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Chemokines as Possible Targets in Modulation of the Secondary Damage After Acute Spinal Cord Injury: A Review

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Abstract

In spite of many promising experimental studies, an effective treatment dramatically eliminating the secondary damage after spinal cord injury (SCI) is still missing. Since clinical data on the therapeutical effect after methylprednisolone treatment are not conclusive, new therapeutical modalities targeting specific components of secondary spinal cord damage needs to be developed. It is known that immune cells are recruited to injury sites by chemokines, which are small, structurally similar proteins released locally at the site of inflammation. Hence, this review was aimed to summarize possible roles of chemokines in the inflammation following SCI as well as to identify possible new therapeutical targets which can potentially be effective in ameliorating individual components of this inflammatory response. Data concerning inflammation reduction together with techniques improving axonal growth, cell replacement and remyelinization, may be crucial to move a small step forward in an attempt to make paraplegic and quadriplegic patients to walk.

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Acknowledgment

We thank Professor Martin Maršala, M.D. (Anesthesiology Research Laboratory, University of California, USA) for critically reading the manuscripts and for his useful comments.

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  1. Michal Mokrý

    Present address: Hubrecht Institute for Developmental Biology and Stem Cell Research, The Royal Netherlands Academy of Arts and Sciences, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands

Authors and Affiliations

  1. Institute of Biology and Ecology, Pavol Jozef Šafárik University, Moyzesova 11, 041 80, Košice, Slovak Republic

    Peter Gál

  2. Institute of Neurobiology, Slovak Academy of Sciences, Šoltésovej 4, 040 01, Košice, Slovak Republic

    Petra Kravčuková

  3. Department of Medical Biophysics, Pavol Jozef Šafárik University, Trieda SNP 1, 040 11, Košice, Slovak Republic

    Peter Gál & Michal Mokrý

  4. Department of Anatomy, Pavol Jozef Šafárik University, Šrobárova 2, 041 80, Košice, Slovak Republic

    Darina Kluchová

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  1. Peter Gál
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  2. Petra Kravčuková
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Correspondence to Peter Gál.

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P. Gál and P. Kravčuková contributed equally to this work.

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Gál, P., Kravčuková, P., Mokrý, M. et al. Chemokines as Possible Targets in Modulation of the Secondary Damage After Acute Spinal Cord Injury: A Review. Cell Mol Neurobiol 29, 1025–1035 (2009). https://doi.org/10.1007/s10571-009-9392-4

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