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BluePharmTrain: Biology and Biotechnology of Marine Sponges

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Grand Challenges in Marine Biotechnology

Part of the book series: Grand Challenges in Biology and Biotechnology ((GCBB))

Abstract

BluePharmTrain is a Marie Curie Initial Training Network of 17 European academic and industrial partners collaborating to train young scientists in multidisciplinary aspects of blue biotechnology. Harvesting marine sponges for the extraction of bioactive compounds is often highly unsustainable, and the chemical synthesis of promising compounds is often either too complex or very expensive. To find sustainable and economically feasible production methods of sponge-derived compounds, individual BluePharmTrain research projects explore innovative techniques, focusing on selected sponge species shown to harbour interesting active metabolites. The different techniques include sponge cell cultivation, cultivation of microbial symbionts, next-generation sequencing approaches (i.e. metagenomics and metatranscriptomics), in situ and ex situ cultivation of sponges, life cycle characterisation, chemical structure elucidation of compounds and compound metabolic pathway description. Altogether, these consorted efforts and collaborations lead to new insights on sponge metabolism, sponge-microbe interactions and bioactive compound production.

Authors “Georg Steinert” and “Carla Huete Stauffer” contributed equally to this work.

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Author information

Author notes

    Authors and Affiliations

    1. Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands

      Georg Steinert, Johanna Gutleben & Detmer Sipkema

    2. Marine Ecology Department, Centre d’Estudis Avançats de Blanes (CEAB), Consejo Superior de Investigaciones Científicas (CSIC), Blanes, Spain

      Carla Huete Stauffer

    3. Tallinn University of Technology, Tallinn, Estonia

      Nele Aas-Valleriani

    4. School of Microbiology, University College Cork, National University of Ireland, Cork, Ireland

      Erik Borchert

    5. Institute of Microbiology, Eidgenössische Technische Hochschule Zürich, Zürich, Switzerland

      Agneya Bhushan & Eike Edzard Peters

    6. School of Biosciences, Cardiff University, Cardiff, UK

      Alexandra Campbell

    7. Microbial Ecology Group, Genomic Research in Ecology and Evolution in Nature (GREEN), Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, Groningen, The Netherlands

      Maryam Chaib De Mares

    8. Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavík, Iceland

      Margarida Costa

    9. Department of Research and Innovation, Matis ohf., Reykjavik, Iceland

      Stephen Knobloch

    10. Birmingham Law School, University of Birmingham, Birmingham, UK

      Robert Gregory Lee & Ellen Stokes

    11. Division of Bioprocess Engineering, Wageningen University, Wageningen, The Netherlands

      Stephanie Munroe

    12. Harbor Branch Oceanographic Institute, Florida Atlantic University, Boca Raton, FL, USA

      Stephanie Munroe

    13. Department of Microbial Ecology and Diversity Research, Leibniz Institute DSMZ – German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany

      Deepak Naik

    14. Sustainable Place Research Institute, Cardiff University, Cardiff, UK

      Wanlin Wang

    15. Pharma Mar, S.A., Madrid, Spain

      Eydís Einarsdóttir

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    Correspondence to Detmer Sipkema .

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    Editors and Affiliations

    1. Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

      Pabulo H. Rampelotto

    2. Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Pozzuoli, Naples, Italy

      Antonio Trincone

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    Steinert, G. et al. (2018). BluePharmTrain: Biology and Biotechnology of Marine Sponges. In: Rampelotto, P., Trincone, A. (eds) Grand Challenges in Marine Biotechnology. Grand Challenges in Biology and Biotechnology. Springer, Cham. https://doi.org/10.1007/978-3-319-69075-9_13

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