Abstract
Chemotherapy related cognitive impairments are common in breast cancer patients undergoing chemotherapy. These cognitive dysfunctions are mainly attributable to chemotherapy related brain structural and functional alterations. Multimodality magnetic resonance imaging (MRI) can reveal brain gray matter volume loss, white matter microstructural disruption, reduced gray matter density, impaired cerebral blood flow and brain structural and functional connection networks at both local and global levels. This review outlines the potential applications of multimodality MR imaging techniques in chemotherapy induced cognitive deficit in breast cancer survivors and provides future research perspective in this field.
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Abbreviations
- MRI:
-
Magnetic resonance imaging
- BOLD:
-
Blood oxygen level dependent
- fMRI:
-
Functional MRI
- VBM:
-
Voxel-based morphological
- DTI:
-
Diffusion tensor imaging
- ASL:
-
Arterial spin labeling
- CRCI:
-
Chemotherapy related cognitive impairment
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Feng, Y., Zhang, X.D., Zheng, G. et al. Chemotherapy-induced brain changes in breast cancer survivors: evaluation with multimodality magnetic resonance imaging. Brain Imaging and Behavior 13, 1799–1814 (2019). https://doi.org/10.1007/s11682-019-00074-y
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DOI: https://doi.org/10.1007/s11682-019-00074-y