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Hypoxia and Gene Expression

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Hypoxia and Cancer

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

Analysis of gene expression is a promising approach to understand tumor hypoxia and to relate biology to prognosis and response to therapy. Understanding the response to hypoxia of every component of the tumor mass is indispensable to understand the biology of the system. However, the plasticity and distribution of hypoxic areas make it difficult to gauge tumor hypoxia by combining the information of individual components. Global information on tumor gene expression revealed by the analysis of the transcriptome of the tumor mass provides a global view of the hypoxic status of the tissue. The global and analytic assessment of tumor hypoxia, revealed by the whole tumor mass or by its individual components, will be discussed with particular emphasis on tumor-infiltrating leukocytes.

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Authors and Affiliations

  1. Laboratory of Molecular Biology, Gaslini Institute, Largo Gaslini 5, 16147, Genoa, Italy

    Maria Carla Bosco & Luigi Varesio

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  1. Maria Carla Bosco
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  2. Luigi Varesio
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Correspondence to Maria Carla Bosco .

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  1. Bristol-Myers Squibb, Princeton, New Jersey, USA

    Giovanni Melillo

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Bosco, M., Varesio, L. (2014). Hypoxia and Gene Expression. In: Melillo, G. (eds) Hypoxia and Cancer. Cancer Drug Discovery and Development. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9167-5_5

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