Skip to main content
SpringerLink
Log in

Coats’ Disease

  • Chapter
  • First Online:
Retinal Vascular Disease

Part of the book series: Retina Atlas ((RA))

  • 568 Accesses

Abstract

Coats’ disease is a pediatric vitreoretinopathy that is characterized by the presence of idiopathic retinal vascular telangiectasias with possible retinal exudation and exudative retinal detachments (Shields and Shields 2001). It was first described by George Coats in 1908 as a disease entity with retinal exudation and vascular anomalies (Coats 1908). In 1912, a similar condition characterized by multiple retinal aneurysms and retinal degeneration was reported by Theodor Leber and was named Leber’s miliary aneurysm (Leber 1912). In 1956, Reese observed that patients with the condition described by Leber eventually progressed to the clinical appearance reported by Coats. He then further pointed out the similarities between both conditions and suggested that the term Coats’ disease was used to describe both entities (Reese 1956).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  • Bergstrom CS, Hubbard GB 3rd. Combination intravitreal triamcinolone injection and cryotherapy for exudative retinal detachments in severe Coats disease. Retina. 2008 Mar;28(3 Suppl):S33–7.

    Article  PubMed  Google Scholar 

  • Bhat V, D'Souza P, Shah PK, Narendran V. Risk of Tractional retinal detachment following Intravitreal Bevacizumab along with subretinal fluid drainage and Cryotherapy for stage 3B Coats’ disease. Middle East Afr J Ophthalmol. 2016 Apr-Jun;23(2):208–11.

    Article  PubMed  PubMed Central  Google Scholar 

  • Blair MP, Ulrich JN, Elizabeth Hartnett M, Shapiro MJ. Peripheral retinal nonperfusion in fellow eyes in coats disease. Retina. 2013 Sep;33(8):1694–9.

    Article  PubMed  Google Scholar 

  • Coats G. Forms of retinal disease with massive exudation. R Lond Ophthalmic Hosp Rep. 1908;17:440–525.

    Google Scholar 

  • Daruich A, Matet A, Tran HV, Gaillard MC, Munier FL. Extramacular fibrosis in Coats’ disease. Retina. 2016 Oct;36(10):2022–8.

    Article  PubMed  Google Scholar 

  • Daruich AL, Moulin AL, Tran HV, Matet A, Munier FL. Subfoveal nodule in Coats’ disease: toward an updated classification predicting visual prognosis. Retina. 2016;0:1–8.

    Google Scholar 

  • Fernandes BF, Odashiro AN, Maloney S, Zajdenweber ME, Lopes AG, Burnier MN Jr. Clinical-histopathological correlation in a case of Coats’ disease. Diagn Pathol. 2006 Aug 30;1:24.

    Article  PubMed  PubMed Central  Google Scholar 

  • Gaillard MC, Mataftsi A, Balmer A, Houghton S, Munier FL. Ranibizumab in the management of advanced Coats disease stages 3B and 4: long-term outcomes. Retina. 2014 Nov;34(11):2275–81.

    Article  CAS  PubMed  Google Scholar 

  • Ghazi NG, Al Shamsi H, Larsson J, Abboud E. Intravitreal triamcinolone in Coats’ disease. Ophthalmology. 2012 Mar;119(3):648–9.

    Article  PubMed  Google Scholar 

  • Gomez Morales A. Coats’ disease. Natural history and results of treatment. Am J Ophthalmol. 1965 Nov;60(5):855–65.

    Article  CAS  PubMed  Google Scholar 

  • Harris GS. Coats’ disease, diagnosis and treatment. Can J Ophthalmol. 1970 Oct;5(4):311–20.

    CAS  PubMed  Google Scholar 

  • He YG, Wang H, Zhao B, Lee J, Bahl D, McCluskey J. Elevated vascular endothelial growth factor level in Coats’ disease and possible therapeutic role of bevacizumab. Graefes Arch Clin Exp Ophthalmol. 2010 Oct;248(10):1519–21.

    Article  CAS  PubMed  Google Scholar 

  • Imre G. Coats’ disease and hyperlipemic retinitis. Am J Ophthalmol. 1967 Oct;64(4):726–33.

    Article  CAS  PubMed  Google Scholar 

  • Kase S, Rao NA, Yoshikawa H, Fukuhara J, Noda K, Kanda A, Ishida S. Expression of vascular endothelial growth factor in eyes with Coats’ disease. Invest Ophthal Vis Sci. 2012;54(1):57–62.

    Article  CAS  Google Scholar 

  • Leber T. Ueber eine durch Vorkommen multipler Miliaraneurysmen charakterisierteForm von Retinaldegeneration. Albrecht von Graefe's Arch Klin Ophthalmol. 1912;81:1–14.

    Article  Google Scholar 

  • Levinson JD, Hubbard GB 3rd. 577-nm yellow laser photocoagulation for Coats disease. Retina. 2016 Jul;36(7):1388–94.

    Article  CAS  PubMed  Google Scholar 

  • Lin CJ, Chen SN, Hwang JF, Yang CM. Combination treatment of pediatric coats’ disease: a bicenter study in Taiwan. J Pediatr Ophthalmol Strabismus. 2013 Nov-Dec;50(6):356–62.

    Article  PubMed  Google Scholar 

  • Morris B, Foot B, Mulvihill A. A population-based study of Coats’ disease in the United Kingdom I: epidemiology and clinical features at diagnosis. Eye. 2010;24:1797–801.

    Article  CAS  PubMed  Google Scholar 

  • Mrejen S, Metge F, Denion E, Dureau P, Edelson C, Caputo G. Management of retinal detachment in Coats disease. Study of 15 cases. Retina. 2008 Mar;28(3 Suppl):S26–32.

    Article  PubMed  Google Scholar 

  • Ong SS, Buckley EG, McCuen BW 2nd, Jaffe GJ, Postel EA, Mahmoud TH, Stinnett SS, Toth CA, Vajzovic L, Mruthyunjaya P. Comparison of visual outcomes in Coats’ disease: a 20-year experience. Ophthalmology. 2017 Sep;124(9):1368–76.

    Article  PubMed  Google Scholar 

  • Othman IS, Moussa M, Bouhaimed M. Management of lipid exudates in Coats disease by adjuvant intravitreal triamcinolone: effects and complications. Br J Ophthalmol. 2010 May;94(5):606–10.

    Article  PubMed  Google Scholar 

  • Ramasubramanian A, Shields CL. Bevacizumab for Coats’ disease with exudative retinal detachment and risk of vitreoretinal traction. Br J Ophthalmol. 2012 Mar;96(3):356–9.

    Article  PubMed  Google Scholar 

  • Ray R, Baranano DE, Hubbard GB. Treatment of Coats’ disease with intravitreal bevacizumab. Br J Ophthalmol. 2013 Mar;97(3):272–7.

    Article  PubMed  Google Scholar 

  • Reese AB. Telangiectasis of the retina and Coats’ disease. Am J Ophthalmol. 1956 Jul;42(1):1–8.

    Article  CAS  PubMed  Google Scholar 

  • Ridley ME, Shields JA, Brown GC, Tasman W. Coats’ disease. Evaluation of management Ophthalmology. 1982 Dec;89(12):1381–7.

    CAS  PubMed  Google Scholar 

  • Sally S. Ong, Thomas J. Cummings, Lejla Vajzovic, Prithvi Mruthyunjaya, Cynthia A. Toth. Comparison of Optical Coherence Tomography With Fundus Photographs, Fluorescein Angiography, and Histopathologic Analysis in Assessing Coats Disease. JAMA Ophthalmology. 2019;137(2):176.

    Google Scholar 

  • Schefler AC, Berrocal AM, Murray TG. Advanced Coats’ disease. Management with repetitive aggressive laser ablation therapy. Retina. 2008 Mar;28(3 Suppl):S38–41.

    Article  PubMed  Google Scholar 

  • Schmidt-Erfurth U, Lucke K. Vitreoretinal surgery in advanced Coat’s disease. Ger J Ophthalmol. 1995 Jan;4(1):32–6.

    CAS  PubMed  Google Scholar 

  • Sein J, Tzu JH, Murray TG, Berrocal AM. Treatment of Coats’ disease with combination therapy of Intravitreal Bevacizumab, laser photocoagulation, and sub-Tenon corticosteroids. Ophthalmic Surg Lasers Imaging Retina. 2016;47:443–9.

    Article  PubMed  Google Scholar 

  • Shapiro MJ, Chow CC, Karth PA, Kiernan DF, Blair MP. Effects of green diode laser in the treatment of pediatric Coats’ disease. Am J Ophthal. 2011;151(4):725–31.

    Article  PubMed  Google Scholar 

  • Shields J, Shields C. Review: coats disease, the 2001 LuEsther T. Mertz Lecture Retina. 2001;22(1):80–91.

    Article  Google Scholar 

  • Shields JA, Shields CL, Honavar SG, Demirci H. Clinical variations and complications of Coats disease in 150 cases: the 2000 Sanford Gifford memorial lecture. Am J Ophthalmol. 2001 May;131(5):561–71.

    Article  CAS  PubMed  Google Scholar 

  • Shields JA, Shields CL, Honavar SG, Demirci H, Cater J. Classification and management of Coats disease: the 2000 proctor lecture. Am J Ophthalmol. 2001 May;131(5):572–83.

    Article  CAS  PubMed  Google Scholar 

  • Sigler EJ, Randolph JC, Calzada JI, Wilson MW, Haik BG. Current management of Coats disease. Surv Ophthalmol. 2014 Jan-Feb;59(1):30–46.

    Article  PubMed  Google Scholar 

  • Silodor SW, Augsburger JJ, Shields JA, Tasman W. Natural history and management of advanced Coats’ disease. Ophthalmic Surg. 1988 Feb;19(2):89–93.

    CAS  PubMed  Google Scholar 

  • Sun Y, Jain A, Moshfeghi DM. Elevated vascular endothelial growth factor levels in Coats disease: rapid response to pegaptanib sodium. Graefes Arch Clin Exp Ophthalmol. 2007 Sep;245(9):1387–8.

    Article  CAS  PubMed  Google Scholar 

  • Tarkkanen A, Laatikainen L. Coats’ disease: clinical, angiographic, histopathological findings and clinical management. Br J Ophthal. 1983;67:766–76.

    Article  CAS  Google Scholar 

  • Tripathi R, Ashton N. Electron microscopical study of Coats’ disease. Br J Ophthal. 1971;55(5):289–301.

    Article  CAS  Google Scholar 

  • Villegas VM, Gold AS, Berrocal AM, Murray TG. Advanced Coats’ disease treated with intravitreal bevacizumab combined with laser vascular ablation. Clin Ophthalmol. 2014;8:973–6.

    PubMed  PubMed Central  Google Scholar 

  • Yannuzzi LA, Bardal AM, Freund KB, Chen KJ, Eandi CM, Blodi B. Idiopathic macular telangiectasia. Arch Ophthalmol. 2006 Apr;124(4):450–60.

    Article  PubMed  Google Scholar 

  • Yoshizumi MO, Kreiger AE, Lewis H, Foxman B, Hakakha BA. Vitrectomy techniques in late-stage Coats’-like exudative retinal detachment. Doc Ophthalmol. 1995;90(4):387–94.

    Article  CAS  PubMed  Google Scholar 

  • Zhang H, Liu ZL. Increased nitric oxide and vascular endothelial growth factor levels in the aqueous humor of patients with coats’ disease. J Ocul Pharmacol Ther. 2012 Aug;28(4):397–401.

    Article  PubMed  CAS  Google Scholar 

  • Zhao Q, Peng XY, Chen FH, Zhang YP, Wang L, You QS, Jonas JB. Vascular endothelial growth factor in Coats’ disease. Acta Ophthalmol. 2014 May;92(3):e225–8.

    Article  PubMed  Google Scholar 

  • Zheng X, Jiang Y. The effect of intravitreal bevacizumab injection as the initial treatment for Coats’ disease. Graefes Arch Clin Exp Ophthalmol. 2014;252:35–42.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Wilmer Eye Institute, Baltimore, MD, USA

    Sally S. Ong

  2. Johns Hopkins University, Baltimore, MD, USA

    Sally S. Ong

  3. Department of Ophthalmology, Duke University, Durham, NC, USA

    Lejla Vajzovic

Authors
  1. Sally S. Ong
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lejla Vajzovic
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Lejla Vajzovic .

Editor information

Editors and Affiliations

  1. New York Eye and Ear Infirmary of Mount Sinai, New York, NY, USA

    Alan Sheyman

  2. Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

    Amani A. Fawzi

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Ong, S.S., Vajzovic, L. (2020). Coats’ Disease. In: Sheyman, A., Fawzi, A.A. (eds) Retinal Vascular Disease. Retina Atlas. Springer, Singapore. https://doi.org/10.1007/978-981-15-4075-2_7

Download citation

  • DOI: https://doi.org/10.1007/978-981-15-4075-2_7

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-15-4074-5

  • Online ISBN: 978-981-15-4075-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation