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Restrictive pulmonary dysfunction is associated with vertebral fractures and bone loss in elderly postmenopausal women

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Abstract

Summary

Association between lung function and bone metabolism remains controversial. We found that impaired lung function was associated with vertebral fractures and bone loss in Japanese postmenopausal women. While vertebral deformities would impair lung function, respiratory dysfunction might in turn increase fracture risk, suggesting a complex bidirectional interaction.

Introduction

Association between bone metabolism and pulmonary function in the general population is controversial. The aim of this study was to investigate relationship between lung and bone parameters in elderly postmenopausal women.

Methods

One hundred and six postmenopausal women (75.6 ± 8.0 years old) who underwent spirometric tests were examined for prevalent vertebral fractures, bone mineral density (BMD), bone metabolic markers, and other metabolic indices such as urinary pentosidine.

Results

Multivariable logistic regression analyses revealed that forced vital capacity (FVC) (OR = 0.063, 95% CI: 0.011–0.352, p = 0.002) and urinary pentosidine (OR = 1.067, 95% CI: 1.020–1.117, p = 0.005) were associated with the presence of vertebral fractures after adjustment for height loss, age, and BMD at femoral neck. Moreover, vital capacity (VC) or FVC as well as body mass index and age was among independent determinants of BMD after adjustment for height loss and the number and grade of vertebral fractures in forced multiple linear regression analysis (VC: β = 0.212, p = 0.021, FVC: β = 0.217, p = 0.031). Urinary pentosidine was negatively correlated with pulmonary function parameters such as FVC and forced expiratory volume in 1 s (FEV1.0), although these correlations appeared dependent on age.

Conclusions

Diminished FVC was associated with prevalent vertebral fractures and decreased BMD in Japanese postmenopausal women without apparent pulmonary diseases. Mechanism of such association between pulmonary function and bone status remains to be determined.

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Acknowledgments

We would like to thank Yoshie Fujita and Kanako Yamagishi (measurement of respiratory function) for their technical assistance.

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Authors and Affiliations

  1. Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, Ichihara-shi, Chiba, 299-0111, Japan

    R. Watanabe, R. Okazaki & D. Inoue

  2. Research Institute and Practice for Involutional Diseases, 1610-1 Meisei, Misato, Azumino, Nagano, 399-8101, Japan

    M. Shiraki

  3. Department of Orthopaedic Surgery, Jikei University School of Medicine, 3-19-18 Nishishinbashi, Minato-ku, Tokyo, 105-1471, Japan

    M. Saito

Authors
  1. R. Watanabe
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  2. M. Shiraki
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  4. R. Okazaki
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  5. D. Inoue
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Corresponding author

Correspondence to D. Inoue.

Ethics declarations

The protocol was approved by the Ethics Committee at the Research Institute and Practice for Involutional Diseases, and we obtained comprehensive written informed consent from all subjects.

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Watanabe, R., Shiraki, M., Saito, M. et al. Restrictive pulmonary dysfunction is associated with vertebral fractures and bone loss in elderly postmenopausal women. Osteoporos Int 29, 625–633 (2018). https://doi.org/10.1007/s00198-017-4337-0

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  • DOI: https://doi.org/10.1007/s00198-017-4337-0

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