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Intraductal papillary mucininous neoplasm of the bile ducts: multimodality assessment with pathologic correlation

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Abstract

Mucin-producing intraductal papillary neoplasm (adenocarcinoma/adenoma) in the bile duct is becoming recognized as a specific type of neoplasm. Since, it bears a striking similarity to intraductal papillary mucinous neoplasms of the pancreas with regard to its histopathologic features, the term “intraductal papillary mucinous neoplasms of the bile duct” (IPMN-B) is frequently used, although no definite terminology or definition has been decided by World Health Organization. This neoplasm lacks ovarian-like stroma and communicates with the bile ducts, unlike biliary mucinous cystic neoplasm (MCN). On the other hand, malignant IPMN-B is categorized as an intraductal-growth type of intrahepatic cholangiocarcinoma (ICC). In comparison to other types of ICC, such as the mass-forming type and periductal-infiltrating type that have poor resectability and an unfavorable prognosis, malignant IPMN-B can be resected and demonstrates a more favorable prognosis. Meanwhile, unlike biliary MCN that is usually confined in a closed cyst, IPMN-B can spread along the mucosal surface of the bile ducts, and it should be widely resected. Therefore, multimodality assessment is needed to ensure the correct diagnosis of IPMN-B. We herein review the imaging findings of IPMN-B with pathologic correlation.

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Authors and Affiliations

  1. Department of Diagnostic Radiology, Tohoku University Graduate School of Medicine, Seiryomachi, 1-1, Aoba-ku, Sendai, 980-8574, Japan

    Kentaro Takanami, Masashi Tsuda, Kei Takase & Shoki Takahashi

  2. Department of Radiology, Sendai City Hospital, Wakabayashi-ku, Shimizukouji 3-1, Sendai, Japan

    Takayuki Yamada

  3. Department of Pathology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan

    Kazuyuki Ishida & Yasuhiro Nakamura

  4. Division of Gastroenterology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan

    Atsushi Kanno & Tooru Shimosegawa

  5. Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan

    Michiaki Unno

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  1. Kentaro Takanami
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  2. Takayuki Yamada
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Correspondence to Kentaro Takanami.

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Takanami, K., Yamada, T., Tsuda, M. et al. Intraductal papillary mucininous neoplasm of the bile ducts: multimodality assessment with pathologic correlation. Abdom Imaging 36, 447–456 (2011). https://doi.org/10.1007/s00261-010-9649-x

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