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Chronic obstructive pulmonary disease (COPD) patients with osteoporotic vertebral compression fractures (OVCFs): improvement of pulmonary function after percutaneous vertebroplasty (VTP)

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  • Published:
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Abstract

Objectives

To investigate the changes of respiratory function in patients affected by chronic obstructive pulmonary disease (COPD) with single dorsal osteoporotic vertebral compression fractures (OVCFs) treated with vertebroplasty (VTP).

Methods

Forty-five patients affected by COPD and single dorsal OVCF underwent VTP (29 men, 16 women; mean age 71.4 years, range 65–77 years). Inclusion criteria were magnetic resonance findings of bone marrow oedema, without intracanal bone fragments and refractory pain to medical treatment for at least 3 months. Osteoporosis was assessed by bone densitometry. Spirometry was performed before and after treatment.

Results

A significant VAS-score decrease was observed 1 week after VTP, with a subsequent decrease over time; vital capacity (VC) and forced vital capacity (FVC) improved over time, reaching a plateau at 3 months. Forced expiratory volume at 1 s (FEV1) did not significantly differ between the pre-VTP values and follow-up values. A significant correlation was observed between VAS-score values and VC, and VAS-score values and FVC. No significant correlation was observed between VAS-score values and FEV1 values.

Conclusions

VTP improves restrictive ventilatory impairment in patients with moderate and severe COPD affected by single thoracic OVCFs. We recommend this treatment in the management of these patients.

Key Points

• Osteoporosis is a major comorbidity in chronic obstructive pulmonary disease (COPD) patients.

• Pain due to osteoporotic vertebral compression fractures worsens respiratory failure in COPD.

• Vertebroplasty improves ventilatory impairment in COPD patients with osteoporotic vertebral compression fractures.

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Abbreviations

COPD:

Chronic obstructive pulmonary disease

OVCFs:

Osteoporotic vertebral compression fractures

VTP:

Vertebroplasty

PMMA:

Polymethylmethacrylate

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Acknowledgements

The scientific guarantor of this publication is Professor Salvatore Masala M.D. The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. The authors state that this work has not received any funding. No complex statistical methods were necessary for this paper. Institutional Review Board approval was not required because this study did not require off-label use of materials, methods and procedures non-standardised. Written informed consent was obtained from all subjects (patients) in this study. Methodology: prospective, observational, performed at one institution.

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Authors and Affiliations

  1. Department of Diagnostic and Molecular Imaging, Interventional Radiology and Radiation Therapy, Fondazione Policlinico “Tor Vergata”, Viale Oxford 81, 00133, Rome, Italy

    Salvatore Masala, Amedeo Taglieri, Giovanni Nano, Antonio Chiaravalloti, Eros Calabria, Roberta Di Trapano & Giovanni Simonetti

  2. Department of Biomedicine and Prevention, Faculty of Medicine, University of Rome “Tor Vergata”, Via Montpellier 1, 00133, Rome, Italy

    Andrea Magrini & Antonio Pietroiusti

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  1. Salvatore Masala
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  2. Andrea Magrini
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  4. Giovanni Nano
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Correspondence to Amedeo Taglieri.

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Masala, S., Magrini, A., Taglieri, A. et al. Chronic obstructive pulmonary disease (COPD) patients with osteoporotic vertebral compression fractures (OVCFs): improvement of pulmonary function after percutaneous vertebroplasty (VTP). Eur Radiol 24, 1577–1585 (2014). https://doi.org/10.1007/s00330-014-3165-2

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  • DOI: https://doi.org/10.1007/s00330-014-3165-2

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