66

11. Tetraphenylphosphonium inhibits oxidation of physiological substrates in heart mitochondria

    • Vida Mildaziene
    • Rasa Baniene
    • Aurelijus Zimkus

    OriginalPaper Pages: 67 - 70

12. High resolution respirometry of permeabilized skeletal muscle fibers in the diagnosis of neuromuscular disorders

    • Wolfgang Sperl
    • Daniela Skladal
    • Frank Norbert Gellerich

    OriginalPaper Pages: 71 - 78

13. Detection of early ischemic damage by analysis of mitochondrial function in skinned fibers

    • Laurence Kay
    • André Rossi
    • Valdur Saks

    OriginalPaper Pages: 79 - 85

14. The effects of ischemia and experimental conditions on the respiration rate of cardiac fibers

    • Adolfas Toleikis
    • Daiva Trumbeckaite
    • Arvydas Dagys

    OriginalPaper Pages: 87 - 90

15. Insulin as a probe of mitochondrial metabolism in situ

    • Samuel P. Bessman
    • Chandra Mohan

    OriginalPaper Pages: 91 - 96

16. Detection of mitochondrial defects by laser fluorimetry

    • Wolfram S. Kunz
    • Kirstin Winkler
    • Claus W. Wallesch

    OriginalPaper Pages: 97 - 100

17. Oxidative phosphorylation in myocardial mitochondria 'in situ': a calorimetric study on permeabilized cardiac muscle preparations

    • Detlef Köhnke
    • Jürgen Daut
    • Marion Schramm

    OriginalPaper Pages: 101 - 113

18. Nicotinamide adenine dinucleotides permeate through mitochondrial membranes in human Epstein-Barr virus-transformed lymphocytes

    • P. Rustin
    • D. Chretien
    • A. Munnich

    OriginalPaper Pages: 115 - 119

19. Reversibility of thiamine deficiency-induced partial necrosis and mitochondrial uncoupling by addition of thiamine to neuroblastoma cell suspensions

    • Lucien Bettendorff
    • Guy Goessens
    • Francis E. Sluse

    OriginalPaper Pages: 121 - 124

20. Dihydroorotat-ubiquinone oxidoreductase links mitochondria in the biosynthesis of pyrimidine nucleotides

    • Monika Löffler
    • Johannes Jöckel
    • Gertrud Schuster

    OriginalPaper Pages: 125 - 129

21. Regulation of respiration and energy transduction in cytochrome c oxidase isozymes by allosteric effectors

    • Bernhard Kadenbach
    • Viola Frank
    • Jörg Napiwotzki

    OriginalPaper Pages: 131 - 135

22. Thermodynamic regulation of cytochrome oxidase

    • Bernard Korzeniewski

    OriginalPaper Pages: 137 - 141

23. Metabolic control analysis and threshold effect in oxidative phosphorylation: Implications for mitochondrial pathologies

    • T. Letellier
    • F. Bédes
    • Ramuné Morkuniene

    OriginalPaper Pages: 143 - 148

24. Identification of mitochondrial deficiency using principal component analysis

    • Gilles Durrieu
    • Thierry Letellier
    • Jean-Pierre Mazat

    OriginalPaper Pages: 149 - 156

25. The mitochondrial permeability transition in toxic, hypoxic and reperfusion injury

    • John J. Lemasters
    • Anna-Liisa Nieminen
    • Brian Herman

    OriginalPaper Pages: 159 - 165

26. Cyclosporin A binding in mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury

    • A.P. Halestrap
    • C.P. Connern
    • P.M. Kerr

    OriginalPaper Pages: 167 - 172

27. Hormonal stimulation, mitochondrial Ca²⁺ accumulation, and the control of the mitochondrial permeability transition in intact hepatocytes

    • Jan B. Hoek
    • Elisabeth Walajtys-Rode
    • Xiaolan Wang

    OriginalPaper Pages: 173 - 179

28. Two modes of activation of the permeability transition pore: The role of mitochondrial cyclophilin

    • Luca Scorrano
    • Annamaria Nicolli
    • Valeria Paolo Petronilli

    OriginalPaper Pages: 181 - 184

29. Implication of mitochondria in apoptosis

    • Patrice Xavier Petit
    • Naoufal Zamzami
    • Maria Castedo

    OriginalPaper Pages: 185 - 188

30. Nitric oxide inhibition of cytochrome oxidase and mitochondrial respiration: Implications for inflammatory, neurodegenerative and ischaemic pathologies

    • Guy C. Brown

    OriginalPaper Pages: 189 - 192

31. The role of mitochondrial dysfunction and neuronal nitric oxide in animal models of neurodegenerative diseases

    • Jörg B. Schulz
    • Russell T. Matthews
    • M. Flint Beal

    OriginalPaper Pages: 193 - 197

32. Role of endogenous and exogenous antioxidants in the defence against functional damage and lipid peroxidation in rat liver mitochondria

    • Wolfgang Augustin
    • Ingrid Wiswedel
    • Olaf Reichelt

    OriginalPaper Pages: 199 - 205

33. Analysis of the mitochondrial DNA from patients with Wolfram (DIDMOAD) syndrome

    • Sabine Hofmann
    • Reimar Bezold
    • Klaus-Dieter Gerbitz

    OriginalPaper Pages: 209 - 213

34. Point mutations in the mitochondrial tRNA^Lys gene: Implications for pathogenesis and mechanism

    • Judy P. Masucci
    • Eric A. Schon
    • Michael P. King

    OriginalPaper Pages: 215 - 219

35. Detection of mitochondrial DNA deletions by a screening procedure using the Polymerase Chain Reaction

    • Thérèse Ferlin
    • Géraldine Guironnet
    • Bénédicte Mousson

    OriginalPaper Pages: 221 - 225

36. Regulation of mitochondrial transcription by mitochondrial transcription factor A

    • Julio Montoya
    • Acisclo Perez-Martos
    • Rudolf J. Wiesner

    OriginalPaper Pages: 227 - 230

37. Multiple mitochondrial tRNAM^Leu[UUR] mutations associated with infantile myopathy

    • S. Zanssen
    • M. Molnar
    • G. Buse

    OriginalPaper Pages: 231 - 236

38. Carnitine palmitoyltransferase II deficiency: Diagnosis by molecular analysis of blood

    • Petra Kaufmann
    • Salvatore DiMauro

    OriginalPaper Pages: 237 - 239

39. Defects in the mitochondrial energy metabolism outside the respiratory chain and the pyruvate dehydrogenase complex

    • Frans J.M. Trijbels
    • Wim Ruitenbeek
    • Rob C.A. Sengers

    OriginalPaper Pages: 243 - 247

40. Chemical preconditioning: A cytoprotective strategy

    • Matthias W. Riepe
    • Albert C. Ludolph

    OriginalPaper Pages: 249 - 254

41. Inhibition of complex I by neuroleptics in normal human brain cortex parallels the extrapyramidal toxicity of neuroleptics

    • Iris Maurer
    • Hans-Jürgen Möller

    OriginalPaper Pages: 255 - 259

42. Adenine nucleotide translocator in dilated cardiomyopathy: Pathophysiological alterations in expression and function

    • A. Dörner
    • K. Schulze
    • H.-P. Schultheiss

    OriginalPaper Pages: 261 - 269

43. Mitochondrial DNA mutations in multiple symmetric lipomatosis

    • Thomas Klopstock
    • Markus Naumann
    • Heinz Reichmann

    OriginalPaper Pages: 271 - 275

44. Mitochondrial abnormalities and peripheral europathy in inflammatory myopathy, especially inclusion body myositis

    • J. Michael Schröder
    • Maria Molnar

    OriginalPaper Pages: 277 - 281

45. Mitochondrial intermembrane inclusion bodies: The common denominator between human mitochondrial myopathies and creatine depletion due to impairment of cellular energetics

    • Eddie O'Gorman
    • Thomas Piendl
    • Theo Wallimann

    OriginalPaper Pages: 283 - 289

46. Metabolic interventions against complex I deficiency in MELAS syndrome

    • Kari Majamaa
    • Harri Rusanen
    • Ilmo E. Hassinen

    OriginalPaper Pages: 291 - 296

47. Clinical, morphological, biochemical, and neuroradiological features of mitochondrial encephalomyopathies. Presentation of 19 patients

    • Alfred Lindner
    • Erich Hofmann
    • Heinz Reichmann

    OriginalPaper Pages: 297 - 303

48. Reactive oxygen species, mitochondria, apoptosis and aging

    • S. Papa
    • V.P. Skulachev

    OriginalPaper Pages: 305 - 319

49. Ageing: Effects on oxidative function of skeletal muscle in vivo

    • D.J. Taylor
    • G.J. Kemp
    • G.K. Radda

    OriginalPaper Pages: 321 - 324

50. Mitochondrial involvement in the ageing process. Facts and controversies

    • Elizabeth J. Brierley
    • Margaret A. Johnson
    • Douglass M. Turnbull

    OriginalPaper Pages: 325 - 328