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Retinoic Acid Receptor-β, From Gene to Clinic

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Epigenetics Territory and Cancer

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Abstract

Retinoic acid receptor-beta (RAR-β) is nuclear receptor which can be activated by corresponding ligands, including retinoic acid. It is encoded by RARB gene, which is conserved in several species, and code for a DNA binding protein that in complex to the ligand and other binding partners binds to specific sites and regulates the expression of several genes. RAR-β plays important roles in several developmental, physiologic, and pathogenic mechanisms in human. It is a tumor suppressor gene, which is not expressed in several cancers. Methylation status and micro-RNAs are key central regulators of the RARB expression, which are influenced by several factors, such as environment and diet. It is responsible for the induction of apoptosis, and for the chemo-preventive and therapeutic effects of anti-cancer drugs, therefor has been used a treatment against different kinds of cancer in several clinical trials.

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Authors and Affiliations

  1. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Poursina Street, P.O. Box: 14176-13151, Keshavarz Boulevard Tehran, Iran

    Prof. Dr. Parvin Mehdipour

  2. Instituto de Neurociencias CSIC-UMH, Avda. Ramon y Cajal s/n, 03550, San Juan de Alicante, Spain

    Hassan Fazilaty

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Correspondence to Parvin Mehdipour .

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  1. Tehran University of Medical Sciences, Department of Medical Genetics School Of Medicine, Tehran, Iran

    Parvin Mehdipour

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Fazilaty, H., Mehdipour, P. (2015). Retinoic Acid Receptor-β, From Gene to Clinic. In: Mehdipour, P. (eds) Epigenetics Territory and Cancer. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9639-2_12

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