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Nutritive und toxische Neuropathien

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Pathologie

Zusammenfassung

Zu den nutritiven Neuropathien gehören einerseits die Vitaminmangelneuropathien, einschließlich der alkoholischen Neuropathie. Abzugrenzen sind davon toxische Neuropathien, die einerseits durch Gewerbe- und Umweltgifte bedingt sind, vielfach aber auf medikamentöse Nebenwirkungen zurückzuführen sind. Wegen der großen Zahl neurotoxischer Substanzen werden nur die morphologischen Auswirkungen einiger ausgewählter Neurotoxine dargestellt, die Modellcharakter haben und zur Erweiterung unserer Kenntnisse von der Pathogenese peripherer Neuropathien geführt haben. Im einzelnen sind es: Chlorierte Kohlenwasserstoffe wie z. B. Trichlorethylen; Metalle wie Arsen, Blei, Quecksilber, Thallium, Cadmium, Platin und Gold; Kohlenwasserstoffe wie Acrylamid, Hexacarbone und Schwefelkohlenstoff; Kohlenmonoxid, Ethylenoxid, Diaminoproprionitril, Iminodiproprionitril; organische Phosphorverbindungen; Tetrachlorkohlenstoff, Dichlorbenzol und Pentachlorphenol, Hexachlorophen, polychlorierte Biphenyle, DDT, Dichlorphenoxyessigsäure; Medikamente wie Chloroquin, Isonikotinsäurehydrazid (INH), Amiodaron; Taxol; Thalidomid, Tryptophan; hohmolekulare Substanzen wie Polyvinylpyrrolidon und Dextrane; Heroin. Abschließend wird das mutiple Chemikalien-Sensitivitäts (MCS)-Syndrom diskutiert.

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  1. Institut für Neuropathologie, Universitätsklinikum der Rheinisch-Westfälischen Technischen Hochschule (RWTH) Aachen, Pauwelsstraße 30, 52074, Aachen, Deutschland

    J. Michael Schröder

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  1. Institut für Pathologie Konsultationszentrum für Pankreas- und Endokrine Tumore, TU München, Ismaninger Straße 22, 81675, München, Deutschland

    Günter Klöppel (Werkherausgeber) (Werkherausgeber)

  2. Zentrum Pathologie und Rechtsmedizin, Medizinische Hochschule Hannover (MHH), Carl-Neuberg-Straße 1, 30625, Hannover, Deutschland

    Hans H. Kreipe (Werkherausgeber) (Werkherausgeber)

  3. Institut für Pathologie, Kliniken der Landeshauptstadt, Ludwig-Erhard-Straße 100, 65199, Wiesbaden, Deutschland

    Wolfgang Remmele (Werkherausgeber) (Werkherausgeber)

  4. Institut für Neuropathologie, Universitätsklinikum Münster, Domagkstraße 19, 48149, Münster, Deutschland

    Werner Paulus (Bandherausgeber) (Bandherausgeber)

  5. Institut für Neuropathologie, Universitätsklinikum der Rheinisch-Westfälischen Technischen Hochschule (RWTH) Aachen, Pauwelsstraße 30, 52074, Aachen, Deutschland

    J. Michael Schröder (Bandherausgeber) (Bandherausgeber)

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Schröder, J. (2012). Nutritive und toxische Neuropathien. In: Klöppel, G., Kreipe, H., Remmele, W., Paulus, W., Schröder, J. (eds) Pathologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02324-8_21

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