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Case report: a successful pregnancy outcome in a patient with non-mosaic Turner syndrome (45, X) via in vitro fertilization

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Abstract

We describe a successful pregnancy outcome in a patient with non-mosaic Turner syndrome (45, X) via in vitro fertilization. The patient achieved a second pregnancy at 35 years of age. The her blood lymphocyte karyotype was examined by G-band and FISH. Furthermore, cumulus cells and her elbow skin cells were evaluated via FISH. Non-mosaic Turner syndrome was determined by G-banding [100 % (50/50) 45, X]. Lymphocytes were shown as 478/500 (95.6 %) cells of X sex chromosome signal, 15/500 (3.0 %) cells of XXX signal, and 7/500 (1.4 %) cells of XX signal. The cumulus cells were mosaic: 152/260 (58.5 %) were X; 84/260 (32.3 %) were XXX, 20/260 (7.7 %) were XX, and 4/260 (1.5 %) were XY. Moreover, skin cells included a mosaic karyotype [47, XXX(29)/46, XX(1)]. We conclude that the collection of a large number of blood lymphocytes can reveal different mosaic patterns (X, XX and XXX) by FISH in spite of non-mosaic Turner syndrome.

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Authors and Affiliations

  1. Iwaki Women’s Clinic, 3-2 Ookishita, Uchigo, Iwaki, Fukushima, 973-8403, Japan

    Nobuo Sugawara & Yasuyuki Kimura

  2. The Institute for Advanced Reproductive Medical Technology, 909-21 Ishii, Fujimi, Maebashi, Gunma, 371-0105, Japan

    Yasuhisa Araki

Authors
  1. Nobuo Sugawara
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  2. Yasuyuki Kimura
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  3. Yasuhisa Araki
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Correspondence to Nobuo Sugawara.

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Sugawara, N., Kimura, Y. & Araki, Y. Case report: a successful pregnancy outcome in a patient with non-mosaic Turner syndrome (45, X) via in vitro fertilization. Human Cell 26, 41–43 (2013). https://doi.org/10.1007/s13577-012-0047-2

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  • DOI: https://doi.org/10.1007/s13577-012-0047-2

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