Abstract
Summary
Height loss and vertebral deformity had independent effects on health-related quality of life evaluated by the European quality-of-life five-domain questionnaire (EQ-5D) in a cohort of 2,021 elderly Japanese men and women. Height loss aggravated EQ-5D more strongly than vertebral deformity in all domains, with different patterns.
Introduction
Vertebral deformity reduces the activities of daily living and quality of life, and elevates mortality. Height loss is taken to be a sign of vertebral deformity, although other factors could also cause height loss. In this study, we examined the difference in EQ-5D between elderly with height loss and with vertebral deformity.
Methods
The subjects were 2,021 men and women aged 57–101 years from the Hiroshima Cohort who underwent health examinations in 2002–03 and responded to the EQ-5D. Vertebral deformity was assessed semi-quantitative methods using lateral chest and spine radiographs. Height was measured during the routine biennial examinations, which have been conducted since 1958. We used linear regression analyses, ordered polytomous logistic regression analyses, and Bonferroni tests.
Results
Eighty three men and 314 women had prevalent vertebral deformity. The mean height loss was 2.2 cm for men and 3.9 cm for women. Height loss ≥4 cm (P < 0.01) and vertebral deformity (P = 0.04) were independent risk factors for low EQ-5D scores, after adjustment for sex and age.
Conclusions
The present study showed that height loss and vertebral deformity affected EQ-5D significantly and independently in the elderly.
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Acknowledgements
We thank Dr. Kumiko Naito, Department of Radiology, Hiroshima University School of Medicine, for her diagnoses of diseases. We also thank Dr. Dino Samartzis, Division of Biomechanics, Department of Orthopaedic Surgery, Rush-Presbyterian-St. Luke’s Medical Center, Rush Medical College, Chicago, Illinois, USA, for his comments, suggestions, and editorial assistance. The Radiation Effects Research Foundation (RERF), Hiroshima and Nagasaki, Japan is a private, non-profit foundation funded by the Japanese Ministry of Health, Labour and Welfare and the U.S. Department of Energy, the latter through the National Academy of Sciences. This publication was supported by RERF Research Protocol RP #3-89. This study was also supported by the research of “Effects of vertebral deformity and body height loss on activity of daily living and it’s prevention among the elderly (16100201) by the Japanese Ministry of Health, Labour and Welfare”.
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Masunari, N., Fujiwara, S., Nakata, Y. et al. Historical height loss, vertebral deformity, and health-related quality of life in Hiroshima cohort study. Osteoporos Int 18, 1493–1499 (2007). https://doi.org/10.1007/s00198-007-0392-2
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DOI: https://doi.org/10.1007/s00198-007-0392-2