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Caveolins in Cancer Pathogenesis, Prevention and Therapy pp 75–90Cite as

Caveolins in Tumor Angiogenesis

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Part of the book series: Current Cancer Research ((CUCR))

Abstract

Angiogenesis is essential for tumor growth and metastasis. Caveolin proteins, in particular Caveolin-1, are increasingly recognized for their ability to regulate multiple signaling pathways in various tissues and cell types. A large body of evidence based on mouse models of tumor-induced angiogenesis in vivo as well as in vitro assays of angiogenesis along with relevant endothelial cell signaling, all point to the importance for Caveolin-1 in angiogenesis. Clinical data correlating Caveolin-1 expression with tumor microvascular density and progression further support the notion that Caveolin-1 may play an important role in tumor angiogenesis. Although direct evidence is lacking, there is a limited amount of data implying that Caveolin-2, which is the major interacting partner of Caveolin-1, could potentially also be involved in modulating tumor angiogenesis. The purpose of this chapter is to summarize existing basic and clinical research studies examining the role of caveolins, in particular Caveolin-1 in tumor angiogenesis.

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Acknowledgments

Work in the author’s laboratory on this topic is supported by the grant from the National Institute of Health (1R01HL081860 to GS).

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Authors and Affiliations

  1. Department of Medical Pharmacology and Physiology, University of Missouri, 1 Hospital Drive, Rm. MA 415, Columbia, MO, 65212, USA

    Grzegorz Sowa

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  1. Grzegorz Sowa
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Correspondence to Grzegorz Sowa .

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Editors and Affiliations

  1. Kimmel Cancer Center, Thomas Jefferson University, S. 10th Street 233, Philadelphia, 19107, Pennsylvania, USA

    Isabelle Mercier

  2. Bluemle Bldg, Rm 939, Department of Stem Cell Biology and Rege, Thomas Jefferson University, S. 10th Street 233, Philadelphia, 19107, Pennsylvania, USA

    Jean-François Jasmin

  3. Kimmel Cancer Center, Thomas Jefferson University, S. 10th Street 233, Philadelphia, 19107, Pennsylvania, USA

    Michael P. Lisanti

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Sowa, G. (2012). Caveolins in Tumor Angiogenesis. In: Mercier, I., Jasmin, JF., Lisanti, M. (eds) Caveolins in Cancer Pathogenesis, Prevention and Therapy. Current Cancer Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1001-0_6

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  • DOI: https://doi.org/10.1007/978-1-4614-1001-0_6

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-1000-3

  • Online ISBN: 978-1-4614-1001-0

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