Skip to main content
SpringerLink
Log in

Nicotinic Ganglion-Stimulating Agents

  • Chapter
Pharmacology of Ganglionic Transmission

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 53))

Abstract

The classic subgrouping of cholinoceptive sites proposed by Dale is based on the different pharmacological properties of muscarine and nicotine. Stated in the simplest terms, a drug is said to be a nicotinic agonist when it causes the general bi-phasic pattern of excitation and depression of excitable tissues that is produced by nicotine. More rigorous definitions of nicotinic agonists include susceptibility to blockade by specific antagonists, of which hexamethonium and d-tubocurarine can be regarded as prototypical drugs. It is generally understood that the responses to nicotinic agents are resistant to blockade by atropine or adrenergic blocking drugs. It is in this context that the term nicotinic agent is used in this chapter.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Alkadhi, K.A., McIsaac, R.J.: Effect of preganglionic nerve stimulation on the sensitivity of the superior cervical ganglion to nicotine blocking agents. Br. J. Pharmacol. 51, 533–539 (1974)

    PubMed  CAS  Google Scholar 

  • Ambache, N., Perry, W.L.M., Robertson, P.A.: The effect of muscarine on perfused superior cervical ganglia of cats. Br. J. Pharmacol. 11, 442–448 (1956)

    CAS  Google Scholar 

  • Armett, C.J., Ritchie, J.M.: The action of acetylcholine and some related substances on conduction in mammalian non-myelinated nerve fibres. J. Physiol. (Lond.) 155, 372–384 (1961)

    CAS  Google Scholar 

  • Axelsson, J., Thesleff, S.: A study of supersensitivity in denervated mammalian skeletal muscle. J. Physiol. (Lond.) 147, 178–193 (1959)

    CAS  Google Scholar 

  • Baker, P.F., Connelly, C.M.: Some properties of the external activation site of the sodium pump in crab nerve. J. Physiol. (Lond.) 185, 270–297 (1966)

    CAS  Google Scholar 

  • Beleslin, D.B., Malobabic, Z.S.: Cholinoceptive sites in the ganglia of myenteric plexus subserving the peristaltic reflex of guinea-pig isolated ileum. Neuropharmacology 13, 1091–1094 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Benoit, P.N., Audibert-Benoit, M.L., Peyrot, M.: Importance des effets presynaptiques dans le blocage de la jonction neuromusculaire de grenouille par substitution du lithium au sodium dans le milieu de survie. Arch. Ital. Biol. 3, 323–335 (1973)

    Google Scholar 

  • Blackman, J.G., Ginsborg, B.L., Ray, C.: Synaptic transmission in the sympathetic ganglion of the frog. J. Physiol. (Lond.) 167, 355–373 (1963)

    CAS  Google Scholar 

  • Branisteanu, D.D., Volle, R.L.: Modification by lithium of transmitter release at the neuromuscular junction of the frog. J. Pharmacol. Exp. Ther. 194, 362–372 (1975)

    PubMed  CAS  Google Scholar 

  • Branisteanu, D.D., Miyamoto, M.D., Volle, R.L.: Quantal release parameters during fade of end plate potentials. Naunyn Schmiedebergs Arch. Pharmacol. 288, 323–327 (1975)

    Article  CAS  Google Scholar 

  • Brown, D.A.: Depolarisation of normal and preganglionically denervated superior cervical ganglia by stimulant drugs. Br. J. Pharmacol. 26, 511–520 (1966)

    CAS  Google Scholar 

  • Brown, D.A.: Responses of normal and denervated cat superior cervical ganglia to some stimulant compounds. J. Physiol (Lond.) 201, 225–236 (1969)

    CAS  Google Scholar 

  • Brown, D.A., Scholfield, C.N.: Movements of labelled sodium ions in isolated rat superior cervical ganglia. J. Physiol. (Lond.) 242, 321–351 (1974a)

    CAS  Google Scholar 

  • Brown, D.A., Scholfield, C.N.: Changes of intracellular sodium and potassium ion concentrations in isolated rat superior cervical ganglia induced by depolarising agents. J. Physiol. (Lond.) 242, 307–319 (1974 b)

    CAS  Google Scholar 

  • Brown, D.A., Jones, K.B., Halliwell, J.V., Quilliam, J.P.: Evidence against a presynaptic action of acetylcholine during ganglionic transmission. Nature (Lond.) 226, 958–959 (1970)

    Article  CAS  Google Scholar 

  • Brown, D.A., Brownstein, M.J., Scholfield, C.N.: Origin of the after-hyperpolarisation that follows removal of depolarising agents from the isolated superior cervical ganglion of the rat. Br. J. Pharmacol. 44, 651–670 (1972)

    PubMed  CAS  Google Scholar 

  • Burn, J.H., Rand, M.J.: Acetylcholine in adrenergic transmission. Annu. Rev. Pharmacol. 5, 163–182 (1965)

    Article  CAS  Google Scholar 

  • Ciani, S., Edwards, C.: The effect of acetylcholine on neuromuscular transmission in the frog. J. Pharmacol. Exp. Ther. 142, 21–23 (1963)

    PubMed  CAS  Google Scholar 

  • Collier, B., Katz, H.S.: The release of acetylcholine by acetylcholine in the cat’s superior cervical ganglion. Br. J. Pharmacol. 39, 428–438 (1970)

    PubMed  CAS  Google Scholar 

  • Collier, B., Katz, H.S.: The synthesis, turnover, and release of surplus acetylcholine in a sympathetic ganglion. J. Physiol. (Lond.) 214, 537–552 (1971)

    CAS  Google Scholar 

  • Collier, B., Katz, H.S.: Studies upon the mechanism by which acetylcholine releases surplus acetylcholine in a sympathetic ganglion. Br. J. Pharmacol. 55, 189–197 (1975)

    PubMed  CAS  Google Scholar 

  • Colquhoun, D., Dionne, V.E., Steinbach, J.H., Stevens, C.F.: Conductance of channels opened by acetylcholine-like drugs in muscle end plate. Nature (Lond.) 253, 204–206 (1975)

    Article  CAS  Google Scholar 

  • DeGroat, W.C., Voile, R.L.: Ganglionic actions of oxotremorine. Life Sci. 8, 618–623 (1963)

    Article  PubMed  CAS  Google Scholar 

  • Dennis, M.J., Harris, A.J., Kuffler, S.W.: Synaptic transmission and its duplication by locally applied acetylcholine in parasympathetic neurons in the heart of the frog. Proc. R. Soc. London [Biol.] 177, 509–539 (1971)

    Article  CAS  Google Scholar 

  • Dudel, J.: The effect of polarising current on action potential and transmitter release in crayfish motor nerve terminals. Pflügers Arch. 324, 227–248 (1971)

    Article  PubMed  CAS  Google Scholar 

  • Dun, N., Nishi, S.: Electrophysiological investigations of the denervated sympathetic ganglion. Fed. Proc. 33, 299 (1974)

    Google Scholar 

  • Dunant, Y.: Some properties of the presynaptic nerve terminals in a mammalian sympathetic ganglion. J. Physiol. (Lond.) 221, 577–587 (1972)

    CAS  Google Scholar 

  • Eccles, J.C.: The physiology of synapses, p. 130. New York: Springer 1964

    Book  Google Scholar 

  • Eccles, R.M.: Intracellular potentials recorded from a mammalian sympathetic ganglion. J. Physiol. (Lond.) 130, 572–584 (1955)

    CAS  Google Scholar 

  • Eccles, R.M.: The effect of nicotine on synaptic transmission in the sympathetic ganglion. J. Pharmacol. Exp. Ther. 118, 26–38 (1956)

    PubMed  CAS  Google Scholar 

  • Edwards, C., Ikeda, K.: Effects of 2-PAM and succinylcholine on neuromuscular transmission in the frog. J. Pharmacol. Exp. Ther. 138, 322–328 (1962)

    CAS  Google Scholar 

  • Ferry, C.B.: The sympathomimetic effect of acetylcholine on the spleen of the cat. J. Physiol. (Lond.) 161, 487–504 (1963)

    Google Scholar 

  • Gebber, G.L.: Dissociation of depolarisation and ganglionic blockade induced by nicotine. J. Pharmacol. Exp. Ther. 160, 124–134 (1968)

    PubMed  CAS  Google Scholar 

  • Gebber, G.L., Volle, R.L.: Ganglionic stimulating properties of aliphatic esters of choline and thiocholine. J. Pharmacol. Exp. Ther. 150, 67–74 (1965)

    PubMed  CAS  Google Scholar 

  • Gebber, G.L., Volle, R.L.: Mechanisms involved in ganglionic blockade induced by tetramethyl-ammonium. J. Pharmacol. Exp. Ther. 152, 18–28 (1966)

    PubMed  CAS  Google Scholar 

  • Gebber, G.L., Snyder, D.W.: Observations on drug-induced activation of cholinoceptive sites in a sympathetic ganglion. J. Pharmacol. Exp. Ther. 163, 64–74 (1968)

    PubMed  CAS  Google Scholar 

  • Ginetzinsky, A.G., Shamarina, N.M.: The tonomotor phenomenon in denervated muscle. Usp. Sovrem. Biol. 15, 283–294 (1942) (Russ.)

    Google Scholar 

  • Ginsborg, B.L.: The actions of McN-A-343, pilocarpine and acetyl- β-methylcholine on sympathetic ganglion cells of the frog. J. Pharmacol. Exp. Ther. 150, 216–219 (1965)

    PubMed  CAS  Google Scholar 

  • Ginsborg, B.L.: On the presynaptic acetylcholine receptors in sympathetic ganglia of the frog. J. Physiol. (Lond.) 216, 237–246 (1971)

    CAS  Google Scholar 

  • Ginsborg, B.L., Guerrero, S.: On the action of depolarising drugs on sympathetic ganglion cells of the frog. J. Physiol. (Lond.) 172, 189–206 (1964)

    CAS  Google Scholar 

  • Green III, R.D.: The effect of denervation on the sensitivity of the superior cervical ganglion of the pithed cat. J. Pharmacol. Exp. Ther. 167, 143–150 (1969)

    PubMed  CAS  Google Scholar 

  • Gumulka, W., Szreniawski, Z.: The effect of 1,1 -dimethyl-4-phenylpiperazinium iodide on transmission in the superior cervical ganglion of the cat. Int. J. Neuropharmacol. 7, 511–515 (1968)

    Article  PubMed  CAS  Google Scholar 

  • Gyermek, L.: Ganglionic stimulant and depressant agents. In: Drugs affecting the peripheral nervous system. Burger, A. (ed.), Vol.I, pp. 149–326. New York: Marcel Dekker 1967

    Google Scholar 

  • Haefely, W.: Electrophysiology of the adrenergic neuron. In: Catecholamines. Blaschko, H., Muscholl, E. (eds.), pp. 661–725. Berlin, Heidelberg, New York: Springer 1972

    Google Scholar 

  • Haefely, W.: The effects of 1,1 -dimethyl-4-phenyl-piperazinium (DMPP) in the cat superior cervical ganglion in situ. Naunyn Schmiedebergs Arch. Pharmacol. 281, 57–91 (1974 a)

    Article  CAS  Google Scholar 

  • Haefely, W.: The effects of various “nicotine-like” agents in the cat superior cervical ganglion in situ. Naunyn Schmiedebergs Arch. Pharmacol. 281, 93–117 (1974 b)

    Article  PubMed  CAS  Google Scholar 

  • Hamilton, J.T., Rubinstein, H.M.: Nicotinic and muscarinic activity of benzyl trime-thylammonium and its α-,β-, and γ-substituted pyridylmethyltrimethylammonium analogs. J. Pharmacol. Exp. Ther. 160, 112–123 (1968)

    PubMed  CAS  Google Scholar 

  • Hancock, J.C., Henderson, E.G.: Antinicotinic action of nicotine and lobeline on frog sartorius muscle. Naunyn Schmiedebergs Arch. Pharmacol. 272, 307–324 (1972)

    Article  CAS  Google Scholar 

  • Hancock, J.C., Volle, R.L.: Blockade of conduction in vagal fibres by nicotinic drugs. Arch. Int. Pharmacodyn. 178, 85–98 (1969 a)

    PubMed  CAS  Google Scholar 

  • Hancock, J.C., Volle, R.L.: Enhancement by cesium ions of ganglionic hyperpolarisation induced by dimethylphenylpiperazinium (DMPP) and repetitive preganglionic stimulation. J. Pharmacol. Exp. Ther. 169, 201–210 (1969 b)

    PubMed  CAS  Google Scholar 

  • Hancock, J.C., Volle, R.L.: Cholinoceptive sites in the rat superior cervical ganglion. Arch. Int. Pharmacodyn. 184, 111–120 (1970 a)

    PubMed  CAS  Google Scholar 

  • Hancock, J.C., Volle, R.L.: Stimulation by carbachol and tetramethylammonium ions of intact and denervated sympathetic ganglia. Life Sci. 9, 301–308 (1970 b)

    Article  PubMed  CAS  Google Scholar 

  • Henderson, E.G., Hancock, J.C.: Nicotine-induced depolarisation and stimulation of potassium efflux in striated muscle. J. Pharmacol. Exp. Ther. 177, 377–388 (1971)

    PubMed  CAS  Google Scholar 

  • Hodgkin, A.L., Katz, B.: The effect of sodium ions on the electrical activity of the giant axon of the squid. J. Physiol. (Lond.) 108, 37–77 (1949)

    CAS  Google Scholar 

  • Hubbard, J.I., Willis, W.D.: The effects of depolarisation of motor nerve terminals upon the release of transmitter by nerve impulses. J. Physiol. (Lond.) 194, 381–405 (1968)

    CAS  Google Scholar 

  • Hubbard, J.I., Schmidt, R.F., Yokota, T.: The effect of acetylcholine upon mammalian motor nerve terminals. J. Physiol. (Lond.) 181, 810–829 (1965)

    CAS  Google Scholar 

  • Hubbard, J.I., Llinás, R., Quastel, D.M.J.: Electrophysiological analysis of synaptic transmission. Baltimore: Williams and Wilkens 1969

    Google Scholar 

  • Jaramillo, J.: Ganglionic actions of α,α’-bis-(dimethylammoniumacetylaldehyde diethylacetal)-p- p’-diacetylbiphenyl dibromide (DMAE). J. Pharmacol. Exp. Ther. 162, 30–37 (1968)

    PubMed  CAS  Google Scholar 

  • Jaramillo, J., Volle, R.L.: Ganglion blockade by muscarine, oxotremorine and AHR-602. J. Pharmacol. Exp. Ther. 158, 80–88 (1967 a)

    PubMed  CAS  Google Scholar 

  • Jaramillo, J., Volle, R.L.: Nonmuscarinic stimulation and block of a sympathetic ganglion by 4-(m-chlorophenylcarbamoyloxy)-2-butyryltrimethylammonium chloride (McN-A-343). J. Pharmacol. Exp. Ther. 157, 337–345 (1967b)

    PubMed  CAS  Google Scholar 

  • Jaramillo, J., Volle, R.L.: A comparison of the ganglionic stimulating and blocking properties of some nicotinic drugs. Arch. Int. Pharmacodyn. 174, 88–97 (1968 a)

    PubMed  CAS  Google Scholar 

  • Jaramillo, J., Volle, R.L.: Effects of lithium on ganglionic hyperpolarisation and blockade by dimethylphenylpiperazinium. J. Pharmacol. Exp. Ther. 164, 166–175 (1968 b)

    PubMed  CAS  Google Scholar 

  • Katz, B.: The transmission of impulses from nerve to muscle, and the cellular unit of synaptic action. Proc. R. Soc. Lond. [Biol] 155, 455–477 (1962)

    Article  Google Scholar 

  • Katz, B.: The release of neural transmitter substances. Liverpool: University Press 1969

    Google Scholar 

  • Katz, B., Miledi, R.: Further observations on acetylcholine noise. Nature (Lond.) 232, 124–126 (1971)

    Article  CAS  Google Scholar 

  • Katz, B., Miledi, R.: The statistical nature of the acetylcholine potential and its molecular components. J. Physiol. (Lond.) 224, 665–699 (1972)

    CAS  Google Scholar 

  • Katz, B., Thesleff, S.: A study of the “desensitisation” produced by acetylcholine at the motor end plate. J. Physiol (Lond.) 138, 63–80 (1957)

    CAS  Google Scholar 

  • Kelly, J.S.: The antagonism of Ca2+ by Na+ and other monovalent ions at the frog neuromuscular junction. Q. J. Exp. Physiol. 53, 239–249 (1968)

    CAS  Google Scholar 

  • Keynes, R.D., Swan, R.C.: The permeability of frog muscle fibres to lithium ions. J. Physiol. (Lond.) 147, 626–638 (1959)

    CAS  Google Scholar 

  • Kharkevich, D.A.: Ganglionic agents. Moskva: Medgiz 1962 (Russ.)

    Google Scholar 

  • Kharkevich, D.A.: Ganglion-blocking and ganglion-stimulating agents. Oxford: Pergamon Press 1967 (translated from Russian edition, 1962)

    Google Scholar 

  • Klingman, J.D.: Effects of lithium ions on the rat superior cervical ganglion. Life Sci. 5, 365–373 (1966)

    Article  PubMed  CAS  Google Scholar 

  • Koketsu, K.: Cholinergic synaptic potentials and the underlying ionic mechanisms. Fed. Proc. 28, 101–112(1969)

    PubMed  CAS  Google Scholar 

  • Koketsu, K., Nishi, S.: Cholinergic receptors at sympathetic preganglionic nerve terminals. J. Physiol. (Lond.) 196, 293–310 (1968 a)

    CAS  Google Scholar 

  • Koketsu, K., Nishi, S., Soeda, H.: Calcium and acetylcholine-potential of bullfrog sympathetic ganglion cell membrane. Life Sci. 7, Part I, 955–963 (1968 b)

    Article  PubMed  CAS  Google Scholar 

  • Kosterlitz, H.W., Lees, G.M.: Interrelationships between adrenergic and cholinergic mechanisms. In: Catecholamines. Blaschko, H., Muscholl, E. (eds.). Berlin, Heidelberg, New York: Springer 1972

    Google Scholar 

  • Kosterlitz, H.W., Lees, G.M., Wallis, D.I.: Resting and action potentials recorded by the sucrose-gap method in the superior cervical ganglion of the rabbit. J. Physiol. (Lond.) 195, 39–53 (1968)

    CAS  Google Scholar 

  • Kosterlitz, H.W., Lees, G.M., Wallis, D.I.: Further evidence for an electrogenic pump in a mammalian sympathetic ganglion. Br. J. Pharmacol. 38, 464–465 P (1970)

    Google Scholar 

  • Kristic, M.K.: The action of choline on the superior cervical ganglion of the cat. Eur. J. Pharmacol. 17, 87–96(1972)

    Article  Google Scholar 

  • Kuffler, S.W., Dennis, M.J., Harris, A.J.: The development of chemosensitivity in extrasynaptic areas of the neuronal surface after denervation of parasympathetic ganglion cells in the heart of the frog. Proc. R. Soc. Lond. [Biol] 177, 555–563 (1971)

    Article  CAS  Google Scholar 

  • Lukomskaya, N.Ya.: Change in cholinergic sensitivity after denervation of the superior cervical ganglion of the cat. Zh. Evol. Biokhim. Fiziol. 5, 65–73 (1969) (Russ.)

    CAS  Google Scholar 

  • Lundberg, A., Thesleff, S.: Dual action of nicotine on the sympathetic ganglion of the cat. Acta Physiol. Scand. 28, 218–223 (1953)

    Article  PubMed  CAS  Google Scholar 

  • Machovä, J., Boskä, D.: The effect of 5-hydroxytryptamine, dimethylphenylpiperazinium and acetylcholine on transmission and surface potential in the cat sympathetic ganglion. Eur. J. Pharmacol. 7, 152–158 (1969)

    Article  PubMed  Google Scholar 

  • Magazanik, L.G.: Mechanism of desensitisation of the postsynaptic membrane of the muscle membrane. Biofizika 13, 199–214 (1969) (Russ.)

    Google Scholar 

  • Martin, A.R., Pilar, G.: Quantal components of the synaptic potential in the ciliary ganglion of the chick. J. Physiol. (Lond.) 175, 1–16 (1964)

    CAS  Google Scholar 

  • Matthews, E.K.: The presynaptic effects of quaternary ammonium compounds on the acetylcholine metabolism of a sympathetic ganglion. Br. J. Pharmacol. Chemother. 26, 552–566 (1966)

    PubMed  CAS  Google Scholar 

  • McKinstry, D.N., Koelle, G.B.: Acetylcholine release from the cat superior cervical ganglion by carbachol. J. Pharmacol. Exp. Ther. 157, 319–327 (1967)

    PubMed  CAS  Google Scholar 

  • McKinstry, D.N., Koenig, E., Koelle, W.A., Koelle, G.B.: The release of acetylcholine from a sympathetic ganglion by carbachol. Relationship to the functional significance of the localisation of acetylcholinesterase. Can. J. Biochem. Physiol. 41, 2599–2609 (1963)

    Article  PubMed  CAS  Google Scholar 

  • Miledi, R.: The acetylcholine sensitivity of frog muscle fibres after complete or partial denervation. J. Physiol. (Lond.) 151, 1–23 (1960)

    CAS  Google Scholar 

  • Miyamoto, M.D., Volle, R.L.: Enhancement by carbachol of transmitter release from motor nerve terminals. Proc. Natl. Acad. Sci. USA 71, 1489–1492 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Nishi, S.: The cholinergic and adrenergic receptors of presynaptic nerves of sympathetic ganglia. Fed. Proc. 29, 1956–1965 (1970)

    Google Scholar 

  • Nishi, S., Koketsu, K.: Electrical properties and activities of single sympathetic neurones in frogs. J. Cell. Comp. Physiol 55, 15–30 (1960)

    Article  PubMed  CAS  Google Scholar 

  • Nishi, S., Soeda, H., Koketsu, K.: Influence of membrane potential on the fast-acetylcholine potential of sympathetic ganglion cells. Life Sci. 8, Part I, 499–505 (1969)

    Article  PubMed  CAS  Google Scholar 

  • Onodera, K., Yamakawa, K.: The effects of lithium on the neuromuscular junction of the frog. Jpn. J. Physiol 16, 541–550 (1966)

    Article  PubMed  CAS  Google Scholar 

  • Pappano, A.J., Volle, R.L.: Observations on the role of calcium ions in ganglionic responses to acetylcholine. J. Pharmacol Exp. Ther. 152, 171–180 (1966)

    PubMed  CAS  Google Scholar 

  • Pappano, A.J., Volle, R.L.: Actions of lithium ions in mammalian sympathetic ganglia. J. Pharmacol Exp. Ther. 157, 346–355 (1967)

    PubMed  CAS  Google Scholar 

  • Pascoe, J.E.: The effects of acetylcholine and other drugs on the isolated superior cervical ganglion. J. Physiol (Lond.) 132, 242–255 (1956)

    CAS  Google Scholar 

  • Paton, W.D.M., Perry, W.L.M.: The relationship between depolarisation and block in the cat’s superior cervical ganglion. J. Physiol (Lond.) 119, 43–57 (1953)

    CAS  Google Scholar 

  • Perry, W.L.M., Reinert, H.: The effects of preganglionic denervation on the reactions of ganglion cells. J. Physiol (Lond.) 126, 101–115 (1954)

    CAS  Google Scholar 

  • Pilar, G.: The physiology of preganglionic terminals. NATO Advanced Study Institute 46–61 (1969)

    Google Scholar 

  • Rang, H.P., Ritchie, J.M.: On the electrogenic sodium pump in mammalian non myelinated nerve fibres and its activation by various external cations. J. Physiol (Lond.) 196, 183–221 (1968)

    CAS  Google Scholar 

  • Rang, H.P., Ritter, J.M.: A new kind of drug antagonism: Evidence that agonists cause a molecular change in acetylcholine receptors. Mol Pharmacol 5, 394–411 (1969)

    PubMed  CAS  Google Scholar 

  • Riker, W.K.: The basis of the low-amplitude discharge produced by acetylcholine injections in sympathetic ganglia. J. Pharmacol. Exp. Ther. 155, 203–210 (1967)

    PubMed  CAS  Google Scholar 

  • Riker, W.K.: Ganglion cell depolarisation and transmission block by ACh: independent events. J. Pharmacol Exp. Ther. 159, 345–352 (1968)

    PubMed  CAS  Google Scholar 

  • Riker, W.F. Jr, Standaert, F.G.: The action of facilitatory drugs and acetylcholine on neuromuscular transmission. Ann. N.Y. Acad. Sci. 135, 163–176 (1966)

    Article  PubMed  Google Scholar 

  • Ritchie, J.M., Straub, R.: The hyperpolarisation which follows activity in mammalian nonmedul-lated fibres. J. Physiol. (Lond.) 136, 80–97 (1957)

    CAS  Google Scholar 

  • Roszkowski, A.P.: An unusual type of sympathetic ganglionic stimulant. J. Pharmacol. Exp. Ther. 132, 156–170 (1961)

    PubMed  CAS  Google Scholar 

  • Sjodin, R.A., Beauge, L.A.: Coupling and selectivity of sodium and potassium transport in squid giant axons. J. Gen. Physiol 51, 152–161 S (1968)

    PubMed  CAS  Google Scholar 

  • Steinberg, M.I., Volle, R.L.: A comparison of lobeline and nicotine at the frog neuromuscular junction. Naunyn Schmiedebergs Arch. Pharmacol. 272, 16–31 (1972)

    Article  CAS  Google Scholar 

  • Takeshige, C., Volle, R.L.: Bimodal response of sympathetic ganglia to acetylcholine following eserine or repetitive preganglionic stimulation. J. Pharmacol. Exp. Ther. 138, 66–73 (1962)

    PubMed  CAS  Google Scholar 

  • Takeshige, C., Volle, R.L.: Cholinoceptive sites in denervated sympathetic ganglia. J. Pharmacol. Exp. Ther. 141, 206–213 (1963a)

    PubMed  CAS  Google Scholar 

  • Takeshige, C., Volle, R.L.: Asynchronous postganglionic firing from the cat superior cervical sympathetic ganglion treated with neostigmine. Br. J. Pharmacol. 20, 214–220 (1963 b)

    CAS  Google Scholar 

  • Takeshige, C., Volle, R.L.: Similarities in the ganglionic actions of calcium ions and atropine. J. Pharmacol Exp. Ther. 145, 173–180 (1964a)

    PubMed  CAS  Google Scholar 

  • Takeshige, C., Volle, R.L.: The effects of barium and other inorganic cations on sympathetic ganglia. J. Pharmacol Exp. Ther. 146, 327–334 (1964b)

    PubMed  CAS  Google Scholar 

  • Takeshige, C., Volle, R.L.: Modification of ganglionic responses to cholinomimetic drugs following preganglionic stimulation, anticholinesterase agents and pilocarpine. J. Pharmacol Exp. Ther. 146, 335–343 (1964c)

    PubMed  CAS  Google Scholar 

  • Takeshige, C., Pappano, A.J., DeGroat, W.C., Volle, R.L.: Ganglionic blockade produced in sympathetic ganglia by cholinomimetic drugs. J. Pharmacol. Exp. Ther. 141, 333–342 (1963)

    PubMed  CAS  Google Scholar 

  • Takeuchi, A., Takeuchi, N.: Changes in potassium concentration around motor nerve terminals, produced by current flow, and their effects on neuromuscular transmission. J. Physiol (Lond.) 155, 46–58 (1961)

    CAS  Google Scholar 

  • Takeuchi, A., Takeuchi, N.: Electrical changes in pre- and postsynaptic axons of the giant synapse of Loligo. J. Gen. Physiol 45, 1181–1193 (1962)

    Article  PubMed  CAS  Google Scholar 

  • Tauc, L.: Transmission in invertebrate and vertebrate ganglia. Physiol. Rev. 47, 521–593 (1967)

    PubMed  CAS  Google Scholar 

  • Thesleff, S.: The mode of neuromuscular block caused by acetylcholine, nicotine, decamethonium, and succinylcholine. Acta Physiol. Scand. 34, 218–231 (1955)

    Article  CAS  Google Scholar 

  • Trendelenburg, U.: Non-nicotinic ganglion-stimulating substances. Fed. Proc. 18, 1001–1005 (1959)

    PubMed  CAS  Google Scholar 

  • Trendelenburg, U.: Some aspects of the pharmacology of autonomic ganglion cells. Ergeb. Physiol. 59, 1–85 (1967)

    Google Scholar 

  • Vickerson, F.H.L., Varma, D.R.: Effects of denervation on the sensitivity of the superior cervical ganglion of the cat to acetylcholine and McN-A-343. Can. J. Biochem. Physiol. 47, 255–259 (1969)

    CAS  Google Scholar 

  • Vladimirova, I.A.: The effect of electrical polarisation of the motor nerve endings on the transmission through them of single impulses. Bull. Exp. Biol. Med. 56, 1180–1183 (1963) (Russ.)

    Article  Google Scholar 

  • Volle, R.L.: Enhancement of postganglionic responses to stimulating agents following repetitive preganglionic stimulation. J. Pharmacol. Exp. Ther. 136, 68–74 (1962)

    PubMed  CAS  Google Scholar 

  • Volle, R.L.: Muscarinic and nicotinic stimulant actions at autonomic ganglia. International encylopedia of pharmacology and therapeutics, Sect. 12, Voll. London: Pergamon Press 1966 a

    Google Scholar 

  • Volle, R.L.: Modification by drugs of synaptic mechanisms in autonomic ganglia. Pharmacol. Rev. 18, 839–869 (1966 b)

    CAS  Google Scholar 

  • Volle, R.L.: Frequency dependent decrease of quantal content in a drug-treated neuromuscular junction. Naunyn Schmidebergs Arch. Pharmacol. 278, 271–284 (1973)

    Article  CAS  Google Scholar 

  • Volle, R.L.: Blockade by lobeline of potassium exchange in skeletal muscle. Relationship to receptor desensitisation at the end plate. Naunyn Schmiedebergs Arch. Pharmacol. 282, 335–347 (1974)

    Article  CAS  Google Scholar 

  • Volle, R.L.: Cellular pharmacology of autonomic ganglia. In: Cellular pharmacology of excitable tissues. Narahashi, T. (ed.), pp. 89–140. Springfield: Charles C. Thomas 1975

    Google Scholar 

  • Volle, R.L., Henderson, E.G.: Pre- and postjunctional neuromuscular blockade by carbachol. Naunyn Schmiedebergs Arch. Pharmacol. 291, 4, 359–370 (1975)

    Article  CAS  Google Scholar 

  • Volle, R.L., Koelle, G.B.: The physiological role of acetylcholinesterase in sympathetic ganglia. J. Pharmacoe. Exp. Ther. 129, 223–240 (1961)

    Google Scholar 

  • Volle, R.L., Koelle, G.B.: Ganglionic stimulating and blocking agents. In: The pharmacological basis of therapeutics, 5 th ed., Goodman, L.S., Gilman, A., (eds.), pp. 565–574. New York: Macmillan 1975

    Google Scholar 

  • Wang, C.M., Narahashi, T.: Mechanisms of dual action of nicotine on end plate membranes. J. Pharmacol. Exp. Ther. 182, 427–441 (1972)

    PubMed  CAS  Google Scholar 

  • Wong, S., Long, J.P.: Potentiation of action of catecholamines by a derivative of hemicholinium. J. Pharmacol. Exp. Ther. 156, 469–482 (1967)

    PubMed  CAS  Google Scholar 

  • Wong, S., Long, J.P.: Antagonism of ganglionic stimulants by α, α’-bis-(dimethylammoni-umacetaldehyde diethylacetal)-p-p’-diacetylbiphenyl bromide (DMAE). J. Pharmacol. Exp. Ther. 164, 176–184 (1968)

    PubMed  CAS  Google Scholar 

  • Woodward, J.K., Bianchi, C.P., Erulkar, S.D.: Electrolyte distribution in rabbit superior cervical ganglion. J. Neurochem. 16, 289–299 (1969)

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. R. L. Volle
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Pharmacology, First Medical Institute, 2/6, B. Pirogovskaja St., 119435, Moscow, USSR

    Dimitry A. Kharkevich

Rights and permissions

Reprints and permissions

Copyright information

© 1980 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Volle, R.L. (1980). Nicotinic Ganglion-Stimulating Agents. In: Kharkevich, D.A. (eds) Pharmacology of Ganglionic Transmission. Handbook of Experimental Pharmacology, vol 53. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67397-9_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-67397-9_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-67399-3

  • Online ISBN: 978-3-642-67397-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation