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Role of Cerebral Endothelial Tight Junctions in the Formation of Brain Tumors

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Tight Junctions

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Abstract

Malignant brain tumors are devastating conditions, characterized by limited survival of the patients. In order to widen the therapeutic possibilities targeting cerebral malignancies, we have to understand the mechanisms of their development. In this chapter, we review the involvement of tight junctions (TJs) of cerebral endothelial cells in the formation of brain cancers. Two main aspects will be discussed. First, we cover the mechanisms of opening of the TJs of the blood-brain barrier (BBB) during paracellular extravasation of metastatic cells. In this process, proteolytic mechanisms, induction of endothelial-mesenchymal transition, release of extracellular vesicles, and modulation of cells of the neurovascular unit take the most important roles. Second, we introduce the blood-tumor barrier (BTB), that is, the altered vasculature of both primary and secondary brain tumors. Although leakier in general than the intact BBB, the BTB restricts the majority of drugs to reach cytotoxic concentrations in brain tumors.

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Authors and Affiliations

  1. Institute of Biophysics, Biological Research Centre, Eötvös Loránd Research Network (ELKH), Szeged, Hungary

    Imola Wilhelm, Kinga Molnár & István A. Krizbai

  2. Institute of Life Sciences, Vasile Goldiş Western University of Arad, Arad, Romania

    Imola Wilhelm & István A. Krizbai

Authors
  1. Imola Wilhelm
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  2. Kinga Molnár
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  3. István A. Krizbai
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Correspondence to Imola Wilhelm .

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Editors and Affiliations

  1. Department of Physiology, Biophysics, and Neuroscience, Center for Research and Advance Studies (Cinvestav), Mexico City, Mexico

    Lorenza González-Mariscal

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Wilhelm, I., Molnár, K., Krizbai, I.A. (2022). Role of Cerebral Endothelial Tight Junctions in the Formation of Brain Tumors. In: González-Mariscal, L. (eds) Tight Junctions. Springer, Cham. https://doi.org/10.1007/978-3-030-97204-2_12

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