1. Evaluation of false positive rate based on exposure–response analyses for two compounds in fixed-dose combination products

   • Hao Zhu
   • Yaning Wang

   OriginalPaper 06 September 2011 Pages: 671 - 696

   

2. A hidden Markov model to assess drug-induced sleep fragmentation in the telemetered rat

   • C. Diack
   • O. Ackaert
   • D. Fairman

   OriginalPaper Open access 10 September 2011 Pages: 697 - 711

   

3. Mechanism-based population modelling for assessment of L-cell function based on total GLP-1 response following an oral glucose tolerance test

   • Jonas B. Møller
   • William J. Jusko
   • Steen H. Ingwersen

   OriginalPaper 16 September 2011 Pages: 713 - 725

   

4. Non-linear mixed effects modeling of antiretroviral drug response after administration of lopinavir, atazanavir and efavirenz containing regimens to treatment-naïve HIV-1 infected patients

   • Daniel Röshammar
   • Ulrika S. H. Simonsson
   • Magnus Gisslén

   OriginalPaper 02 October 2011 Pages: 727 - 742

   

5. The influence of distributional kinetics into a peripheral compartment on the pharmacokinetics of substrate partitioning between blood and brain tissue

   • Jeannie M. Padowski
   • Gary M. Pollack

   OriginalPaper 09 October 2011 Pages: 743 - 767

   

6. Population pharmacokinetic–pharmacodynamic–disease progression model for effects of anakinra in Lewis rats with collagen-induced arthritis

   • Dongyang Liu
   • Hoi-Kei Lon
   • William J. Jusko

   OriginalPaper 16 October 2011 Pages: 769 - 786

   

7. Modeling red blood cell survival data

   • Julia Korell
   • Frederiek E. Vos
   • Stephen B. Duffull

   OriginalPaper 14 October 2011 Pages: 787 - 801

   

8. Model-based determination of abatacept exposure in support of the recommended dose for Japanese rheumatoid arthritis patients

   • Mayumi Hasegawa
   • Yasuhiko Imai
   • Amit Roy

   OriginalPaper 15 October 2011 Pages: 803 - 832

   

9. Extending the latent variable model for extra correlated longitudinal dichotomous responses

   • Matthew M. Hutmacher
   • Jonathan L. French

   OriginalPaper 22 October 2011 Pages: 833 - 859

   

10. Automatic data binning for improved visual diagnosis of pharmacometric models

    • Marc Lavielle
    • Kevin Bleakley

    OriginalPaper 26 October 2011 Pages: 861 - 871

    

11. Coping with time scales in disease systems analysis: application to bone remodeling

    • Stephan Schmidt
    • Teun M. Post
    • Meindert Danhof

    OriginalPaper Open access 26 October 2011 Pages: 873 - 900