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Hypoxia in Tumours: Its Relevance, Identification, and Modification

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Current Topics in Clinical Radiobiology of Tumors

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

It is well known that cells irradiated under conditions of oxygen deprivation are more resistant to sparsely ionizing radiation than well-oxygenated cells (Hall 1988). Additional studies have now shown that oxygen-deficient cells exist in most animal solid tumours (Guichard et al. 1980; Moulder and Rockwell 1984). There is strong evidence to suggest that hypoxic cells can also be found in human tumours and that they are probably one of the major reasons for failure to locally control certain tumor types with conventional radiation therapy (Dische 1989; Overgaard 1989).

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Authors and Affiliations

  1. Department of Experimental Clinical Oncology, Danish Cancer Society, Nørrebrogade 44, DK-8000, Aarhus C, Denmark

    M. R. Horsman PhD

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  1. M. R. Horsman PhD
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  1. Institut für Biophysik und Strahlenbiologie, Universität Hamburg, Martinistraße 52, 20246, Hamburg, Germany

    Hans-Peter Beck-Bornholdt

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© 1993 Springer-Verlag Berlin Heidelberg

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Horsman, M.R. (1993). Hypoxia in Tumours: Its Relevance, Identification, and Modification. In: Beck-Bornholdt, HP. (eds) Current Topics in Clinical Radiobiology of Tumors. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84918-3_9

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  • DOI: https://doi.org/10.1007/978-3-642-84918-3_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84920-6

  • Online ISBN: 978-3-642-84918-3

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