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Proteases of Parasitic Helminths: Their Metabolic Role in Establishment of Infection in the Host

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Proteases in Human Diseases

Abstract

Proteases catalyze hydrolysis of peptide bonds in proteins and play an important role in the survival of living organisms, encoded by about 2% of the whole genome in all kind of organisms. Mostly they are nonspecific, while some are highly specific toward a peptide bond. Generally, proteases are grouped into different clan, family, and type, depending on kinds of reaction they catalyze, mechanism of catalysis, and their molecular structure and homology. Proteases control many biological processes in living organisms including helminths. There are about 1828 sequences that pertain to 25 genera of helminth parasites. In this chapter, we have discussed various types of proteases found in helminth parasites, like aspartic-, cysteine-, metallo-, and serine proteases, and their possible role in these parasites and their hosts.

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Acknowledgements

Authors thank all the workers in the field of protease research in helminths. We also apology to the authors if some of their works were not accommodated in this compilation.

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Authors and Affiliations

  1. NASI Senior Scientist Platinum Jubilee Fellow, Biotech Park, Janki Puram Sector G, Kursi Road, Lucknow, 226021, India

    Veena Tandon

  2. Department of Zoology, North-Eastern Hill University, Shillong, 793022, India

    Bidyadhar Das

  3. Department of Biochemistry, Bioinformatics Centre (Indian Council of Medical Research), Pandit Jawaharlal Nehru Memorial Medical College, Raipur, 492001, Chhattisgarh, India

    Shakti Kumar

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  1. Veena Tandon
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  2. Bidyadhar Das
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  3. Shakti Kumar
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Correspondence to Bidyadhar Das .

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Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Tapati Chakraborti

  3. Department of Physiology, Faculty of Medicine, St. Boniface General Hospital, Institute of Cardiovascular Sciences, University of Manitoba, Winnipeg, Manitoba, Canada

    Naranjan S. Dhalla

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Tandon, V., Das, B., Kumar, S. (2017). Proteases of Parasitic Helminths: Their Metabolic Role in Establishment of Infection in the Host. In: Chakraborti, S., Chakraborti, T., Dhalla, N. (eds) Proteases in Human Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-10-3162-5_12

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