Summary
An analog of hemicholinium-3 caused the fade of endplate potentials during repetitive stimulation at low rates. The quantal parameters of release were estimated during steady-state conditions before and in the presence of the drug. The fade of EPP's was associated with a decrease in quantal content (m). The decrease in m was, in turn, associated with a decrease in the binomial parameter n and an increase in the binomial parameter p. The changes in n and p are discussed in relation to available stores of transmitter and the probability of transmitter release.
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Supported by grant NS-07540-08, Institute of Neurological Diseases and Stroke, N.I.H., U.S.P.H.S.
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Branisteanu, D.D., Miyamoto, M.D. & Volle, R.L. Quantal release parameters during fade of endplate potentials. Naunyn-Schmiedeberg's Arch. Pharmacol. 288, 323–327 (1975). https://doi.org/10.1007/BF00500538
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DOI: https://doi.org/10.1007/BF00500538