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Preoperative Antibiotic Prophylaxis Does Not Reduce the Risk of Postoperative Infectious Complications in Patients Undergoing Elective Hepatectomy

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Abstract

Background and Aim

Postoperative infection is not uncommon after hepatectomy. This study assessed the effectiveness of preoperative antibiotic prophylaxis in elective hepatectomy in a randomized clinical trial setting.

Methods

A total of 120 patients who were scheduled to undergo elective hepatectomy were equally randomized to receive either intravenous cefuroxime 1.5 g (group A) or placebo (group B) within 30 min prior to skin incision.

Results

Overall, postoperative infection occurred in 26 (21.6 %) of the 120 patients. There was no statistically significant difference between groups A and B in the incidence of overall infection (23.3 vs. 20.0 %, P = 0.658), surgical site infection (13.3 vs. 15 %, P = 0.793), and remote site infection (13.3 vs. 11.7 %, P = 0.783).

Conclusion

The use of preoperative antibiotic prophylaxis as a routine practice in patients undergoing elective hepatectomy is unnecessary because it does not reduce the risk of postoperative infectious complications.

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Acknowledgments

We thank Dr. Yanfang Zhao (Department of Health Statistics, Second Military Medical University, Shanghai, China) for her critical revision of the statistical analysis section.

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    Authors and Affiliations

    1. Department of Hepatobiliary and Pancreatovascular Surgery, First Affiliated Hospital of Xiamen University, Xiamen, China

      Yan-Ming Zhou, Zhen-Yi Chen, Xiu-Dong Li, Dong-Hui Xu, Xu Su & Bin Li

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    1. Yan-Ming Zhou
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    Correspondence to Bin Li.

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    Yan-Ming Zhou and Zhen-Yi Chen have contributed equally to this work.

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    Zhou, YM., Chen, ZY., Li, XD. et al. Preoperative Antibiotic Prophylaxis Does Not Reduce the Risk of Postoperative Infectious Complications in Patients Undergoing Elective Hepatectomy. Dig Dis Sci 61, 1707–1713 (2016). https://doi.org/10.1007/s10620-015-4008-y

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