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Mechanisms of Brain Morphogenesis

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Computer Models in Biomechanics

Abstract

In structures with obvious mechanical function, like the heart and bone, the relationship of mechanical forces to growth and development has been well studied. In contrast, other than the problem of neurulation, the developmental mechanisms in the nervous system have received relatively little attention. In this review we discuss recent advances in our understanding of the physical mechanisms of morphogenesis during brain development. Specifically, we focus on two processes: formation of the primary brain vesicles and folding of the cerebral cortex.

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Acknowledgements

We gratefully acknowledge funding support from NIH grants R01 GM075200 and R01 NS070918 (LAT), as well as a fellowship for BAF from NIH T90 DA022871 and the Mallinckrodt Institute of Radiology, Washington University.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Washington University, St. Louis, MO, 63130, USA

    Benjamen A. Filas & Larry A. Taber

  2. Department of Mechanical Engineering and Materials Science, Washington University, St. Louis, MO, 63130, USA

    Gang Xu

Authors
  1. Benjamen A. Filas
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  2. Gang Xu
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  3. Larry A. Taber
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Corresponding author

Correspondence to Larry A. Taber .

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Editors and Affiliations

  1. Institute of Biomechanics, Center of Biomedical Engineering, Graz University of Technology, Kronegasse 5-I, Graz, 8010, Austria

    Gerhard A. Holzapfel

  2. Dept. Mechanical Engineering, Dept. of Bioengineering (courtesy), Stanford University, Lomita Mall 496, Stanford, 94305-4040, California, USA

    Ellen Kuhl

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Filas, B.A., Xu, G., Taber, L.A. (2013). Mechanisms of Brain Morphogenesis. In: Holzapfel, G., Kuhl, E. (eds) Computer Models in Biomechanics. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5464-5_24

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  • DOI: https://doi.org/10.1007/978-94-007-5464-5_24

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-5463-8

  • Online ISBN: 978-94-007-5464-5

  • eBook Packages: EngineeringEngineering (R0)

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