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Chemotherapy-related cognitive dysfunction: current animal studies and future directions

  • SI: Neuroimaging Studies of Cancer and Cancer Treatment
  • Published:
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Abstract

Cognitive impairment is a potential long-term side effect of adjuvant chemotherapy that can have a major impact on the quality of life of cancer survivors. There is a growing number of preclinical studies addressing this issue, thereby extending our knowledge of the mechanisms underlying chemotherapy-induced neurotoxicity. In this review, we will summarize the recent advances and important findings presented in these studies. Emerging challenges, such as the development of neuroprotective strategies, and the role of the blood-brain barrier on cognitive impairment will be described and future directions in this field of investigation will be outlined.

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Authors and Affiliations

  1. Department of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

    R. Seigers & S. B. Schagen

  2. Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

    O. Van Tellingen

  3. Department of Neurology, Division of Neuro-Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA

    J. Dietrich

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  1. R. Seigers
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  2. S. B. Schagen
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  3. O. Van Tellingen
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  4. J. Dietrich
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Correspondence to R. Seigers.

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Seigers, R., Schagen, S.B., Van Tellingen, O. et al. Chemotherapy-related cognitive dysfunction: current animal studies and future directions. Brain Imaging and Behavior 7, 453–459 (2013). https://doi.org/10.1007/s11682-013-9250-3

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