Abstract
The main objective of this research work is to reveal the detailed and extensive rheological characterization of terpolymeric hydrogel formulations using a variety of monomers having different concentrations of acrylic acid and applying a range of temperatures. The hydrogels with the different concentrations of acrylic acid were prepared in the absence of air using three different monomers, by free radical polymerization, gradually increasing the temperature up to polymerization point, using ethyl alcohol as solvent. Different shear measurements were performed to study rheological properties, temperature dependence, and yield strength of acrylic acid pharmaceutical hydrogels. Various models were applied to analyze the rheological behavior of the gels. The acrylic acid pharmaceutical gels having physical cross links in the gel networks, exhibit remarkable temperature dependence especially with relatively higher concentration of acrylic acid at greater shear rate. Flow curves plotted at various temperatures indicate that these gels exhibit a reasonable pseudoplastic behavior. All these hydrogels require appropriate yield strength to break their network structures. The gel samples exhibit the best fit to the Modified Bingham model, which can explain the overall flow behavior of these topical gels. The rheological analysis indicates that these gels may be used as topical gels for targeted and controlled drug delivery at a specific site.
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Malana, M.A., Zohra, R. & Khan, M.S. Rheological characterization of novel physically crosslinked terpolymeric hydrogels at different temperatures. Korea-Aust. Rheol. J. 24, 155–162 (2012). https://doi.org/10.1007/s13367-012-0019-9
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DOI: https://doi.org/10.1007/s13367-012-0019-9