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Catecholaminergic neurons of mammalian brain and neuromelanin

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Abstract

The brain neurons synthesizing catecholamines are ones of the most studied populations of nerve cells. The most essential morphological difference of these cells in many mammalian species—the presence of pigment neuromelanin in their cytoplasm. The issue of role of neuromelanin in cell seems important for comparative neurobiology, as it not only is absent in neurons of different transmitter nature, but even in catecholaminergic neurons in some species of laboratory animals, which restricts possibilities of experimental testing of available hypotheses about its functions in norm and in pathology. For the last few years neuromelanin attracts particular interest in the researchers studying neurotoxicity and modulation of Parkinson’s disease. In the presented review there are generalized and analyzed novel data about structure and functions of neuromelanin, as well as discussed is its possible role in pathogenesis of Parkinson’s disease.

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Authors and Affiliations

  1. Research Institute of Experimental Medicine, Northwestern Branch of Russian Academy of Medical Sciences, St. Petersburg, Russia

    E. G. Sukhorukova, O. S. Alekseeva & D. E. Korzhevsky

  2. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia

    O. S. Alekseeva

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  1. E. G. Sukhorukova
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Original Russian Text © E.G. Sukhorukova, O.S. Alekseeva, D.E. Korzhevsky, 2014, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2014, Vol. 50, No. 5, pp. 336–342.

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Sukhorukova, E.G., Alekseeva, O.S. & Korzhevsky, D.E. Catecholaminergic neurons of mammalian brain and neuromelanin. J Evol Biochem Phys 50, 383–391 (2014). https://doi.org/10.1134/S0022093014050020

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