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Polysaccharide-based Nanoparticles for Gene Delivery

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Abstract

Nanoparticles based on nanotechnology and biotechnology have emerged as efficient carriers for various biopharmaceutical agents including proteins and genes. In particular, polysaccharides have attracted interest of many researchers in the drug delivery field due to their advantages such as biocompatibility, biodegradability, low toxicity, and ease of modification. A number of polysaccharides including chitosan, hyaluronic acid, and dextran, and their derivatives have been widely used as polymeric backbones for the formation of nanoparticles, which can be provided as valuable gene delivery carriers. In this review, we introduce the chemical and physical natures of different polysaccharides particularly used in biomedical applications, and then discuss recent progress in the development of polysaccharide-based nanoparticles for gene delivery.

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Acknowledgements

This study was funded by the Global Research Lab (GRL) Project (NRF-2013K1A1A2A02050115), the Global Innovative Research Center (GiRC; NRF-2012K1A1A2A01055811), and the Intramural Research Program of Korea Institute of Science and Technology (KIST).

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    Authors and Affiliations

    1. Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Hwarangno 14-gil 5, Seongbuk-gu, Seoul, 136-791, Republic of Korea

      Myung Sook Huh, Eun Jung Lee, Ji Young Yhee, Keun Sang Oh, Sohee Son, Sojin Lee, Sun Hwa Kim, Ick Chan Kwon & Kwangmeyung Kim

    2. Department of Medical Lifescience, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea

      Heebeom Koo

    3. KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea

      Ick Chan Kwon

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    2. Eun Jung Lee
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    3. Heebeom Koo
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    4. Ji Young Yhee
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    5. Keun Sang Oh
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    6. Sohee Son
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    7. Sojin Lee
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    8. Sun Hwa Kim
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    9. Ick Chan Kwon
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    10. Kwangmeyung Kim
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    Corresponding authors

    Correspondence to Ick Chan Kwon or Kwangmeyung Kim.

    Additional information

    This article is part of the Topical Collection “Polymeric Gene Delivery Systems”; edited by Yiyun Cheng.

    M. S. Huh and E. J. Lee contributed equally.

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    Huh, M.S., Lee, E.J., Koo, H. et al. Polysaccharide-based Nanoparticles for Gene Delivery. Top Curr Chem (Z) 375, 31 (2017). https://doi.org/10.1007/s41061-017-0114-y

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    • DOI: https://doi.org/10.1007/s41061-017-0114-y

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