Skip to main content
SpringerLink
Log in

Interleukin-6 and coagulation-fibrinolysis fluctuations after laparoscopic and conventional cholecystectomy

  • Original Articles
  • Published:
Surgical Endoscopy Aims and scope Submit manuscript

Abstract

This study assesses quantitatively the fluctuations of interleukin-6 (IL-6) and coagulationfibrinolysis proteins in patients undergoing elective laparoscopic (n=14) and conventional (n=10) cholecystectomy. The patients in both groups were comparable in age and sex. Serum levels of interleukin-6, and plasma levels of fibrinogen, von Willebrand factor-antigen, tissue-type plasminogen activator-antigen, and plasminogen activator inhibitor-1 were determined for up to 48 h postoperatively. The postoperative changes of all parameters tested were comparable in both patient groups with a trend toward a higher interleukin-6 response at 8 h postincision (NS) and a trend toward a higher fibrinolysis inhibition (NS) after conventional cholecystectomy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Baigrie RJ, Lamont P, Kwiathkowski D, Dallman M, Morris P (1992) Systemic cytokine response after major surgery. Br J Surg 79: 757–760

    Google Scholar 

  2. Calandra T, Gerain J, Heumann D, Baumgartner J-D, Glauser M (1991) High circulating levels of interleukin-6 in patients with septic shock: evolution during sepsis, prognostic value, and interplay with other cytokines. Am J Med 91: 23–29

    Google Scholar 

  3. Chakrabarti R, Hocking ED, Fearnley GR (1969) Reaction pattern to three stresses—electroplexy, surgery and myocardial infarction—of fibrinolysis and plasma fibrinogen. J Clin Pathol 22: 659–662

    Google Scholar 

  4. Chambers LM, Tompkins RG, Burke JF (1991) Response to trauma. In: Pollock A (ed) Immunology in surgical practice, chapter 4. Edward Arnold, London, pp 40–69

    Google Scholar 

  5. Collins GJ, Barber JA, Zajtchukr R, (1977) The effects of operative stress on the coagulation profile. Am J Surg 133: 612

    Google Scholar 

  6. Cruickshank A, Fraser W, Burns H, Van Damme J, Shenkin A (1990) Response of serum interleukin-6 in patients undergoing elective surgery of varying severity. Clin Sci 79: 57(1–5)

    Google Scholar 

  7. Cuschieri A, Dubois F, Mouiel J, Mouret P (1991) The European experience with laparoscopic cholecystectomy. Am J Surg 161:385–387

    Google Scholar 

  8. Declerck P, Aless MC, Verstreken K, Kruithof E, Juhan-Vague I, Collen D (1988) Measurement of plasminogen activator inhibitor-1 in biological fluids with a mucine monoclonal-based enzyme-linked immunosorbent assay. Blood 71: 220–225

    Google Scholar 

  9. Di Padova F, Pozzi C, Tondre MJ, Tritapepe R (1991) Selective and early increase of IL-1 inhibitors, IL-6 and cortisol after elective surgery. Clin Exp Immunol 85: 137–142

    Google Scholar 

  10. Fischer C, Gill C, Forrester M, Nakamura R (1976) Quantitation of ‘acute-phase proteins’ postoperatively. Value in detection and monitoring of complications. Am J Clin Pathol 66: 840–846

    Google Scholar 

  11. Gordon-Smith DC, Hickman JA, Le Quesne LP (1974) Postoperative fibrinolytic activity and deep vein thrombosis. Br J Surg 61: 213–218

    Google Scholar 

  12. Griffiths NJ, Woodford M, Irving MH (1977) Alteration in fibrinolytic capacity after operation. Lancet ii: 635–637

    Google Scholar 

  13. Hoffmann J, Verhappen M (1988) Automated nephelometry of fibrinogen: analytical performance and observations during thrombolytic therapy. Clin Chem 34: 2135–2140

    Google Scholar 

  14. Holvoet P, Cleemput H, Collen D (1985) Assay of human tissue-type plasminogen activator (t-PA) with an enzyme-linked immunosorbent assay (ELISA) based on three mucine monoclonal antibodies to t-PA. Thromb Haemost 54: 684–687

    Google Scholar 

  15. Kluft C, Verheijen JH, Jie AFH, Rijken DC, Preston FE, SueLing HM, Jespersen J, Aasen AO (1985) The postoperative fibrinolytic shutdown: a rapidly reverting acute phase pattern for the fast-acting inhibitor of tissue-type plasminogen activator after trauma. Scan J Clin Lab Invest 45: 605–610

    Google Scholar 

  16. MacIntyre IMC, Webber RG, Crispin JR, Jones DRB, Wood JK, Allan NC, Prescott RJ, Ruckley CV (1976) Plasma fibrinolysis and postoperative deep vein thrombosis. Br J Surg 63: 694–697

    Google Scholar 

  17. Mealy K, Gallagher H, Barry M, Lennon F, Traynor O, Hyland J (1992) Physiological and metabolic responses to open and laparoscopic cholecystectomy. Br J Surg 79: 1061–1064

    Google Scholar 

  18. Molloy RG, Mannick J, Rodrick M (1993) Cytokines, sepsis and immunomodulation. Br J Surg 80: 289–297

    Google Scholar 

  19. Nijsten M, Degroot E, Tenduis H, Klasen H, Hack C, Aarden L (1987) Serum levels of interleukin-6 and acute phase responses. Lancet 2: 921

    Google Scholar 

  20. Peters JH, Ellison EC, Innes JT, Liss JL, Nichols KE, Lomano JM, Roby SR, Front ME, Carey LC (1991) Safety and efficacy of laparoscopic cholecystectomy. A prospective analysis of 100 initial patients. Ann Surg 213: 3–12

    Google Scholar 

  21. Roitt I (1991) The acquired immune response. Production of effectors. In: Roitt I (ed), Essential immunology, 7th edition, chapter 7. Blackwell Scientific Publications, Oxford, pp 141–147

    Google Scholar 

  22. Roumen RM, Meurs PA, Kuypers H, Kraak WA, Sauerwein RW (1992) Serum interleukin-6 and C-reactive protein responses in patients after laparoscopic or conventional cholecystectomy. Eur J Surg 158: 541–544

    Google Scholar 

  23. Seyfer AE, Seaber A, Dombrose FA, Urbaniak JR (1981) Coagulation changes in elective surgery and trauma. Ann Surg 193: 210–213

    Google Scholar 

  24. Shenkin A, Fraser W, Series J, Winstanley F, McCartney A, Burns H, Van Damme J (1989) The serum interleukin-6 response to elective surgery. Lymphokine Res 8: 123–126

    Google Scholar 

  25. Shimomura K, Ohtomo Y, Ishizaki Y, Noie T, Abe H, Nayeem SA, Bandai Y, Idezuki Y (1992) Peripheral venous pressure analysis in the lower limb during pneumoperitoneum in clinical laparoscopic cholecystectomy. Surg Endosc 6: 87

    Google Scholar 

  26. Soper N, Barteau JA, Clayman RV, Ashley SW, Dunnegan DL (1992) Comparison of early postoperative results for laparoscopic versus standard open cholecystectomy. Surg Gynecol Obstet 174: 114–118

    Google Scholar 

  27. Tornai I, Declerck P, Smet L, Arnout J, Deckmyn H, Caekebeke-Peerlinck K, Vermylen J (1991) Measurement of von Willebrand factor-antigen in plasma and platelets with an enzyme-linked immunosorbent assay based on two mucine monoclonal antibodies. Haemostasis 21: 125–134

    Google Scholar 

  28. Van Snick J (1990) Interleukin-6: an overview. Annu Rev Immunol 8: 253–278

    Google Scholar 

  29. Vitale GC, Collet D, Larson GM, Cheadle WG, Miller FB, Perissat J (1991) Interruption of professional and home activity after laparoscopic cholecystectomy among French and American patients. Am J Surg 161: 396–398

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Abdominal Surgery, U.Z. Gasthuisberg, University of Leuven, Herestraat 49, 3000, Leuven, Belgium

    G. Vander Velpen, F. Penninckx & R. Kerremans

  2. Department of Virology and Rega Institute, U.Z. Gasthuisberg, University of Leuven, Herestraat 49, 3000, Leuven, Belgium

    J. Van Damme

  3. Department of Pathophysiology, U.Z. Gasthuisberg, University of Leuven, Herestraat 49, 3000, Leuven, Belgium

    J. Arnout

Authors
  1. G. Vander Velpen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. Penninckx
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. Kerremans
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. Van Damme
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J. Arnout
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vander Velpen, G., Penninckx, F., Kerremans, R. et al. Interleukin-6 and coagulation-fibrinolysis fluctuations after laparoscopic and conventional cholecystectomy. Surg Endosc 8, 1216–1220 (1994). https://doi.org/10.1007/BF00591054

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00591054

Key words

Search

Navigation