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Great Promise of Tissue-Resident Adult Stem/Progenitor Cells in Transplantation and Cancer Therapies

  • Chapter
Stem Cell Transplantation

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 741))

Abstract

Recent progress in tissue-resident adult stem/progenitor cell research has inspired great interest because these immature cells from your own body can act as potential, easily accessible cell sources for cell transplantation in regenerative medicine and cancer therapies. The use of adult stem/progenitor cells endowed with a high self-renewal ability and multilineage differentiation potential, which are able to regenerate all the mature cells in the tissues from their origin, offers great promise in replacing non-functioning or lost cells and regenerating diseased and damaged tissues. The presence of a small subpopulation of adult stem/progenitor cells in most tissues and organs provides the possibility of stimulating their in vivo differentiation, or of using their ex vivo expanded progenies for cell-replacement and gene therapies with multiple applications in humans without a high-risk of graft rejection and major side effects. Among the diseases that could be treated by adult stem cell-based therapies are hematopoietic and immune disorders, multiple degenerative disorders such as Parkinson’s and Alzheimer’s diseases, Types 1 and 2 diabetes mellitus as well as skin, eye, liver, lung, tooth and cardiovascular disorders. In addition, a combination of the current cancer treatments with an adjuvant treatment consisting of an autologous or allogeneic adult stem/progenitor cell transplantation also represents a promising strategy for treating and even curing diverse aggressive, metastatic, recurrent and lethal cancers. In this chapter, we reviewed the most recent advancements on the characterization of phenotypic and functional properties of adult stem/progenitor cell types found in bone marrow, heart, brain and other tissues and discussed their therapeutic implications in the stem cell-based transplantation therapy.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA

    Murielle Mimeault & Surinder K. Batra

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  1. Murielle Mimeault
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  2. Surinder K. Batra
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Correspondence to Murielle Mimeault .

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  1. Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain

    Carlos López-Larrea PhD , Antonio López-Vázquez MD  & Beatriz Suárez-Álvarez PhD ,  & 

  2. Fundación Renal Iñigo Alvarez de Toledo, Madrid, Spain

    Carlos López-Larrea PhD

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Mimeault, M., Batra, S.K. (2012). Great Promise of Tissue-Resident Adult Stem/Progenitor Cells in Transplantation and Cancer Therapies. In: López-Larrea, C., López-Vázquez, A., Suárez-Álvarez, B. (eds) Stem Cell Transplantation. Advances in Experimental Medicine and Biology, vol 741. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-2098-9_12

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