Skip to main content

Advertisement

SpringerLink
Log in

The CNS lesion scar: new vistas on an old regeneration barrier

  • REVIEW
  • Published:
Cell and Tissue Research Aims and scope Submit manuscript

Abstract 

Scar formation represents a reaction of nervous tissue to any form of physical injury. Research over the past decade has demonstrated that the scar composed of glial cells and several extracellular matrix molecules constitutes an obstacle to axon regeneration in the CNS. This review briefly summarizes the current knowledge on (a) the structural and functional features of the lesion scar and (b) the development of therapeutic interventions to override this regeneration barrier.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine University, Moorenstrasse 5, D-40225 Düsseldorf, Germany Tel.: +49 0211 81 17822; Fax: +49 0211 81 18485; e-mail: stichel@uni-duesseldorf.de, , , , , , DE

    C. C. Stichel & Hans Werner Müller

Authors
  1. C. C. Stichel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hans Werner Müller
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Received: 19 June 1998 / Accepted: 23 July 1998

Rights and permissions

Reprints and permissions

About this article

Cite this article

Stichel, C., Müller, H. The CNS lesion scar: new vistas on an old regeneration barrier. Cell Tissue Res 294, 1–9 (1998). https://doi.org/10.1007/s004410051151

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s004410051151

Search

Navigation