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Review of Radiation Therapy for Palmar and Plantar Fibromatosis (Dupuytren and Ledderhose Disease)

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Dupuytren Disease and Related Diseases - The Cutting Edge

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Abstract

Palmar fibromatosis and plantar fibromatosis, called Dupuytren disease and Ledderhose disease (DD, LD), respectively, are chronic inflammatory and hyperproliferative connective tissue disorders which involve the palmar fascia of the hand and the plantar fascia of the foot, where they produce nodules, cords, and contractures; in addition, the overlaying subcutaneous fat and skin layers can be affected. These digitopalmar and digitoplantar alterations are part of a deforming and progressive, irreversible condition and part of a systemic connective tissue disorder (Enzinger and Weiss 1995), which is characterized by typical biochemical changes and additional fibrous deposits located at the dorsal PIP joint (forming knuckle pads), on the ear helix, the hand wrist, the elbow, and the penis forming a penile angulation (Peyronie disease). Although the tissue changes appear to have some pathohistological similarities, many studies and research efforts to identify a single cause of this generalized disorder have failed so far (Tomasek et al. 1999; Rudolph and Vande Berg 1991). Although numerous hypotheses exist about the disease onset and progression, the specific role of mesenchymal stem cells, fibroblasts, and myofibroblasts and the correlation with the clinical development of DD and LD are still not conclusively answered (Rödel and Seegenschmiedt 2016).

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References

  • Adamietz B, Keilholz L, Grünert J, Sauer R (2001) Radiotherapy of early stage Dupuytren disease. Long-term results after a median follow-up period of 10 years. Strahlenther Onkol 177(11):604–610

    Article  CAS  PubMed  Google Scholar 

  • Betz N, Ott OJ, Adamietz B, Sauer R, Fietkau R, Keilholz L (2010) Radiotherapy in early-stage Dupuytren’s contracture. Long-term results after 13 years. Strahlenther Onkol 186(2):82–90

    Article  PubMed  Google Scholar 

  • Crocker I (1999) Radiation therapy to prevent coronary artery restenosis. Sem Rad Oncol 9:134–143

    Article  CAS  Google Scholar 

  • de Bree E, Zoetmulder FA, Keus RB, Peterse HL, van Coevorden F (2004) Incidence and treatment of recurrent plantar fibromatosis by surgery and postoperative radiotherapy. Am J Surg 187(1):33–38

    Google Scholar 

  • Donato RR, Morrison WA (1996) Dupuytren’s disease in the feet causing flexion contractures in the toes. J Hand Surg Br 21(3):364–366

    Article  CAS  PubMed  Google Scholar 

  • Eng TY, Boersma MK, Fuller CD et al (2006) The role of radiation therapy in benign diseases. Hematol Oncol Clin North Am 20(2):523–557

    Article  PubMed  Google Scholar 

  • Enzinger FM, Weiss SW (1995) Soft tissue tumors, 3rd edn. CRC Press, St. Louis

    Google Scholar 

  • Falter E, Herndl E, Mühlbauer W (1991) Dupuytren’s contracture. When operate? Conservative preliminary treatment. Fortschr Med 109(10):223–226

    CAS  PubMed  Google Scholar 

  • Finney R (1955) Dupuytren’s contracture. Br J Radiol 28(335):610–614, PMID:13269766

    Article  CAS  PubMed  Google Scholar 

  • Grenfell S, Borg M (2014) Radiotherapy in fascial fibromatosis: a case series, literature review and considerations for treatment of early-stage disease. J Med Imaging Radiat Oncol 58(5):641–647

    Article  PubMed  Google Scholar 

  • Herbst M, Regler G (1985) Dupuytrensche Kontraktur. Radiotherapie der Frühstadien. Strahlentherapie 161:143–147. PMID: 3975949

    Google Scholar 

  • Hesselkamp J, Schulmeyer M, Wiskemann A (1981) Röntgentherapie der Dupuytren der Dupuytrenschen Kontraktur im Stadium I. Therapiewoche 31: 6337–6338

    Google Scholar 

  • Heyd R, Dorn AP, Herkströter M et al (2010) Radiation therapy for early stages of morbus ledderhose. Strahlenther Onkol 186(1):24–29

    Article  PubMed  Google Scholar 

  • Jansen JT, Broerse JJ, Zoetelief J et al (2005) Estimation of the carcinogenic risk of radiotherapy of benign diseases from shoulder to heel. Radiother Oncol 76(3):270–277

    Article  PubMed  Google Scholar 

  • Kal HB, Veen RE (2005) Biologically effective doses of postoperative radiotherapy in the prevention of keloids. Dose-effect relationship. Strahlenther Onkol 181(11):717–723

    Article  PubMed  Google Scholar 

  • Keilholz L, Seegenschmiedt MH, Sauer R (1996) Radiotherapy for prevention of disease progression in early-stage Dupuytren’s contracture: initial and long-term results. Int J Radiat Oncol Biol Phys 36(4):891–897

    Article  CAS  PubMed  Google Scholar 

  • Keilholz L, Seegenschmiedt MH, Born AD, Sauer R (1997) Radiotherapy in the early stage of Dupuytren’s disease. The indications, technique and long-term results. Strahlenther Onkol 173(1):27–35

    Article  CAS  PubMed  Google Scholar 

  • Ketchum LD, Donahue TK (2000) The injection of nodules of Dupuytren’s disease with triamcinolone acetonide. J Hand Surg 25:1157–1162

    Article  CAS  Google Scholar 

  • Köhler AH (1984) [Radiotherapy of Dupuytren’s contracture] German, Radiobiol Radiother (Berl) 25(6):851–853. PMID: 6528027

    Google Scholar 

  • Kutzner J, Schneider L, Seegenschmiedt MH (2003) Radiotherapy of keloids. Patterns of care study -- results. Strahlenther Onkol 179(1):54–58

    Article  PubMed  Google Scholar 

  • Leer JW, van Houtte P, Seegenschmiedt H (2007) Radiotherapy of non-malignant disorders: where do we stand? Radiother Oncol 83(2):175–177

    Article  PubMed  Google Scholar 

  • Loos B, Puschkin V, Horch RE (2007) 50 years experience with Dupuytren’s contracture in the Erlangen University Hospital--a retrospective analysis of 2919 operated hands from 1956 to 2006. BMC Musculoskelet Disord 8:60

    Article  PubMed  PubMed Central  Google Scholar 

  • Lukacs S, Braun-Falco O, Goldschmidt H (1978) Radiotherapy of benign dermatoses: indications, practice, and results. J Dermatol Surg Oncol 4(8):620–625. PMID: 151104

    Google Scholar 

  • Mafi R, Hindocha S, Khan W (2012) Recent Surgical and Medical Advances in the Treatment of Dupuytren’s Disease - A Systematic Review of the Literature. Open Orthop J 6:77–82

    Article  Google Scholar 

  • McFarlane RM, McGrouther DA, Flint MH (1990) Dupuytren’s disease. Biology and treatment, The hand and upper limb series 5. Churchill Livingstone, Edinburgh

    Google Scholar 

  • Millesi H (1981) Dupuytren-Kontraktur. In: Nigst H, Buck-Gramcko D, Millesi H (eds) Handchirurgie, Band I. Thieme, Stuttgart/New York, pp 1500–1557

    Google Scholar 

  • Murrell GAC, Francis MJO (1994) Oxygen free radicals and Dupuytren’s disease. In: Berger A, Delbrück A, Brenner P, Hinzmann R (eds) Dupuytren’s disease. Springer, Berlin/Heidelberg, pp 227–234

    Chapter  Google Scholar 

  • Murrell GAC, Francis MJO, Bromley L (1990) Modulation of fibroblast proliferation by oxygen free radicals. Biochem J 165:659–665

    Article  Google Scholar 

  • Rayan GM, Parizi M, Tomasek JJ (1996) Pharmacological regulation of Dupuytren’s fibroblast contraction in vitro. J Hand Surg Am 21:1065–1070

    Article  CAS  PubMed  Google Scholar 

  • Rödel F, Seegenschmiedt MH (2016) Introduction to radiation biology when treating hyperproliferative benign diseases. In: Werker PMN, Dias J, Eaton C, Reichert B, Wach W (eds) Dupuytren Disease and Related Diseases – The Cutting Edge. Springer International Publishing Switzerland, Cham, pp 333–339

    Google Scholar 

  • Rodemann HP, Bamberg M (1995) Cellular basis of radiation induced fibrosis. Radiother Oncol 35:83–90

    Article  CAS  PubMed  Google Scholar 

  • Rodemann HP, Peterson HP, Schwenke K, von Wangenheim KH (1991) Terminal differentiation of human fibroblasts is induced by radiation. Scanning Microsc 5(4):1135–1142, discuss 1142–3

    CAS  PubMed  Google Scholar 

  • Rubin P, Soni A, Williams JP (1999) The molecular and cellular biologic basis for radiation treatment of benign proliferative diseases. Sem Rad Oncol 9:203–214

    Article  CAS  Google Scholar 

  • Rudolph R, Vande Berg J (1991) The Myofibroblast in Dupuytren’s contracture. Hand Clin 7(4):683–692

    CAS  PubMed  Google Scholar 

  • Sammarco GJ (2001) Osteotomy of the foot and ankle. Foot Ankle Clin 6(3):xi–xiii

    Article  CAS  PubMed  Google Scholar 

  • Schuster J, Saraiya S, Tennyson N et al (2015) Patient-reported outcomes after electron radiation treatment for early-stage palmar and plantar fibromatosis. Pract Radiat Oncol 5(6):e651–e658

    Article  PubMed  Google Scholar 

  • Seegenschmiedt MH, Attassi M (2003) Radiation therapy for Morbus Ledderhose -- indication and clinical results. Strahlenther Onkol 179(12):847–853, German

    Article  PubMed  Google Scholar 

  • Seegenschmiedt MH, Micke O (2012) Radiotherapy of non-malignant diseases. Past, present and future. Strahlenther Onkol 188(Suppl 3):272–290

    Article  PubMed  Google Scholar 

  • Seegenschmiedt MH, Olschewski T, Guntrum F (2001) Radiotherapy optimization in early-stage Dupuytren’s contracture: first results of a randomized clinical study. Int J Radiat Oncol Biol Phys 49(3):785–798

    Article  CAS  PubMed  Google Scholar 

  • Seegenschmiedt MH, Micke O, Willich N (2004) Radiation therapy for nonmalignant diseases in Germany. Current concepts and future perspectives. Strahlenther Onkol 180(11):718–730

    Article  PubMed  Google Scholar 

  • Seegenschmiedt MH, Keilholz L, Wielpütz M et al (2012a) Long-Term outcome of radiotherapy for early stage Dupuytren’s disease: a phase III clinical study. In: Eaton C, Seegenschmiedt MH, Bayat A, Gabbiani G, Werker P, Wach W (eds) Dupuytren’s disease and related hyperproliferative disorders – principles, research, and clinical perspectives. Springer Publishers, Heidelberg/New York, pp 349–371

    Chapter  Google Scholar 

  • Seegenschmiedt MH, Wielpütz M, Hanslian E, Fehlauer F (2012b) Long-Term outcome of radiotherapy for early stage Dupuytren’s disease: a phase III clinical study. In: Eaton C, Seegenschmiedt MH, Bayat A, Gabbiani G, Werker P, Wach W (eds) Dupuytren’s disease and related hyperproliferative disorders – principles, research, and clinical perspectives. Springer Publishers, Heidelberg/New York, pp 409–427

    Chapter  Google Scholar 

  • Seegenschmiedt MH, Micke O, Muecke R, German Cooperative Group on Radiotherapy for Non-malignant Diseases (GCG-BD) (2015) Radiotherapy for non-malignant disorders: state of the art and update of the evidence-based practice guidelines. Br J Radiol 88(1051):20150080

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Smitt MC, Donaldson SS (1999) Radiation therapy for benign disease of the orbit. Sem Rad Oncol 9:179–189

    Article  CAS  Google Scholar 

  • Strickland JW, Idler RS, Creighton JC (1990) Dupuytren’s disease. Indiana Med 83(6):408–409

    CAS  PubMed  Google Scholar 

  • Suit H, Spiro I (1999) Radiation treatment of benign mesenchymal disease. Sem Rad Oncol 9:171–178

    Article  CAS  Google Scholar 

  • Terek RM, Jiranek WA, Goldberg MJ et al (1995) The expression of platelet-derived growth-factor gene in Dupuytren contracture. J Bone Joint Surg 77A:1–9

    Google Scholar 

  • Tomasek J, Rayan GM (1995) Correlation of alpha-smooth muscle actin expression and contraction in Dupuytren’s disease fibroblasts. J Hand Surg Am 20:450–455

    Article  CAS  PubMed  Google Scholar 

  • Tomasek JJ, Schultz RJ, Haaksma CJ (1987) Extracellular matrix-cytoskeletal connections at the surface of the specialized contractile fibroblast (myofibroblast) in Dupuytren disease. J Bone Joint Surg 68(A):1400–1407

    Google Scholar 

  • Tomasek JJ, Vaughan MB, Haaksma CJ (1999) Cellular structure and biology of Dupuytren’s disease. Hand Clin 15(1):21–33, 02

    CAS  PubMed  Google Scholar 

  • Tripuraneni P, Giap H, Jani S (1999) Endovascular brachytherapy for peripheral vascular disease. Sem Rad Oncol 199(9):190–202

    Article  Google Scholar 

  • Trott KR, Kamprad F (2006) Estimation of cancer risks from radiotherapy of benign diseases. Strahlenther Onkol 182(8):431–436

    Article  PubMed  Google Scholar 

  • Tubiana R, Michon J, Thomine JM (1966) Evaluation chiffree des deformations dans la maladie de Dupuytren. In: Maladie du Dupuytren (monographies du G.E.M.). Expansion Scientifique Francaise, Paris

    Google Scholar 

  • van der Veer WM, Hamburg SM, de Gast A, Niessen FB (2008) Recurrence of plantar fibromatosis after plantar fasciectomy: single-center long-term results. Plast Reconstr Surg 122(2):486–491

    Article  PubMed  Google Scholar 

  • Vogt HJ, Hochschau L (1980) [The treatment of Dupuytren’s contracture. A social medical problem] German, MMW Munch Med Wochenschr. 122(4):125–130. PMID: 6767935

    Google Scholar 

  • Warwick D (2015) “Dupuytren’s disease FESSH instructional course 2015”. C.G. Edizioni Medico Scientifiche, Torino

    Google Scholar 

  • Wasserburger K (1956) [Therapy of Dupuytren’s contracture]. Strahlentherapie 100(4):546–560. German. PMID: 13360519

    Google Scholar 

  • Weinzierl G, Flügel M, Geldmacher J (1993) Lack of effectiveness of alternative non-surgical treatment procedures of Dupuytren contracture. Chirurg 64(6):492–494

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Strahlenzentrum Hamburg/Cyberknife Center Hamburg, Langenhorner Chaussee 369, 22419, Hamburg, Germany

    M. Heinrich Seegenschmiedt, Karin Piefel & Thomas Schneider

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  1. M. Heinrich Seegenschmiedt
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  2. Karin Piefel
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  3. Thomas Schneider
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Correspondence to M. Heinrich Seegenschmiedt .

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Editors and Affiliations

  1. University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands

    Paul M. N. Werker

  2. Leicester General Hospital, University Hospitals of Leicester, Leicester, United Kingdom

    Joseph Dias

  3. Dupuytren Foundation, West Palm Beach, Florida, USA

    Charles Eaton

  4. Nürnberg Clinics, Paracelsus Medical University, Nürnberg, Germany

    Bert Reichert

  5. International Dupuytren Society, Übersee, Germany

    Wolfgang Wach

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Seegenschmiedt, M.H., Piefel, K., Schneider, T. (2017). Review of Radiation Therapy for Palmar and Plantar Fibromatosis (Dupuytren and Ledderhose Disease). In: Werker, P., Dias, J., Eaton, C., Reichert, B., Wach, W. (eds) Dupuytren Disease and Related Diseases - The Cutting Edge. Springer, Cham. https://doi.org/10.1007/978-3-319-32199-8_46

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  • DOI: https://doi.org/10.1007/978-3-319-32199-8_46

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