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Laparoscopy and Immunology

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Minimally Invasive Surgical Oncology

Abstract

Surgery has long been known to cause transient suppression of the immune system. The arrival of minimally invasive surgery brought about a new interest in the immunologic effects of both open and laparoscopic methods. This chapter includes a literature review of surgery’s effect on known components of the immune system such as C-reactive protein (CRP), Interleukin (IL)-6, Tumor Necrosis Factor (TNF)-a, IL-1, Delayed-type Hypersensitivity (DTH) (T-Cell function), systemic monocyte function, Natural Killer Cell Activity, Lymphocytes, and Peritoneal Immunity. Also covered are the investigations into the impact of anesthesia, pneumoperitoneum, and surgery on the immune system including tumor resistance and angiogenesis-related protein changes. Generally, laparoscopic procedures are associated with less severe and, usually, shorter duration alterations than laparotomy and open surgical procedures.

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  1. Department of Surgery, St. Luke’s Roosevelt Hospital, 425 West 59th Street, St. Luke’s Roosevelt Hospital Suite 7B, New York, NY, 10019, USA

    Michael J. Grieco & Richard Larry Whelan

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  1. Michael J. Grieco
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  2. Richard Larry Whelan
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Correspondence to Richard Larry Whelan .

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  1. Surgical Oncologist/Minimally Invasive S, Osborn Street 263, Philadelphia, 19128, Pennsylvania, USA

    Ronald Matteotti

  2. Chief, General Surgery, Department of Surgery, Brigham and Women's Hospital/Harvard Med, Francis St. 75, Boston, 02115, Massachusetts, USA

    Stanley W. Ashley

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Grieco, M.J., Whelan, R.L. (2011). Laparoscopy and Immunology. In: Matteotti, R., Ashley, S. (eds) Minimally Invasive Surgical Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-45021-4_7

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