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Blood-brain barrier interfaces and brain tumors

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Abstract

In the developing brain, capillaries are differentiated and matured into the blood-brain barrier (BBB), which is composed of cerebral endothelial cells, astrocyte end-feet, and pericytes. Since the BBB regulates the homeostasis of central nervous system (CNS), the maintenance of the BBB is important for CNS function. The disruption of the BBB may result in many brain disorders including brain tumors. However, the molecular mechanism of BBB formation and maintenance is poorly understood. Here, we summarize recent advances in the role of oxygen tension and growth factors on BBB development and maintenance, and in BBB dysfunction related with brain tumors.

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Authors and Affiliations

  1. Neurovascular Coordination Research Center, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, 151-742, Seoul, Korea

    Sae-Won Lee, Woo Jean Kim, Jeong Ae Park, Yoon Kyung Choi & Kyu-Won Kim

  2. Stroke and neurovascular regulation laboratory, Massachusetts General Hospital, Harvard Medical School, 02129, Charlestown, MA, U.S.A.

    Sae-Won Lee

  3. Neuroprotection research laboratory, Massachusetts General Hospital, Harvard Medical School, 02129, Charlestown, MA, U.S.A.

    Woo Jean Kim

  4. Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, 20852, Rockville, Maryland, U.S.A.

    Yoo-Wook Kwon

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  1. Sae-Won Lee
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  2. Woo Jean Kim
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  3. Jeong Ae Park
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  4. Yoon Kyung Choi
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Correspondence to Kyu-Won Kim.

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Lee, SW., Kim, W.J., Park, J.A. et al. Blood-brain barrier interfaces and brain tumors. Arch Pharm Res 29, 265–275 (2006). https://doi.org/10.1007/BF02968569

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