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Overexpression of Caveolin-1 in Hepatocellular Carcinoma with Metastasis and Worse Prognosis: Correlation with Vascular Endothelial Growth Factor, Microvessel Density and Unpaired Artery

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  • Published:
Pathology & Oncology Research

Abstract

Caveolin-1 is the major structural protein in caveolae, implicated in oncogenesis and angiogenesis. The connections between caveolin-1 and progression and angiogenesis of hepatocellular carcinoma (HCC) is still not clear. Thus we investigated the relationship of caveolin-1 expression, vascular endothelial growth factor (VEGF) expression, microvessel density (MVD), and unpaired artery (UA) with the clinicopathologic features of patients with HCC. Formalin-fixed, paraffin-embedded tissue sections of HCC from 75 patients who had undergone an initial hepatectomy were stained immunohistochemically with specific antibodies against caveolin-1, VEGF, CD34 and α-SMA. The levels of caveolin-1, VEGF, MVD and UA were correlated with the clinicopathologic variables, and tissue sections were also analyzed by dual-label immunofluorescence. We found that increased expression of caveolin-1 was associated with metastasis and with a worse prognosis of HCC. Caveolin-1 expression correlates positively with VEGF, MVD and UA. These results suggest that caveolin-1 may play an important role in the progression of HCC and angiogenesis.

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Abbreviations

HCC:

hepatocellular carcinoma

MVD:

microvessel density

UA:

unpaired artery

VEGF:

vascular endothelial growth factor

α-SMA:

alpha smooth muscle actin

SECs:

sinusoidal endothelial cells

MDN:

macroregenerative and dysplastic nodules

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Acknowledgements

Special thanks to Dr. Lin-Ying Chen for technical assistance.

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Authors and Affiliations

  1. Institute of Hepatobiliary Surgery & Southwest Hospital, Third Military Medical University, Chongqing, 400038, People’s Republic of China

    Zhi-Bo Zhang, Lei Cai, Shu-Guo Zheng, Yan Xiong & Jia-Hong Dong

  2. Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350004, People’s Republic of China

    Zhi-Bo Zhang

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  1. Zhi-Bo Zhang
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  2. Lei Cai
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Correspondence to Jia-Hong Dong.

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Zhang, ZB., Cai, L., Zheng, SG. et al. Overexpression of Caveolin-1 in Hepatocellular Carcinoma with Metastasis and Worse Prognosis: Correlation with Vascular Endothelial Growth Factor, Microvessel Density and Unpaired Artery. Pathol. Oncol. Res. 15, 495–502 (2009). https://doi.org/10.1007/s12253-008-9144-7

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  • DOI: https://doi.org/10.1007/s12253-008-9144-7

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