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Multifunctional enzymes in archaea: promiscuity and moonlight

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Abstract

Enzymes from many archaea colonizing extreme environments are of great interest because of their potential for various biotechnological processes and scientific value of evolution. Many enzymes from archaea have been reported to catalyze promiscuous reactions or moonlight in different functions. Here, we summarize known archaeal enzymes of both groups that include different kinds of proteins. Knowledge of their biochemical properties and three-dimensional structures has proved invaluable in understanding mechanism, application, and evolutionary implications of this manifestation. In addition, the review also summarizes the methods to unravel the extra function which almost was discovered serendipitously. The study of these amazing enzymes will provide clues to optimize protein engineering applications and how enzymes might have evolved on Earth.

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Acknowledgments

Funding for research on moonlighting proteins and other projects has supported by the National Natural Science Foundation of China (31171794, 31201465), Natural Science Foundation of Jilin (201101018), College Students’ Innovative Experiment Project from Jilin University (2012A82219), and New Teacher Foundation from Ministry of Education.

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Authors and Affiliations

  1. College of Plant Sciences, Jilin University, Changchun, 130-062, China

    Baolei Jia & Shihong Zhang

  2. Environmental Biotechnology National Core Research Center, Gyeongsang National University, Jinju, 660-701, Korea

    Gang-Won Cheong

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  1. Baolei Jia
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Correspondence to Baolei Jia.

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Communicated by S. Albers.

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Jia, B., Cheong, GW. & Zhang, S. Multifunctional enzymes in archaea: promiscuity and moonlight. Extremophiles 17, 193–203 (2013). https://doi.org/10.1007/s00792-012-0509-1

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