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An SEIQR model for childhood diseases

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Abstract

It has been shown that the inclusion of an isolated class in the classical SIR model for childhood diseases can be responsible for self-sustained oscillations. Hence, the recurrent outbreaks of such diseases can be caused by autonomous, deterministic factors. We extend the model to include a latent class (i.e. individuals who are infected with the disease, but are not yet able to pass the disease to others) and study the resulting dynamics. The existence of Hopf bifurcations is shown for the model, as well as a homoclinic bifurcation for a perturbation to the model. For historical data on scarlet fever in England, our model agrees with the epidemiological data much more closely than the model without the latent class. For other childhood diseases, our model suggests that isolation is unlikely to be a major factor in sustained oscillations.

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References

  1. Anderson RM, May RM (1982) Directly transmitted infectious diseases: control by vaccination. Science 215: 1053–1060

    Article  MathSciNet  Google Scholar 

  2. Anderson RM, May RM (1992) Infectious diseases of humans: dynamics and control. Oxford University Press, New York

    Google Scholar 

  3. Bernoulli D (1976) Essai d’une nouvelle analyse de la mortalité causée par la petite vérole. Mem Math Phy Acad Roy Sci Paris (1766). English translation entitled ‘An attempt at a new analysis of the mortality caused by smallpox and of the advantages of inoculation to prevent it’ In: Bradley L (ed) Smallpox Inoculation: An Eighteenth Century Mathematical Controversy, Adult Education Department, Nottingham, 1971, p 21

  4. Diekmann O, Heesterbeek J (2000) Mathematical epidemiology of infectious diseases: Model building, analysis and interpretation. Wiley, Chichester

    Google Scholar 

  5. Doedel E (1981) Auto: a program for the automatic bifurcation analysis of autonomous systems. Congr Numer 30: 265–284

    MathSciNet  Google Scholar 

  6. Emerson H (1937) Measles and whooping cough. Am J Public Health 27: 1–153

    Article  Google Scholar 

  7. Feng Z (1994) A mathematical model for the dynamics of childhood diseases under the impact of isolation. Ph.D. thesis, Arizona State University

  8. Feng Z, Thieme HR (1995) Recurrent outbreaks of childhood diseases revisited: the impact of isolation. Math Biosci 128: 93–130

    Article  MATH  MathSciNet  Google Scholar 

  9. Gao LQ, Mena-Lorca J, Hethcote HW (1995) Four SEI endemic models with periodicity and separatrices. Math Biosci 128: 157–184

    Article  MATH  MathSciNet  Google Scholar 

  10. Greenhalgh D (1990) Deterministic models for common childhood diseases. Int J Syst Sci 21: 1–20

    Article  MATH  MathSciNet  Google Scholar 

  11. Kato T (1984) Perturbation theory for linear operators. Springer, Berlin

    MATH  Google Scholar 

  12. London WP, Yorke JA (1973) Recurrent outbreaks of measles, chickenpox and mumps. Am J Epidemiol 98: 453–468

    Google Scholar 

  13. Perko L (1996) Differential equations and dynamical systems, 2nd edn. Springer, New York

    MATH  Google Scholar 

  14. Thieme HR (1992) Epidemic and demographic interaction in the spread of potentially fatal diseases in growing populations. Math Biosci 111: 99–130

    Article  MATH  MathSciNet  Google Scholar 

  15. Thieme HR (1993) Persistence under relaxed point-dissipativity (with applications to an endemic model). SIAM J Math Anal 24: 407–435

    Article  MATH  MathSciNet  Google Scholar 

  16. Wiggins S (2003) Introduction to applied nonlinear dynamical systems and chaos, 2nd edn. Springer, New York

    MATH  Google Scholar 

  17. Wu LI, Feng Z (2000) Homoclinic bifurcation in an SIQR model for childhood diseases. J Differ Equ 168: 150–167

    Article  MATH  MathSciNet  Google Scholar 

  18. Zhou J, Hethcote HW (1994) Population size dependent incidence in models for diseases without immunity. J Math Biol 32: 809–834

    Article  MATH  Google Scholar 

Download references

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Correspondence to David J. Gerberry.

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Gerberry, D.J., Milner, F.A. An SEIQR model for childhood diseases. J. Math. Biol. 59, 535–561 (2009). https://doi.org/10.1007/s00285-008-0239-2

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  • DOI: https://doi.org/10.1007/s00285-008-0239-2

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