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Optical and Optoacoustic Imaging

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Molecular Imaging in Oncology

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 216))

Abstract

The spatiotemporal determination of molecular events and cells is important for understanding disease processes, especially in oncology, and thus for the development of novel treatments. Equally important is the knowledge of the biodistribution, localization, and targeted accumulation of novel therapies as well as monitoring of tumor growth and therapeutic response. Optical imaging provides an ideal versatile platform for imaging of all these problems and questions.

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Abbreviations

2D:

Two-dimensional

3D:

Three-dimensional

ACT:

Adoptive T cell therapy

BLI:

Bioluminescence imaging

BRET:

Bioluminescence resonance energy transfer

CCD:

Charged-coupled device

cRGD:

Cyclic arginine–glycine–aspartic acid

CXCR4:

CXC-Motiv-Chemokine receptor 4

DOX:

Doxorubicin

DR5:

Proapoptotic receptor death receptor 5

ECM:

Extracellular matrix

EGFR:

Epidermal growth factor receptor

EPR:

Enhanced permeability and retention

ER:

Endoplasmic reticulum

FGS:

Fluorescence-guided surgery

FITC:

Fluorescein isothiocyanate

FLIM:

Fluorescence lifetime imaging

FLuc:

Firefly luciferase

FRI:

Fluorescence reflectance imaging

FTI:

Fluorescence transillumination imaging

GFP:

Green fluorescent protein

GLuc:

Gaussia luciferase

GPCR:

G protein-coupled receptor

hASCs:

Human subcutaneous adipose tissue stem cells

HIF:

Hypoxia-inducible factor

hMSCs:

Human mesenchymal stem cells

ICG:

Indo-cyanine green

LLC:

Lewis lung cancer

MICAD:

Molecular Imaging and Contrast Agent Database

MMPs:

Matrix metallopeptidases

MRI:

Magnetic resonance imaging

MSOT:

Multispectral optoacoustic tomography

NFAT:

Nuclear factor of activated T cells

NIR(F):

Near-infrared (fluorescence)

OAI:

Optoacoustic imaging

OVA:

Ovalbumin

PBLs:

Peripheral blood lymphocytes

PCA:

Protein fragment complementation assay

PDGFR:

Platelet-derived growth factor receptor

PEG:

Polyethylene glycol

PKA:

Protein kinase A

PSA:

Prostate-specific antigen

QY:

Quantum yield

RFP:

Red fluorescent protein

RLuc:

Renilla luciferase

SLNs:

Sentinel lymph node(s)

SNR:

Signal-to-noise ratio

SPCD:

Single-photon counting detector

SPR:

Surface plasmon resonance

TILs:

Tumor-infiltrating lymphocytes

TME:

Tumor microenvironment

TNF:

Tumor necrosis factor

TRAIL:

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand

UV:

Ultraviolet

VEGF:

Vascular endothelial growth factor

Vluc:

Vargula luciferase

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Authors and Affiliations

  1. Image-Guided Nanotherapy and Diagnostic (IND), Institute of Diagnostic and Interventional Radiology, University Medical Center Goettingen (UMG), Robert-Koch-Str. 40, 37075, Goettingen, Germany

    Joanna Napp

  2. Translational Molecular Imaging, Max-Planck-Institute for Experimental Medicine, Hermann-Rein-Str. 3, 37075, Goettingen, Germany

    Andrea Markus

  3. Translational Molecular Imaging, Institute of Diagnostic and Interventional Radiology, Clinic of Hematology and Medical Oncology, University Medical Center Goettingen (UMG), Robert-Koch Str. 40, 37075, Goettingen, Germany

    Frauke Alves

  4. Max-Planck-Institute for Experimental Medicine, Hermann-Rein-Str. 3, 37075, Goettingen, Germany

    Frauke Alves

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  3. Frauke Alves
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  1. Department of Nuclear Medicine, University of Münster, Münster, Germany

    Otmar Schober

  2. Institute for Experimental Molecular Imaging, University Hospital, RWTH Aachen University, Aachen, Germany

    Fabian Kiessling

  3. Department of Radiation Oncology, Ruprecht Karl University, Heidelberg, Germany

    Jürgen Debus

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Napp, J., Markus, A., Alves, F. (2020). Optical and Optoacoustic Imaging. In: Schober, O., Kiessling, F., Debus, J. (eds) Molecular Imaging in Oncology. Recent Results in Cancer Research, vol 216. Springer, Cham. https://doi.org/10.1007/978-3-030-42618-7_13

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