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Nanostructured base electrochemical sensor for voltammetric determination of homocysteine using a modified single-walled carbon nanotubes paste electrode

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Abstract

A carbon paste electrode modified with benzoylferrocene (BF) and carbon nanotubes (CNTs) have been applied to the electrocatalytic oxidation of homocysteine which reduced the overpotential by about 165 mV with an obvious increase in the current response. The transfer coefficient (α) for the electrocatalytic oxidation of homocysteine and diffusion coefficient of this substance under the experimental conditions were also investigated. In a phosphate buffer solution (PBS) of pH 7.0, the oxidation current increased linearly with two concentration intervals of homocysteine; one is 0.1 to 10.0 μM, and the other is 10.0 to 80.0 μM. The detection limit (3σ) obtained by square wave voltammetry (SWV) was 50.0 nM. The proposed method was successfully applied to the determination of homocysteine in real samples.

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References

  1. Lin J, Wei Z, Zhang H, Shao M (2013) Biosens Bioelectron 41:342

    Article  CAS  Google Scholar 

  2. Mohammadi S, Beitollahi H, Mohadesi A (2013) Sensor Lett 11:388

    Article  CAS  Google Scholar 

  3. Manivel A, Velayutham D, Noel M (2010) Ionics 16:153

    Article  CAS  Google Scholar 

  4. Im JS, Yun J, Kim JG, Bae TS, Lee YS (2012) Appl Surf Sci 258:2219

    Article  CAS  Google Scholar 

  5. Raoof JB, Ojani R, Beitollahi H, Hosseinzadeh R (2006) Anal Sci 22:1213

    Article  CAS  Google Scholar 

  6. Afkhami A, Bagheri H, Khoshsafar H, Saber-Tehrani M, Tabatabaee M, Shirzadmehr A (2012) Anal Chim Acta 746:98

    Article  CAS  Google Scholar 

  7. Li J, Xie H (2013) Ionics 19:105

    Article  Google Scholar 

  8. Arvand M, Kermanian M (2013) Food Anal Methods 6:578

    Article  Google Scholar 

  9. Rafiee B, Fakhari AR (2013) Biosens Bioelectron 46:130

    Article  CAS  Google Scholar 

  10. Vedhi C, Selvanathan G, Arumugam P, Manisankar P (2009) Ionics 15:377

    Article  CAS  Google Scholar 

  11. Beitollahi H, Taher MA, Ahmadipour M, Hosseinzadeh R (2014) Measurement 47:770

    Article  Google Scholar 

  12. Ahmad Dar R, Brahman PK, Tiwari S, Pitre KS (2012) Colloids Surf B 91:10

    Article  Google Scholar 

  13. Beitollahi H, Raoof JB, Hosseinzadeh R (2011) Anal Sci 27:991

    Article  CAS  Google Scholar 

  14. Kumar D, Prasad BB (2012) Sens Actuators B 171:1141

    Article  Google Scholar 

  15. Marco JP, Borges KB, Teixeira Tarley CR, Ribeiro ES, Pereira AC (2013) Sens Actuators B 177:251

    Article  CAS  Google Scholar 

  16. Wang Zh, Liu G, Zhang L, Wang H (2013) Ionics. doi:10.1007/s11581-013-0891-4

  17. Tajik S, Taher MA, Beitollahi H (2013) Sens Actuators B 188:923

    Article  CAS  Google Scholar 

  18. Zhang X, Dou W, Zhan X, Zhao G (2012) Electrochim Acta 61:73

    Article  CAS  Google Scholar 

  19. Noroozifar M, Khorasani-Motlagh M, Bemanadi Parizi M, Akbari R (2013) Ionics 19:1317

    Article  CAS  Google Scholar 

  20. Taleat Z, Mazloum Ardakani M, Naeimi H, Beitollahi H, Nejati M, Zare HR (2008) Anal Sci 24:1039

    Article  CAS  Google Scholar 

  21. Malode SJ, Shetti NP, Nandibewoor ST (2012) Colloids Surf B 97:1

    Article  CAS  Google Scholar 

  22. Sun W, Liu J, Ju X, Zhang L, Qi X, Hui H (2013) Ionics 19:657

    Article  CAS  Google Scholar 

  23. Malode SJ, Abbar JC, Shetti NP, Nandibewoor ST (2012) Electrochim Acta 60:95

    Article  CAS  Google Scholar 

  24. Mazloum-Ardakani M, Beitollahi H, Amini MK, Mirkhalaf F, Abdollahi-Alibeik M (2010) Sens Actuators B 151:243

    Article  CAS  Google Scholar 

  25. Raoof JB, Chekin F, Ojani R, Barari S (2013) J Chem Sci 125:283

    Article  CAS  Google Scholar 

  26. Babaei A, Taheri AR, Khani Farahani I (2013) Sens Actuators B 183:265

    Article  CAS  Google Scholar 

  27. Afkhami A, Madrakian T, Shirzadmehr A, Bagheri H, Tabatabaee M (2012) Ionics 18:881

    Article  CAS  Google Scholar 

  28. Samadi-Maybodi A, Hassani Nejad-Darzi SK, Ganjali MR, Ilkhani H (2013) J Solid State Electrochem 17:2043

    Article  CAS  Google Scholar 

  29. Mani V, Devadas B, Chen SM (2013) Biosens Bioelectron 41:309

    Article  CAS  Google Scholar 

  30. Agrawal SL, Rai N, Natarajan TS, Chand N (2013) Ionics 19:145

    Article  CAS  Google Scholar 

  31. Dogan-Topal B (2013) J Solid State Electrochem 17:1059

    Article  CAS  Google Scholar 

  32. Melucci D, Locatelli C (2012) J Electroanal Chem 675:25

    Article  CAS  Google Scholar 

  33. Mokhtari A, Karimi-Maleh H, Ensafi AA, Beitollahi H (2012) Sens Actuators B 169:96

    Article  CAS  Google Scholar 

  34. Li L, Liang B, Li F, Shi J, Mascini M, Lang Q, Liu A (2013) Biosens Bioelectron 42:156

    Article  CAS  Google Scholar 

  35. Luo S, Wu Y, Gou H (2013) Ionics 19:673

    Article  CAS  Google Scholar 

  36. Kumar Brahman P, Ahmad Dar R, Pitre KS (2013) Sens Actuators B 177:807

    Article  Google Scholar 

  37. Raoof JB, Ojani R, Beitollahi H (2007) Electroanalysis 19:1822

    Article  CAS  Google Scholar 

  38. Chu HY, Lai QY, Wang L, Lu JF, Zhao Y (2010) Ionics 16:233

    Article  CAS  Google Scholar 

  39. Prasad BB, Prasad A, Prasad MT (2013) Electrochim Acta 102:400

    Article  CAS  Google Scholar 

  40. Raoof JB, Ojani R, Beitollahi H, Hossienzadeh R (2006) Electroanalysis 18:1193

    Article  CAS  Google Scholar 

  41. Li J, Kuang D, Feng Y, Zhang F, Xu Z, Liu M, Wang D (2013) Microchim Acta 180:49

    Article  CAS  Google Scholar 

  42. Ensafi AA, Izadi M, Rezaei B, Karimi-Maleh H (2012) J Mol Liq 174:42

    Article  CAS  Google Scholar 

  43. Iijima S (1991) Nature 354:56

    Article  CAS  Google Scholar 

  44. Palanisamy S, Cheemalapati S, Chen SM (2012) Anal Biochem 429:108

    Article  CAS  Google Scholar 

  45. Beitollahi H, Raoof JB, Hosseinzadeh R (2011) Electroanalysis 23:1934

    Article  CAS  Google Scholar 

  46. Nekrassova O, Lawrence NS, Compton RG (2003) Talanta 60:1085

    Article  CAS  Google Scholar 

  47. Rasmussen K, Møller J (2000) Ann Clin Biochem 37:627

    Article  CAS  Google Scholar 

  48. Carmel R, Jacobsen DW (2001) Homocysteine in health and disease. Cambridge University Press, Cambridge

    Google Scholar 

  49. Nekrassova O, White PC, Threlfell S, Hignett G, Wain AJ, Lawrence NS, Davis J, Compton RG (2002) Analyst 127:797

    Article  CAS  Google Scholar 

  50. White PC, Lawrence NS, Davis J, Compton RG (2001) Anal Chim Acta 447:1

    Article  CAS  Google Scholar 

  51. Hignett G, Threlfell S, Wain AJ, Lawrence NS, Wilkins SJ, Davis J, Compton RG, Cardosi MF (2001) Analyst 126:353

    Article  CAS  Google Scholar 

  52. Nekrassova O, Lawrence NS, Compton RG (2003) Electroanalysis 15:1655

    Article  CAS  Google Scholar 

  53. Sharifi E, Salimi A, Shams E (2012) Bioelectrochemistry 86:9

    Article  CAS  Google Scholar 

  54. Kalimuthu P, John SA (2010) Bioelectrochemistry 79:168

    Article  CAS  Google Scholar 

  55. Agüí L, Peña-Farfal C, Yáñez-Sedeño P, Pingarrón JM (2007) Talanta 74:412

    Article  Google Scholar 

  56. Gong K, Dong Y, Xiong S, Chen Y, Mao L (2004) Biosens Bioelectron 20:253

    Article  CAS  Google Scholar 

  57. Lawrence NS, Deo RP, Wang J (2004) Talanta 63:443

    Article  CAS  Google Scholar 

  58. Heyrovský M, Vavřička S (1999) Bioelectrochem Bioenerg 48:43

    Article  Google Scholar 

  59. Gholami-Orimi F, Taleshi F, Biparva P, Karimi-Maleh H, Beitollahi H, Ebrahimi HR, Shamshiri M, Bagheri H, Fouladgar M, Taherkhani A (2012) J Anal Methods Chem doi:10.1155/2012/902184

  60. Inoue T, Kirchhoff JR (2002) Anal Chem 74:1349

    Article  CAS  Google Scholar 

  61. Bard AJ, Faulkner LR (2001) Electrochemical methods: fundamentals and applications, 2nd edn. Wiley, New York

    Google Scholar 

  62. Xu H, Zhang W, Zhu W, Wang D, Ye J, Yamamoto K, Jin L (2005) Anal Chim Acta 545:182

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Payame Noor University, P.O. box 19395-4697, Tehran, Iran

    Hossein Soltani & Abdol-Hamid Hatefi-Mehrjardi

  2. Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran

    Hadi Beitollahi

  3. Department of Chemistry, Shahid Bahonar University of Kerman, P.O. box 76175-133, Kerman, Iran

    Somayeh Tajik

  4. Young Researchers Society, Shahid Bahonar University of Kerman, P.O. box 76175-133, Kerman, Iran

    Somayeh Tajik

  5. Biotechnology Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran

    Masoud Torkzadeh Mahani

Authors
  1. Hossein Soltani
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  2. Hadi Beitollahi
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  3. Abdol-Hamid Hatefi-Mehrjardi
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  4. Somayeh Tajik
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  5. Masoud Torkzadeh Mahani
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Correspondence to Hossein Soltani.

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Soltani, H., Beitollahi, H., Hatefi-Mehrjardi, AH. et al. Nanostructured base electrochemical sensor for voltammetric determination of homocysteine using a modified single-walled carbon nanotubes paste electrode. Ionics 20, 1481–1488 (2014). https://doi.org/10.1007/s11581-014-1099-y

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  • DOI: https://doi.org/10.1007/s11581-014-1099-y

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