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Exercise affects biological characteristics of mesenchymal stromal cells derived from bone marrow and adipose tissue

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Abstract

Both bone marrow mesenchymal stromal cells (BMSCs) and adipose-derived mesenchymal stromal cells (ADSCs) are good sources for tissue engineering. To maximize therapeutic efficacy of MSCs, an appropriate source of MSCs should be selected according to their own inherent characteristics for future clinical application. Hence, this study was conducted to compare proliferative, differential and antiapoptosis abilities of both MSCs derived from exercised and sedentary rats under normal and hypoxia/serum deprivation conditions (H/SD). Our results showed that exercise may enhance proliferative ability and decrease adipogenic ability of BMSCs and ADSCs. However, positive effect of exercise on osteogenesis was only observed for BMSCs in either environment. Little effect was observed on the antiapoptotic ability of both MSC types. It was also suggested that biological characteristics of both types were partly changed. It is therefore believed that BMSCs derived from exercised rat on early passage may be a good cell source for bone tissue engineering.

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Authors and Affiliations

  1. Department of Orthopeadics and Traumatology, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue (N), Guangzhou, 510515, China

    Sheng-Yao Liu, Yong-Bin He, Song-Yun Deng, Shao-Yong Xu & Guo-Xin Ni

  2. Biomaterial Research Center, School of pharmaceutical sciences, Southern Medical University, 1838 Guangzhou Avenue (N), Guangzhou, 510515, China

    Wen-Ting Zhu

  3. Department of Rehabilitation Medicine, First Affiliated Hospital, Fujian Medical University, 20 Chazhong Road, Fuzhou, 350005, China

    Guo-Xin Ni

Authors
  1. Sheng-Yao Liu
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  2. Yong-Bin He
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  3. Song-Yun Deng
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  4. Wen-Ting Zhu
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  5. Shao-Yong Xu
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  6. Guo-Xin Ni
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Correspondence to Guo-Xin Ni.

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Competing interests

ShengYao Liu, YongBin He, SongYun Deng, WenTing Zhu and GuoXin Ni declare that they have no conflicts of interest.

Funding

This work was supported by National Natural Science Foundation of China (81572219), Guangdong Natural Science Foundation (2014A030313307) and Fujian Natural Science Foundation (2016J01450).

Ethical approval

All procedures performed in this study were in accordance with animal ethics committee of Nanfang Hospital, Southern Medical University.

Additional information

Sheng-Yao Liu, Yong-Bin He, and Song-Yun Deng are first coauthors

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Liu, SY., He, YB., Deng, SY. et al. Exercise affects biological characteristics of mesenchymal stromal cells derived from bone marrow and adipose tissue. International Orthopaedics (SICOT) 41, 1199–1209 (2017). https://doi.org/10.1007/s00264-017-3441-2

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  • DOI: https://doi.org/10.1007/s00264-017-3441-2

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