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Therapeutic effect of taurine against aluminum-induced impairment on learning, memory and brain neurotransmitters in rats

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Abstract

The aim of the study was to demonstrate the therapeutic effect of taurine against aluminum (Al)-induced neurological disorders in rats. Forty-two Wistar rats were randomly allotted into six groups: control (saline only), Al exposure (281.4 mg/kg/day for 1 month), Al + taurine (Al administration as previously plus taurine, doses were 200, 400 and 800 mg/kg/day, respectively, for the next 1 month) and prevention group (along with the Al administration as previously, 400 mg/kg/day taurine was treated for 1 month. During the next 1 month, rats were given taurine 400 mg/kg/day only). Starting from the sixth week, the body weight gain was significantly reduced in Al exposure group compared with saline (P < 0.05), and at the eighth week, the gain in prevention group was increased compared with Al (P < 0.05). Brain coefficient was gained in Al exposure compared with saline or prevention group (P < 0.05). Al exposure resulted in learning and memory impairment by increasing the escape latency and searching distance, meanwhile, decreasing the swimming time in the quadrant of platform and the numbers of crossing the platform (P < 0.05). Unsurprisingly, taurine treatment (400, 800 mg/kg/day and prevention) significantly protected against Al-induced brain dysfunction (P < 0.05). The Al exposure led to significant decreases in levels of γ-GABA and Tau, meanwhile, increased in level of Asp and Glu compared with saline (P < 0.05). And yet, taurine treatment partially reversed the deteriorated changes. The results suggested that taurine probably has neuroprotective effect against Al-induced learning, memory and brain neurotransmitters dysfunction.

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Acknowledgments

This work was gratefully supported by the College of Public Health, Shandong University, and by Professor Liu ping, my supervisor, for her constant encouragement and guidance. Meanwhile, my thanks would go to my other co-authors, without their help, there would not be the work.

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Authors and Affiliations

  1. Department of Hygiene Detection, College of Public Health, University of Shandong, Jinan, China

    Lu Wenting, Liu Ping, Jiao Haitao, Qiao Meng & Ren Xiaofei

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  1. Lu Wenting
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  2. Liu Ping
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  3. Jiao Haitao
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  4. Qiao Meng
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  5. Ren Xiaofei
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Correspondence to Liu Ping.

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Wenting, L., Ping, L., Haitao, J. et al. Therapeutic effect of taurine against aluminum-induced impairment on learning, memory and brain neurotransmitters in rats. Neurol Sci 35, 1579–1584 (2014). https://doi.org/10.1007/s10072-014-1801-x

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  • DOI: https://doi.org/10.1007/s10072-014-1801-x

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