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Stem Cell Delivery Techniques for Stroke and Peripheral Artery Disease

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Stem Cell Therapy for Vascular Diseases

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Abstract

Stem cells are a nascent therapy for vascular diseases such as stroke and peripheral artery disease. Cells, like any other pharmaceutic agent, need to be delivered to a target organ with an optimal dose and timing to achieve therapeutic effect. A number of techniques, grouped into local, regional, and systemic approaches, have been used in human trials to deliver a variety of stem cells in both stroke and peripheral artery disease. This chapter reviews stem cell therapy for these two diseases with a focus on delivery methods. Technical details as well as the impact of patient, disease, and cell factors for each approach are discussed. Each method’s merits and pitfalls are explored, highlighting the benefit of a diverse set of delivery options for a diverse population of patients.

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Authors and Affiliations

  1. Yale School of Medicine, New Haven, CT, USA

    Shin-Rong Lee & Arash Fereydooni

  2. Vascular Biology and Therapeutics Program and the Departments of Surgery and Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA

    Alan Dardik

Authors
  1. Shin-Rong Lee
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  2. Arash Fereydooni
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  3. Alan Dardik
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Correspondence to Alan Dardik .

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Editors and Affiliations

  1. Department of Surgery, Vascular Surgery Section, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Tulio Pinho Navarro

  2. Postgraduate Program in Sciences Applied to Surgery, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Lara Lellis Navarro Minchillo Lopes

  3. Vascular Biology and Therapeutics Program and the Departments of Surgery and Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA

    Alan Dardik

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Lee, SR., Fereydooni, A., Dardik, A. (2021). Stem Cell Delivery Techniques for Stroke and Peripheral Artery Disease. In: Navarro, T.P., Minchillo Lopes, L.L.N., Dardik, A. (eds) Stem Cell Therapy for Vascular Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-56954-9_3

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  • DOI: https://doi.org/10.1007/978-3-030-56954-9_3

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