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Applications of Multiple Reaction Monitoring to Clinical Glycomics

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Abstract

Multiple reaction monitoring or MRM is widely acknowledged for its accuracy of quantitation. The applications have mostly been in the analysis of small molecules and proteins, but its utility is expanding. Protein glycosylation was recently identified as a new paradigm in biomarker discovery for health and disease. A number of recent studies have now identified differential glycosylation patterns associated with health and disease states, including aging, pregnancy, rheumatoid arthritis, and different types of cancer. While the use of MRM in clinical glycomics is still in its infancy, it can likely play a role in the quantitation of protein glycosylation in the clinical setting. Here, we aim to review the current advances in the nascent application of MRM in the field of glycomics.

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Acknowledgments

The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Research reported in this publication was supported by the National Institute of Child Health and Human Development, National Institute of General Medicine, National Center of Complementary and Alternative Medicine of the National Institutes of Health under award number R01HD061923, R01GM049077, R01 AT007079, and 1U24DK097154.

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Author notes

  1. L. Renee Ruhaak

    Present address: Department of Translational Molecular Pathology, MD Anderson Cancer Center, 6767 Bertner Avenue, Houston, TX, 77030, USA

Authors and Affiliations

  1. Department of Chemistry, University of California Davis, One Shields Avenue, Davis, CA, 95616, USA

    L. Renee Ruhaak & Carlito B. Lebrilla

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  1. L. Renee Ruhaak
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  2. Carlito B. Lebrilla
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Correspondence to L. Renee Ruhaak.

Additional information

Published in the topical collection Recent Developments in Clinical Omics with guest editors Martin Giera and Manfred Wuhrer.

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Ruhaak, L.R., Lebrilla, C.B. Applications of Multiple Reaction Monitoring to Clinical Glycomics. Chromatographia 78, 335–342 (2015). https://doi.org/10.1007/s10337-014-2783-9

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