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Mori Folium regulates DSS-induced ulcerative colitis in mice and cytokine production in mast cells

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Abstract

Inflammatory bowel disease (IBD) is characterized by detrimental immune reactivity in the gut, and the imbalance between proinflammatory and anti-inflammatory reactivity. The incidence and prevalence rates of IBD in Korea have been increasing rapidly during the past decades. In this study, we investigated regulatory effect of leaf of a mulberry tree (Moraceae) called Gwasang-No.2 in Korea. Leaf of Gwasang-No.2 (Gwa.L) inhibited the inflammatory responses on dextran sulfate sodium induced ulcerative colitis in mice and the production of nitrite oxide from lipopolysaccharide and interferon-gamma stimulated mouse peritoneal macrophages. Gwa.L inhibited IL-6 and IL-8 production from HMC-1 cells without cytotoxic effects on cell viability. These results may be relevant for future pharmacological or dietary interventions in patients with ulcerative colitis.

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Authors and Affiliations

  1. Department of Oriental Pharmacy, College of Pharmacy and Wonkwang Oriental Medicines Research Institute, Wonkwang University, Iksan, Jeonbuk, 570-749, Republic of Korea

    In-Young Choi, You-Jeong Kim, Ji-Ye Kee, Min-Chol Kim, Dong-Jin Lee, Sung-One Cho, Jang-Ho Ko, Dae-Seung Kim, Yong-Deok Jeon, Cheol-Hee Yoon & Seung-Heon Hong

  2. Division of Horticulture and Pet Animal-Plant Science, Wonkwang University, Shinyong-dong, Iksan, Republic of Korea

    Yun-Jum Park

  3. College of Oriental Medicine, Kyung Hee University, Hoegi-Dong, Seoul, Republic of Korea

    Jae-Young Um

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  1. In-Young Choi
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  2. You-Jeong Kim
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  3. Ji-Ye Kee
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  4. Min-Chol Kim
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  5. Dong-Jin Lee
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  6. Sung-One Cho
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  7. Jang-Ho Ko
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  8. Dae-Seung Kim
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  9. Yong-Deok Jeon
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  10. Cheol-Hee Yoon
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  11. Yun-Jum Park
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  12. Jae-Young Um
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  13. Seung-Heon Hong
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Corresponding author

Correspondence to Seung-Heon Hong.

Additional information

In-Young Choi and You-Jeong Kim have equally contributed to this manuscript.

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Choi, IY., Kim, YJ., Kee, JY. et al. Mori Folium regulates DSS-induced ulcerative colitis in mice and cytokine production in mast cells. Orient Pharm Exp Med 12, 107–111 (2012). https://doi.org/10.1007/s13596-012-0055-5

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  • DOI: https://doi.org/10.1007/s13596-012-0055-5

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