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Alginate Microcapsules for Drug Delivery

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Alginates and Their Biomedical Applications

Part of the book series: Springer Series in Biomaterials Science and Engineering ((SSBSE,volume 11))

Abstract

Currently, conventional drug delivery systems do not provide adequate therapeutic profiles for the management of multiple diseases. In this regard, cell encapsulation technology emerges as a suitable alternative. Undoubtedly, one of the most employed biomaterials for this purpose is alginate, since it presents multiple advantages that favor the development of this technology. Importantly, the thorough study concerning the purification and modification of the polymer has led to biocompatible alginates, a vital advancement for the correct function of the system. Furthermore, the possibility to entrap different cell types together with the plausibility of engineering cells to produce disparate therapeutic biomolecules has given rise to numerous applications. That is the case of relevant and prevalent diseases nowadays such as diabetes, cancer, or neurological diseases. Intensive research in the field has resulted in promising preclinical studies in animal models that have instigated the conduction of several clinical trials. Nonetheless, addressing some current challenges regarding aspects such as biosafety or biofunctionalization seems to be a prerequisite before the clinical translation.

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Acknowledgments

A. Gonzalez-Pujana thanks the Basque Government (Department of Education, Universities and Research) for the PhD fellowship. This project was partially supported by the Basque Government (Consolidated Groups, IT-907-16) and the University of the Basque Country UPV/EHU (UFI11/32).

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  1. Both, Edorta Santos-Vizcaino and Rosa Maria Hernandez are corresponding authors.

Authors and Affiliations

  1. NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country UPV/EHU, Vitoria, Spain

    Ainhoa Gonzalez-Pujana, Gorka Orive, Jose Luis Pedraz, Edorta Santos-Vizcaino & Rosa Maria Hernandez

  2. Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Vitoria, Spain

    Ainhoa Gonzalez-Pujana, Gorka Orive, Jose Luis Pedraz, Edorta Santos-Vizcaino & Rosa Maria Hernandez

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  1. Ainhoa Gonzalez-Pujana
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  4. Edorta Santos-Vizcaino
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Correspondence to Edorta Santos-Vizcaino or Rosa Maria Hernandez .

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Editors and Affiliations

  1. Centre for Cell Factories and Biopolymers, Griffith Institute for Drug Discovery, Griffith University, Brisbane, Queensland, Australia

    Bernd H.A. Rehm

  2. Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, Florida, USA

    M. Fata Moradali

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Gonzalez-Pujana, A., Orive, G., Pedraz, J.L., Santos-Vizcaino, E., Hernandez, R.M. (2018). Alginate Microcapsules for Drug Delivery. In: Rehm, B., Moradali, M. (eds) Alginates and Their Biomedical Applications. Springer Series in Biomaterials Science and Engineering, vol 11. Springer, Singapore. https://doi.org/10.1007/978-981-10-6910-9_3

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