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Chemical Approaches to Prepare Antimicrobial Polymers

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Polymers against Microorganisms

Abstract

Until the early 1980s, low-molecular weight substances were mainly employed for their antimicrobial activity. However, the discovery of antimicrobial peptides (AMPs) carried out by dramatically changed this situation. This group demonstrated that macromolecular peptides were able to kill Gram-positive bacteria, Gram-negative bacteria, and fungi. AMPs have been extensively developed and today an Antimicrobial Peptide Database (APD). Based on this finding and around the same time antimicrobial polymers known under the name “polymer disinfectants” started to be investigated. As a result, studies on syntheses of polymeric biocides have been started to develop a new utilization field of polymer materials from 1980s. In particular, synthetic polymers have been widely investigated as a new molecular platform to create antimicrobial agents that are active against drug-resistant bacteria.

As will be depicted throughout this chapter, a variety of synthetic polymers with different chemical structures have been utilized to prepare antimicrobial polymers, and some polymers with high efficacy have been reported. In addition, a thorough analysis of the chemical characteristics of antimicrobial polymers and the different strategies to prepare them will be provided.

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  1. Institute of Polymer Science & Technology (ICTP-CSIC), Madrid, Spain

    Juan Rodríguez-Hernández

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Rodríguez-Hernández, J. (2017). Chemical Approaches to Prepare Antimicrobial Polymers. In: Polymers against Microorganisms. Springer, Cham. https://doi.org/10.1007/978-3-319-47961-3_3

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