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Elevated vascular endothelial growth factor levels in Coats disease: rapid response to pegaptanib sodium

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Abstract

Purpose

The purpose was to report a case of elevated intraocular vascular endothelial growth factor (VEGF) levels in a 2-year-old boy with stage 4 Coats disease.

Design

Interventional case report.

Methods

A 2-year-old boy with severe Coats disease and complex retinal detachment refractory to surgical intervention underwent two injections of intravitreal pegaptanib sodium in his right eye 8 weeks apart.

Results

After intravitreal injection there was a marked reduction in VEGF (908 to 167 pg/ml) levels and improvement of exudation, hemorrhage, and nearly complete reattachment of his retina within 3 weeks of treatment. The patient remains stable 6 months post-treatment.

Conclusions

Coats disease may have a component of dysregulation of VEGF-mediated angiogenesis as evidenced by elevated levels in this patient.

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, Stanford University, 300 Pasteur Drive, Room A-157, Stanford, CA, 94305, USA

    Young Sun, Atul Jain & Darius M. Moshfeghi

Authors
  1. Young Sun
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  2. Atul Jain
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  3. Darius M. Moshfeghi
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Corresponding author

Correspondence to Darius M. Moshfeghi.

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Sun, Y., Jain, A. & Moshfeghi, D.M. Elevated vascular endothelial growth factor levels in Coats disease: rapid response to pegaptanib sodium. Graefes Arch Clin Exp Ophthalmol 245, 1387–1388 (2007). https://doi.org/10.1007/s00417-007-0559-8

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  • DOI: https://doi.org/10.1007/s00417-007-0559-8

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