Skip to main content
SpringerLink
Log in

Antimicrobial and Hepatoprotective Activities of Edible Mushrooms

  • Chapter
  • First Online:
Biology of Macrofungi

Part of the book series: Fungal Biology ((FUNGBIO))

Abstract

The problem of the existence and prevalence of infectious diseases caused by pathogenic microorganisms in human society is persisted. Many studies have endeavoured to highlight the therapeutic potential of mushrooms. They can produce notable primary and secondary metabolites and could be of great benefit for humans. The largest internal vital organ in the human body is liver. It is responsible for many biochemical molecular interactions that are necessary for humankind.

The liver has multiple functions: (1) it is responsible for making important components of proteins: blood clotting factors and albumin; manufacturing cholesterol, triglycerides and bile that are used to help digest food; the liver is responsible for converting glucose into glycogen; (2) it has an important role in detoxification and allows breaking down medications, alcohols and drugs; (3) liver stores vitamines B12, A, D and K, folic acid and iron. Many diseases may have influence over liver functionality and its proper biological role. The possibilities of the edible mushroom as a general protective, potentionaly curative, antimicrobial and hepatoprotective therapeutic agent are presented in this chapter.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Abah SE, Abah G (2010) Antimicrobial and antioxidant potentials of Agaricus bisporus. Adv Biol Res 4(5):277–282

    Google Scholar 

  • Ahmad N, Mahmood F, Akbar Khalil S, Zamir R, Fazal H, Abbasi BH (2014) Antioxidant activity via DPPH, gram-positive and gram-negative antimicrobial potential in edible mushrooms. Toxicol Ind Health 30(9):826–834

    Article  PubMed  CAS  Google Scholar 

  • Akata I, Ergonul B, Kalyoncu F (2012) Chemical compositions and antioxidant activities of 16 wild edible mushroom species grown in Anatolia. Int J Pharm 8:134–138

    Article  CAS  Google Scholar 

  • Akyüz M, Onganer AN, Erecevit P, Kirbağ S (2010) Antimicrobial activity of some edible mushrooms in the Eastern and Southeast Anatolia region of Turkey. J Sci 3(2):125–130

    Google Scholar 

  • Alam N, Amin R, Khan A, Ara I, Shim MJ, Lee MW, Lee UY, Lee TS (2009) Comparative effects of oyster mushrooms on lipid profile, liver and kidney function in hyper cholesterolemic rats. Mycobiology 37(1):37–42

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Alves MJ, Ferreira ICFR, Martins A, Pintado M (2012a) Antimicrobial activity of wild mushroom extracts against clinical isolates resistant to different antibiotics. J Appl Microbiol 113(2):466–475

    Article  CAS  PubMed  Google Scholar 

  • Alves M, Ferreira ICFR, Dias J, Teixeira V, Martins A, Pintado M (2012b) A Review on antimicrobial activity of mushroom (basidiomycetes) extracts and isolated compounds. Planta Med 78(16):1707–1718

    Article  CAS  PubMed  Google Scholar 

  • Alves MJ, Ferreira ICFR, Dias J, Teixeira V, Martins A (2013) A review on antifungal activity of mushroom extracts and isolated compounds. Curr Top Med Chem 13(21):2648–2659

    Article  CAS  PubMed  Google Scholar 

  • Andrade RJ, Tulkens PM (2011) Hepatic safety of antibiotics used in primary care. J Antimicrob Chemother 66:1431–1446

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Arnao MB, Cano A, Alcolea JF, Acosta M (2017) Estimation of free radical-quenching activity of leaf pigment extracts. Phytohem Anal 12(2):281–286

    Google Scholar 

  • Atila F, Owaid MN, Shariati MA (2017) The nutritional and medical benefits of Agaricus bisporus: a review. J Microbiol Biotechnol Food Sci 7(3):281–286

    Article  CAS  Google Scholar 

  • Auzinger G, Wendon J (2008) Intensive care management of acute liver failure. Curr Opin Crit Care 14(2):179–188

    Article  PubMed  Google Scholar 

  • Babakhin AA, Logina NY, Nolte H, DuBuske LM (1996) Immunomodulating activity of the extract from high mycelium fungus Polyporus squamosus. J Allergy Clin Immunol 97:229

    Article  Google Scholar 

  • Barroetavena C, Toledo CV (2017) The nutritional benefits of mushrooms. In: Ferreira ICFR, Morales P, Barros L (eds) Wild plants, mushrooms and nuts: functional food properties and applications. Wiley-Blackwell, Chichester, pp 65–83

    Google Scholar 

  • Barros L, Cruz T, Baptista P, Estevinho LM, Ferreira IC (2008a) Wild and commercial mushrooms as source of nutrients and nutraceuticals. Food Chem Toxicol 46:2742–2747

    Article  CAS  PubMed  Google Scholar 

  • Barros L, Venturini BA, Baptista P, Estevinho LM, Ferreira ICFR (2008b) Chemical composition and biological properties of Portuguese wild mushrooms: a comprehensive study. J Agric Food Chem 56(10):3856–3862

    Article  CAS  PubMed  Google Scholar 

  • Bawadekji A, Mridha MAU, Al Ali M, Jamith Basha W (2017) Antimicrobial activities of oyster mushroom Pleurotus ostreatus (Jacq. ex. Fr.) Kummer. J Appl Environ Biol Sci 7(10):227–231

    Google Scholar 

  • Bisen PS, Baghel RK, Sanodiya BS, Thakur GS, Prasad GBKS (2010) Lentinus edodes: a macrofungus with pharmacological activities. Curr Med Chem 17:2419–2430

    Article  CAS  PubMed  Google Scholar 

  • Boucher HW, Talbot GH, Bradley JS, Edwards JE, Gilbert D, Rice LB, Scheld M, Spellberg B, Bartlett J (2009) Bad bugs, no drugs: no ESKAPE! An update from the infectious diseases society of America. Clin Infect Dis 48(1):1–12

    Article  PubMed  Google Scholar 

  • Brown GD, Denning DW, Gow NAR, Levitz SM, Netea MG, White TC (2012) Hidden killers: human fungal infections. Sci Transl Med 4:165–213

    Article  CAS  Google Scholar 

  • Caz V, Gil-Ramírez A, Santamaría M, Tabernero M, Soler-Rivas C, Martín-Hernández R, Marín FR, Reglero G, Largo C (2016) Plasma Cholesterol-lowering activity of lard functionalized with mushroom extracts is independent of niemann–pick c1-like 1 protein and abc sterol transporter gene expression in hypercholesterolemic mice. J Agr Food Chem 64(8):1686–1694

    Article  CAS  Google Scholar 

  • Chang ST (2006) The world mushroom industry: trends and technological development. Int J Med Mushrooms 8:297–314

    Article  Google Scholar 

  • Chang ST, Buswell JA (1996) Mushroom nutriceuticals. World J Microbiol Biotechnol 12(5):473–476

    Article  CAS  PubMed  Google Scholar 

  • Chang ST, Miles P (2004) Mushrooms, 2nd edn. CRC Press LLC, Boca Raton

    Book  Google Scholar 

  • Chen L, Shao HJ, Su YB (2004) Coimmunization of Agaricus blazei murill extract with hepatitis B virus core protein through DNA vaccine enhances cellular and humoral immune responses. Int Immunopharmacol 4(3):403–409

    Article  CAS  PubMed  Google Scholar 

  • Chihara G (1992) Immunopharmacology of lentinan, a polysaccharide isolated from Lentinus edodes: its application as a host defence potentiator. Int J Oriental Med 17:55

    Google Scholar 

  • Chowdhury M, Kubra K, Ahmed S, Barros L, Ferreira M, Queiros B et al (2015) Screening of antimicrobial, antioxidant properties and bioactive compounds of some edible mushrooms cultivated in Bangladesh. Ann Clin Microbiol Antimicrob 14(1):8

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ciric L, Tymon A, Zaura E, Lingstrom P, Stauder M, Papetti A, Signoretto C, Pratten J, Wilson M, Spratt D (2011) In Vitro assessment of shiitake mushroom (Lentinula edodes) extract for its antigingivitis activity. J Biomed Biotechnol:507908

    Google Scholar 

  • Coskun O, Kanter M, Korkmaz A, Oter S (2005) Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and β-cell damage in rat pancreas. Pharmacol Res 51:117–123

    Article  CAS  PubMed  Google Scholar 

  • Dandapat S, Sinha MP, Kumar M, Jaggi Y (2015) Hepatoprotective efficacy of medicinal mushroom Pleurotus tuber-regium. Environ Exp Biol 13:103–108

    Google Scholar 

  • David B, Wolfender JL, Dias DA (2015) The pharmaceutical industry and natural products: historical status and new trends. Phytochem Rev 14:299–315

    Article  CAS  Google Scholar 

  • De Silva DD, Rapior S, Sudarman E, Stadler M, Xu J, Alias SA, Hyde KD (2013) Bioactive metabolites from macrofungi: ethnopharmacology, biological activities and chemistry. Fungal Divers 62:1–40

    Article  Google Scholar 

  • Dhanasekaran D, Latha S, Saha S, Thajuddin N, Panneerselvam A (2013) Extracellular biosynthesis, characterisation and in-vitro antibacterial potential of silver nanoparticles using Agaricus bisporus. J Exp Nanosci 8(4):579–588

    Article  CAS  Google Scholar 

  • Dimitrijevic M, Stankov Jovanovic V, Cvetkovic J, Mihajilov-Krstev T, Stojanovic G, Mitic V (2015) Screening of antioxidant, antimicrobial and antiradical activities of twelve selected Serbian wild mushrooms. Anal Methods 7:4181

    Article  CAS  Google Scholar 

  • Dimitrijević MV, Mitić VD, Stankov-Jovanović VP, Nikolić JS, Stojanović GS (2016) Comprehensive evaluation of the antioxidant activity of six wild edible mushroom species. Adv Technol 5(2):53–59

    Article  Google Scholar 

  • Duncan C, Pugh J, Pasco G, David N, Ross S, Samir A (2002) Isolation of a galactomannan that enhances macrophage activation from the edible fungus Morchella esculenta. J Agric Food Chem 50:5683–5685

    Article  CAS  PubMed  Google Scholar 

  • Enman J (2007) Production and quantification of eritadenine, a cholesterol reducing compound in shiitake (Lentinus edodes) [dissertation]. Luleå University of Technology Department of Chemical Engineering and Geosciences Division of Biochemical and Chemical Process Engineering

    Google Scholar 

  • Everhart JE, Ruhl CE (2009) Burden of digestive diseases in the United States Part III: liver, biliary tract, and pancreas. Gastroenterology 136:1134–1144

    Article  PubMed  Google Scholar 

  • FAO (2004) Wild edible fungi: a global overview of their use and importance to people. In: Non-wood forest products. Food and Agriculture Organization of the United Nations, Rome

    Google Scholar 

  • FAO (2009) Make money by growing mushrooms (Elaine Marshall and N. G. (Tan) Nair) rural infrastructure and agro-industries division. Food and Agriculture Organization of the United Nations, Rome

    Google Scholar 

  • FAO Stat (2015) http://faostat.fao.org/site/567/pageID567

  • Fernandes A, Petrović J, Stojković D, Barros L, Glamočlija SM, Anabela M, Isabel F (2016) Polyporus squamosus (Huds.) Fr from different origins: chemical characterization, screening of the bioactive properties and specific antimicrobial effects against Pseudomonas aeruginosa. LWT-Food Sci Technol 69:91–97

    Article  CAS  Google Scholar 

  • Ferreira ICFR, Barros L, Abreu RMV (2009) Antioxidants in wild mushrooms. Curr Med Chem 16(12):1543–1560

    Article  CAS  PubMed  Google Scholar 

  • Finimundy TC, Dillon AJP, Henriques JAP, Ely MR (2014) A Review on general nutritional compounds and pharmacological properties of the Lentinula edodes mushroom. Int J Food Sci Nutr 5:1095–1105

    Google Scholar 

  • Gan CH, Nurul Amira B, Asmah R (2013) Antioxidant analysis of different types of edible mushrooms (Agaricus bisporous and Agaricus brasiliensis). Int Food Res J 20(3):1095–1102

    CAS  Google Scholar 

  • Gargano ML, van Griensven LJLD, Isikhuemhen OS, Lindequist U, Venturella G, Wasser SP, Zervakis GI (2017) Medicinal mushrooms: valuable biological resources of high exploitation potential. Plant Biosyst 151:548–565

    Article  Google Scholar 

  • Gil-Ramírez A, Morales D, Soler-Rivas C (2018) Molecular actions of hypocholesterolaemic compounds from edible mushrooms. Food Funct 9:53–69

    Article  PubMed  Google Scholar 

  • Glamočlija J, Stojković D, Nikolić M, Ćirić A, Barros L, Ferreira IC, Sokovic M (2015) Comparative study on edible agaricus mushrooms as functional foods. Food Funct 6:1900–1910

    Article  PubMed  CAS  Google Scholar 

  • Grinde B, Hetland G, Johnson E (2006) Effects on gene expression and viral load of a medicinal extract from Agaricus blazei in patients with chronic hepatitis C infection. Int Immunopharmacol 6(8):1311–1314

    Article  CAS  PubMed  Google Scholar 

  • Grujičić BD, Potočnik I, Duduk B, Vujčić Z (2015) Spent mushroom compost as substrate for the production of industrially important hydrolytic enzymes by fungi Trichoderma spp. and Aspergillus niger in solid state fermentation. Int Biodeterior Biodegrad 104:290–298

    Article  CAS  Google Scholar 

  • Guillamón E, García-Lafuente A, Lozano M, Arrigo D, Rostagno M, Villares MA et al (2010) Edible mushrooms: role in the prevention of cardiovascular diseases. Fitoterapia 81(7):715–723

    Article  PubMed  CAS  Google Scholar 

  • Hassegawa RH, Kasuya MCM, Vanetti MCD (2005) Growth and antibacterial activity of Lentinula edodes in liquid media supplemented with agricultural wastes. Electron J Biotechnol 8(2):212–217

    Article  CAS  Google Scholar 

  • Hatvani N (2001) Antibacterial effect of the culture fluid of Lentinus edodes mycelium grown in submerged liquid culture. Int J Antimicrob Agents 17:71–74

    Article  CAS  PubMed  Google Scholar 

  • He F, Yang Y, Yang G, Yu L (2010) Studies on antibacterial activity and antibacterial mechanism of a novel polysaccharide from Streptomyces virginia H03. Food Control 21(9):1257–1262

    Article  CAS  Google Scholar 

  • Hearst R, Nelson D, McCollum G, Millar BC, Maeda Y, Goldsmith CE, Rooney PJ, Loughrey A, Rao JR, Moore JE (2009) An examination of antibacterial and antifungal properties of constituents of shiitake (Lentinula edodes) and oyster (Pleurotus ostreatus) mushrooms. Complement Ther Clin Pract 15:5–7

    Article  PubMed  Google Scholar 

  • Heleno SA, Stojković D, Barros L, Glamočlija J, Soković M, Martins A, Queiroz MJ, Ferreira I (2013) A comparative study of chemical composition, antioxidant and antimicrobial properties of Morchella esculenta (L.) Pers. from Portugal and Serbia. Food Res Int 51(1):236–243

    Article  CAS  Google Scholar 

  • Heleno SA, Barros L, Martins A, Morales P, Fernández Ruiz V, Glamoclija J, Sokovic M, Ferreira I (2015) Nutritional value, bioactive compounds, antimicrobial activity and bioaccessibility studies with wild edible mushrooms. LWT-Food Sci Technol 63:799–806

    Article  CAS  Google Scholar 

  • Hirasawa M, Shouji N, Neta T, Fukushima K, Takada K (1999) Three kinds of antibacterial substances from Lentinus edodes (Berk.) Sing. (shiitake, an edible mushroom). Int J Antimicrob Agents 11(2):151–157

    Article  CAS  PubMed  Google Scholar 

  • Hsu CH, Hwang KC, Chiang YH, Chou P (2008) The mushroom Agaricus blazei murill extract normalizes liver function in patients with chronic hepatitis B. J Altern Complement Med 14(3):299–301

    Article  PubMed  Google Scholar 

  • Inuzuka H, Yoshida T (2002) Clinical utility of ABCL (Agaricus Mushroom Extract) treatment for C-type hepatitis. Jpn Pharmacol Ther 30:103–107

    Google Scholar 

  • Iwalokun BA, Usen UA, Otunba AA, Olukoya DK (2007) Comparative phytochemical evaluation, antimicrobial and antioxidant properties of Pleurotus ostreatus. Afr J Biotechnol 6:1732–1739

    Article  CAS  Google Scholar 

  • Jayakumar T, Ramesh E, Geraldine P (2006) Antioxidant activity of the oyster mushroom, Pleurotus ostreatus, on CCl4-induced liver injury in rats. Food Chem Toxicol 44:1989–1996

    Article  CAS  PubMed  Google Scholar 

  • Jeong SC, Jeong YT, Yang BK, Islam R, Koyyalamudi SR, Pang G, Cho KY, Song CH (2010) White button mushroom (Agaricus bisporus) lowers blood glucose and cholesterol levels in diabetic and hypercholesterolemic rats. Nutr Res 30:49–56

    Article  CAS  PubMed  Google Scholar 

  • Kamarudzaman AN, Chay TC, Amir A, Talib SA (2015) Biosorption of Mn (II) ions from aqueous solution by Pleurotus spent mushroom compost in a fixedbed column. Procedia Soc Behav Sci 195:2709–2716

    Article  Google Scholar 

  • Karaman M, Jovin E, Malbasa R, Matavuly M, Popović M (2010) Medicinal and edible lignicolous fungi as natural sources of antioxidative and antibacterial agents. Phytother Res 24:1473–1481

    Article  CAS  PubMed  Google Scholar 

  • Karaman M, Stahl M, Vulić J, Vesić M, Canadanović-Brunet J (2014) Wild-growing lignicolous mushroom species as sources of novel agents with antioxidative and antibacterial potentials. Int J Food Sci Nutr 65(3):311–319

    Article  CAS  PubMed  Google Scholar 

  • Keles A, Koca I, Genccelep H (2011) Antioxidant properties of wild edible mushrooms. J Food Process Technol 2:130

    CAS  Google Scholar 

  • Khan AA, Gani A, Ahmad M, Masoodi FA, Amin F, Kousar S (2016) Mushroom varieties found in the Himalayan regions of India: antioxidant, antimicrobial, and antiproliferative activities. Food Sci Biotechnol 25(4):1095–1100

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Khatua S, Ghosh S, Acharya K (2017) Laetiporus sulphureus (Bull.: Fr.) Murr. as food as medicine. Pharmacogn J 9:1–15

    Article  CAS  Google Scholar 

  • Klančnik A, Megušar P, Sterniša M, Jeršek B, Bucar F, Smole Možina S, Kos J, Sabotič J (2017) Aqueous extracts of wild mushrooms show antimicrobial and antiadhesion activities against bacteria and fungi. Phytother Res 31(12):1971–1976

    Article  PubMed  CAS  Google Scholar 

  • Klaus A, Kozarski M, Vunduk J, Todorovic N, Jakovljevic D, Zizak Z et al (2015) Biological potential of extracts of the wild edible Basidiomycete mushroom Grifola frondosa. Food Res Int 67:272–283

    Article  CAS  Google Scholar 

  • Kostić M, Smiljković M, Petrović J, Glamočilija J, Barros L, Ferreira ICFR, Ćirić A, Soković M (2017) Chemical, nutritive composition and wide-broad bioactive properties of honey mushroom Armillaria mellea (Vahl: Fr.) Kummer. Food Funct 8:3239–3249

    Article  PubMed  Google Scholar 

  • Kozarski M, Klaus A, Jakovljević D, Todorović N, Vunduk J, Petrović P et al (2015) Antioxidants of edible mushrooms. Molecules 20(10):19489–19525

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kubo K, Nanba H (1998) Modifications of cellular immune responses in experimental autoimmune hepatitis in mice by maitake (Grifola frondosa). Mycoscience 39:351–360

    Article  CAS  Google Scholar 

  • Kumar V, Yadav U (2014) Screening of antifungal activity of Pleurotus ostreatus and Agaricus bisporus. Biolife 2(3):918–923

    Google Scholar 

  • Kweon MH, Kwon ST, Kwon SH, Ma MS, Park YI (2002) Lowering effects in plasma cholesterol and body weight by mycelial extracts of two mushrooms: Agaricus blazei and Lentinus edodes. Korean J Microbiol Biotechnol 30:402–409

    Google Scholar 

  • Li M, Hu JL (2014) Study on survival strategies of farmers engage in small-scale household cultivation of edible mushrooms: take Shandong Province as an example. In: Modern economy, vol 5, pp 1092–1100. https://doi.org/10.4236/me.2014.512100

    Article  Google Scholar 

  • Lingstrom P, Zaura E, Hassan H, Buijs MJ, Hedelin P, Pratten J et al (2012) The anticaries effect of a food extract (shiitake) in a short-term clinical study. J Biomed Biotechnol:217164

    Google Scholar 

  • Liu Y, Fukuwatari Z, Okumura K, Takeda K, Ishibashi K, Furukawa M et al. (2008) Immunomodulating activity of Agaricus brasiliensis KA21 in mice and in human volunteers. eCAM 5(2):205–209

    PubMed  Google Scholar 

  • Liu J, Jia L, Kan J, Jin CH (2013) In vitro and in vivo antioxidant activity of ethanolic extract of white button mushroom (Agaricus bisporus). Food Chem Toxicol 51:310–316

    Article  CAS  PubMed  Google Scholar 

  • Liu Q, Zhu M, Geng X, Wang H, Ng TB (2017) Characterization of polysaccharides with antioxidant and hepatoprotective activities from the edible mushroom Oudemansiella radicata. Molecules 22:234–250

    Article  PubMed Central  CAS  Google Scholar 

  • Mau JL, Chang CN, Huang SJ, Chen CC (2004) Antioxidant properties of methanolic extracts from Grifola frondosa, Morchella esculenta and Termitomyces alduminosus mycelia. Food Chem 87:111–118

    Article  CAS  Google Scholar 

  • Mensink RP, Aro A, Den Hond E, German JB, Griffin BA, Ter Meer H-U et al (2003) PASSCLAIM-Diet-related cardiovascular disease. Eur J Nutr 42(11):1/6–1/2

    Google Scholar 

  • Mirunalini S, Arulmozhi V, Deepalakshmi K, Krisnaveni M (2012) Intracellular biosynthesis and antibacterial activity of silver nanoparticles using edible mushrooms. Not Sci Biol 4(4):55

    Article  CAS  Google Scholar 

  • Mlinarič A, Kac J, Pohleven F (2005) Screening of selected wood-damaging fungi for the HIV-1 reverse transcriptase inhibitors. Acta Pharm 55(1):69–79

    PubMed  Google Scholar 

  • Mocan A, Fernandes Â, Barros L, Crişan G, Smiljković M, Soković M, Ferreira ICFR (2018) Chemical composition and bioactive properties of the wild mushroom Polyporus squamosus (Huds.) Fr: a study with samples from Romania. Food Funct 9(1):160–170

    Article  CAS  PubMed  Google Scholar 

  • Morris HJ, Llaurado G, Beltran Y, Lebeque Y, Bermudez RC, Garcia N (2017) The use of mushrooms in the development of functional foods, drugs, and nutraceuticals. In: ICFR F, Morales P, Barros L (eds) Wild plants, mushrooms and nuts: functional food properties and applications. Wiley-Blackwell, Chichester, pp 123–159

    Google Scholar 

  • Mowat AM (2003) Anatomical basis of tolerance and immunity to intestinal antigens. Nat Rev Immunol 3:331–341

    Article  CAS  PubMed  Google Scholar 

  • Mukai H, Watanabe T, Ando M, Katsumata N (2006) An alternative medicine, Agaricus blazei, may have induced severe hepatic dysfunction in cancer patients. Jpn J Clin Oncol 36(12):808–810

    Article  PubMed  Google Scholar 

  • Muriel P (2009) Role of free radicals in liver diseases. Hepatol Int 3:526–536

    Article  PubMed  PubMed Central  Google Scholar 

  • Navarro VJ, Senior JR (2006) Drug-related Hepatotoxicity. N Engl J Med 354:731–739

    Article  CAS  PubMed  Google Scholar 

  • Ndungutse V, Mereddy R, Sultanbawa Y (2015) Bioactive properities of mushroom (Agaricus bisporus) stipe extracts. J Food Process Preserv 39:2225–2233

    Article  CAS  Google Scholar 

  • Nehra K, Kumar M, Yadav A (2012) Evaluation of antimicrobial potential of fruiting body extracts of Pleurotus ostreatus (oyster mushroom). Int J Microbial Resour Technol 1(4):391–400

    Google Scholar 

  • Ngai PHK, Ng TB (2003) Lentin, a novel and potent antifungal protein from shiitake mushroom with inhibitory effects on activity of human immunodeficiency virus-1 reverse transcriptase and proliferation of leukemia cells. Life Sci 73:3363–3364

    Article  CAS  PubMed  Google Scholar 

  • Nikitina EV, Tsivileva MO, Pankratov NA, Bychkov AN (2007) Lentinula edodes biotechnology- from lentinan to lectins. Food technol biotechnol 45:230–237

    CAS  Google Scholar 

  • Nitha D, Meera CR, Janardhanan KK (2007) Anti-inflammatory and antitumour activities of cultured mycelium of morel mushroom, Morchella esculenta. Curr Sci 92:235–239

    Google Scholar 

  • Nitha B, Fijesh PV, Janardhanan KK (2013) Hepatoprotective activity of cultured mycelium of Morel mushroom, Morchella esculenta. Exp Toxicol Pathol 65(1–2):105–112

    Article  CAS  PubMed  Google Scholar 

  • Ochoa-Zarzosa A, Vázquez-Garcidueñas MS, Robinson-Fuentes VA, Vázquez-Marrufo G (2011) Antibacterial and cytotoxic activity from basidiocarp extracts of the edible mushroom Lactarius indigo (Schw.) Fr. (Russulaceae). Afr J Pharm Pharmacol 5(2):281–288

    Article  Google Scholar 

  • Ooi VEC (1996) Hepatoprotective effect of some edible mushrooms. Phytother Res 10:536–538

    Article  Google Scholar 

  • Ooi CEV, Liu F (2000) Immunomodulation and anticancer activity of polysaccharide-protein complexes. Curr Med Chem 7:715–719

    Article  CAS  PubMed  Google Scholar 

  • Owaid MN, Al-Saeedi SSS, Al-Assaffii IAA (2017) Antifungal activity of cultivated oyster mushrooms on various agro-wastes. Summa Phytopathol 43(1):9–13

    Article  Google Scholar 

  • Oyetayo VO, Ariyo OO (2013) Antimicrobial and antioxidant properties of Pleurotus ostreatus (Jacq: Fries) cultivated on different tropical woody substrates. J waste conversion, Bioprod Biotechnol 1(2):28–32

    Google Scholar 

  • Ozturk M, Duru ME, Kivrak S, Dogan NM, Turkoglu A, Ozler MA (2011) In vitro Antioxidant, anticholinesterase and antimicrobial activity studies on three Agaricus species with fatty acid compositions and iron contents: a comparative study on the three most edible mushrooms. Food Chem Toxicol 49:1353–1360

    Article  PubMed  CAS  Google Scholar 

  • Papatheodoridis GV, Dimou E, Papadimitropoulos V (2002) Nucleoside analogues for chronic hepatitis B: antiviral efficacy and viral resistance. Am J Gastroenterol 97:1618–1628

    Article  CAS  PubMed  Google Scholar 

  • Parola S, Chiodaroli L, Orlandi V, Vannini C, Panno L (2017) Lentinula edodes and Pleurotus ostreatus: functional food with antioxidant -antimicrobial activity and an important source of Vitamin D and medicinal compounds. FFHD 7(6):773–794

    Article  Google Scholar 

  • Patel Y, Naraian R, Singh VK (2012) Medicinal properties of Pleurotus species (Oyster Mushroom): a review. World J Fungal Plant Biol 3(1):1–12

    CAS  Google Scholar 

  • Pauliuc I, Dorica B (2013) Antibacterial activity of Pleurotus ostreatus gemmotherapic extract. J Hortic Forestry Biotechnol 17(1):242–245

    Google Scholar 

  • Petrović J, Papandreou M, Glamočlija J, Ćirić A, Baskakis C, Proestos C, Lamari F, Zoumpoulakis P, Sokovic M (2014a) Different extraction methodologies and their influence on the bioactivity of the wild edible mushroom Laetiporus sulphureus (Bull.) Murrill. Food Funct 5:2948–2960

    Article  PubMed  CAS  Google Scholar 

  • Petrović J, Stojković D, Reis FS, Barros L, Glamočlija J, Ćirić A, Ferreira I, Sokovic M (2014b) Study on chemical, bioactive and food preserving properties of Laetiporus sulphureus (Bull.: Fr.) Murr. Food Funct 5:1441–1451

    Article  PubMed  Google Scholar 

  • Petrović J, Ćirić A, Heleno SA, Barros L, Ferreira ICFR, Glamočlija J, Soković M (2016) Pleurotus ostreatus (Jacq.ex Fr.) P. K.: a highly nutritious edible mushroom cultivated in Serbia as a potential remedy for chronic infectious diseases. Proceedings of the 13th congress of nutrition, food and nutrition – a roadmap to better health; 2016 October 26–28; Belgrade

    Google Scholar 

  • Poli G (1993) Liver damage due to free radicals. Br Med Bull 49:604–600

    Article  CAS  PubMed  Google Scholar 

  • Quang DN, Hashimoto T, Asakawa Y (2006) Inedible mushrooms: a good source of biologically active substances. Chem Rec 6:79–99

    Article  CAS  PubMed  Google Scholar 

  • Rajewska J, Bałasińska B (2004) Biologically active compounds of edible mushrooms and their beneficial impact on health. Postepy Hig Med Dosw 58:352–357

    Google Scholar 

  • Ramesh CH, Pattar MG (2010) Antimicrobial properties, antioxidant activity and bioactive compounds from six wild edible mushrooms of Western Ghats of Karnataka, India. Pharmacognosy Res 2(2):107–112

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rana T, Bera AK, Das S, Bhattacharya D, Pan D, Bandyopadhyay S, Mondal DK, Samanta S, Bandyopadhyay S, Das SK (2012) Pleurotus florida lectin normalizes duration dependent hepatic oxidative stress responses caused by arsenic in rat. Exp Toxicol Pathol 64(7–8):665–671

    Article  CAS  PubMed  Google Scholar 

  • Rao JR, Smyth TJ, Millar BC, Moore JE (2009) Antimicrobial properties of shiitake mushrooms (Lentinula edodes). Int J Antimicrob Agents 3:591–592

    Article  CAS  Google Scholar 

  • Reis FS, Martins A, Barros L, Ferreira ICFR (2012) Antioxidant properties and phenolic profile of the most widely appreciated cultivated mushrooms: a comparative study between in vivo and in vitro samples. Food Chem Toxicol 50:1201–1207

    Article  CAS  PubMed  Google Scholar 

  • Reis FS, Martins A, Vasconcelos MH, Morales P, Ferreira ICFR (2017) Functional foods based on extracts or compounds derived from mushrooms. Trends Food Sci Technol 66:48–62

    Article  CAS  Google Scholar 

  • Rincão VP, Yamamoto KA, Ricardo NMPS, Soares SA, Meirelles LDP, Nozawa C, Linhares RE (2012) Polysaccharide and extracts from Lentinula edodes: structural features and antiviral activity. Virol J 9:37

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Robaszkiewicz A, Bartosz G, Lawrynowicz M, Soszynski M (2010) The role of polyphenols, β-carotene, and lycopene in the antioxidative action of the extracts of dried, edible mushrooms. J Nutr Metab 42:1–9

    Article  CAS  Google Scholar 

  • Rosmiza M, Davies W, Aznie RC, Jabil M, Mazdi M (2016) Prospects for increasing commercial mushroom production in malaysia: challenges and opportunities. Mediterr J Soc Sci 7:406–415

    Google Scholar 

  • Roy DN, Azad AK, Sultana F, Anisuzzaman ASM (2016) In-vitro antimicrobial activity of ethyl acetate extract of two common edible mushrooms. J Pharmacol 5(2):79–82

    Google Scholar 

  • Roupas P, Keogh J, Noakes M, Margetts C, Taylor P (2012) The role of edible mushrooms in health: evaluation of the evidence. J Funct Foods 4(4):687–689

    Article  CAS  Google Scholar 

  • Sánchez C (2017a) Bioactives from mushroom and their application. In: Puri M (ed) Food Bioactives. Springer International Publishing, Cham, pp 23–27

    Chapter  Google Scholar 

  • Sánchez C (2017b) Reactive oxygen species and antioxidant properties from mushrooms. Synth Syst Biotechnol 2(1):13–22

    Article  PubMed  Google Scholar 

  • Schwan WR (2012) Mushrooms: an untapped reservoir for nutraceutical antibacterial applications and antibacterial compounds. Curr Top Nutraceutical Res 10(1):75–82

    CAS  Google Scholar 

  • Seeff LB, Lindsay KL, Bacon BR, Kresina TF, Hoofnagle JH (2001) Complementary and alternative medicine in chronic liver disease. Hepatology 34(3):595–603

    Article  CAS  PubMed  Google Scholar 

  • Seif HAS (2016) Physiological changes due to hepatotoxicity and the protective role of some medicinal plants. Beni–Suef Univ J Basic Appl Sci 5:134–136

    Article  Google Scholar 

  • Sharma MV, Sagar A, Joshi M (2015) Study on antibacterial activity of Agaricus bisporus (Lang.) Imbach. Int J Curr Microbiol App Sci 4(2):553–558

    CAS  Google Scholar 

  • Sherry D, McCulloch A, Liang Q, Reimann S, Newman PA (2018) Current sources of carbon tetrachloride (CCl4) in our atmosphere. Environ Res Lett 13:024004

    Article  Google Scholar 

  • Smolskaite L, Petras RV, Thierry T (2015) Comprehensive evaluation of antioxidant and antimicrobial properties of different mushroom species. LWT-Food Sci Technol 60:462–471

    Article  CAS  Google Scholar 

  • Soares AA, de Sá-Nakanishi AB, Bracht A, da Costa SMG, Koehnlein EA, de Cristina Giatti Souza M, Peralta RM (2013a) Hepatoprotective effects of mushrooms. Molecules 18:7609–7630

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Soares AA, de Oliveira AL, de Sá-Nakanishi AB, Comar JF, Rampazzo APS, Vicentini FA, Natali MRM, Costa SM, Bracht A, Peralta RM (2013b) Effects of an Agaricus blazei aqueous extract pretreatment on paracetamol-induced brain and liver injury in rats. Biomed Res Int 469180

    Google Scholar 

  • Soković M, Glamočlija J, Ćirić A (2013) Natural products from plants and fungi as fungicides. In: Nita M (ed) Fungicides-showcases of integrated plant disease management from around the world. InTech, New York, pp 185–232

    Google Scholar 

  • Soković M, Ćirić A, Glamočlija J, Nikolić M, van Griensven LJLD (2014) Agaricus Blazei hot water extract shows anti quorum sensing activity in the nosocomial human pathogen Pseudomonas aeruginosa. Molecules 19(4):4189–4199

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Soković M, Ćirić A, Glamočlija J, Stojković D (2017) The bioactive properties of mushrooms. In: Ferreira ICFR, Morales P, Barros L (eds) Wild plants, mushrooms and nuts: functional food properties and applications. Wiley-Blackwell, Chichester

    Google Scholar 

  • Soković M, Glamočlija J, Ćirić A, Petrović J, Stojković D (2018) Mushrooms as sources of therapeutic foods. In: Holban AM, Grumezescu AM (eds) Therapeutic foods, handbook of food bioengineering. Elsevier Inc, London

    Chapter  Google Scholar 

  • Spratt DA, Daglia M, Papetti A, Stauder M, O’Donnell D, Ciric L, Tymon A, Repetto B, Signoretto C, Houri-Haddad Y, Feldman M, Steinberg D, Lawton S, Longstrom P, Pratten J, Zaura E, Gazzani G, Pruzzo C, Wilson M (2012) Evaluation of plant and fungal extracts for their potential antigingivitis and anticaries activity. J Biomed Biotechnol:510198

    Google Scholar 

  • Stajić M, Vukojević J, Knežević A, Duletić Laušević S, Milovanović I (2013) Antioxidant protective effect of mushroom metabolites. Curr Top Med Chem 13:2660–2676

    Article  CAS  PubMed  Google Scholar 

  • Stojković D, Reis FS, Barros L, Glamočlija J, Ćirić A, van Griensven LJ et al (2013) Nutrients and non-nutrients composition and bioactivity of wild and cultivated Coprinus comatus (O.F. Müll.) Pers. Food Chem Toxicol 59:289–296

    Article  PubMed  CAS  Google Scholar 

  • Stojković D, Reis FS, Glamočlija J, Ćirić A, Barros L, JLD van Griensven L et al (2014) Cultivated strains of Agaricus bisporus and A. brasiliensis: chemical characterization and evaluation of antioxidant and antimicrobial properties for final healthy product - natural preservatives in yoghurt. Food Funct 5:1602–1612

    Article  PubMed  CAS  Google Scholar 

  • Stojković DS, Kovačević-Grujičić N, Reis FS, Davidović S, Barros L, Popović J, Petrovic I, Pavic A, Ciric A, Stevanovic M (2017) Chemical composition of the mushroom Meripilus giganteus Karst. and bioactive properties of its methanolic extract. LWT-Food Sci Technol 79:454–462

    Article  CAS  Google Scholar 

  • Suay I, Arenal F, Asensio FJ, Basilio A, Cabello MA, Diey MT, Garcia JB, Del Val AG, Gorrochategui J, Hernandez P, Pelaez F, Vicente MF (2000) Screening of basidiomycetes for antimicrobial activities. Antonie van Leeuwenhoek 78:129–139

    Article  CAS  PubMed  Google Scholar 

  • Sudhakar T, Nanda A, Babu SG, Janani S, Evans MD, Markose TK (2014) Synthesis of silver nanoparticles from edible mushroom and its antimicrobial activity against human pathogens. Int J Pharmtech Res 6(5):1718–1723

    CAS  Google Scholar 

  • Tehrani MHH, Fakhrehoseini E, Nejad MK, Mehregan H, Hakemi-Vala M (2012) Search for proteins in the liquid extract of edible mushroom, Agaricus bisporus, and studying their antibacterial effects. Iran J Pharm Res 1(1):145–150

    Google Scholar 

  • Tel G, Ozturk M, Duru ME, Turkoglu A (2015) Antioxidant and anticholinesterase activities of five wild mushroom species with total bioactive contents. Pharm Biol 53:824–830

    Article  CAS  PubMed  Google Scholar 

  • Toshiro W, Ayako K, Satoshi I, Kumar MT, Shiro N, Keisuke T (2003) Antihypertensive effect of gamma-aminobutyric acid-enriched Agaricus blazei on mild hypertensive human subjects. J Jpn Soc Food Sci Technol 50:167–173

    Article  Google Scholar 

  • Turkoglu A, Kivrak I, Mercan N, Duru ME, Gezer K, Turkoglu H (2006) Antioxidant and antimicrobial activities of Morchella conica Pers. Afr J Biotechnol 5(11):1146–1150

    CAS  Google Scholar 

  • Uddin GM, Hossain S, Monirul Islam M, Asaduzzaman M, Bulbul J, Amin R (2015) Evaluation of antimicrobial, antioxidant and cytotoxic property of Pleurotus ostreatus mushroom. Int Res J Biol Sci 4(1):29–33

    Google Scholar 

  • Ul-Haq M, Rathod V, Singh D, Singh AK, Ninganagouda S, Hiremath J (2015) Dried Mushroom Agaricus bisporus mediated synthesis of silver nanoparticles from Bandipora District (Jammu and Kashmir) and their efficacy against Methicillin Resistant Staphylococcus aureus (MRSA). Nanosci Nanotechnol Int J 5(1):1–8

    Google Scholar 

  • Valverde ME, Hernandez-Perez T, Paredes-Lopez O (2015) Edible mushrooms: improving human health and promoting quality life. Int J Microbiol:376387

    Google Scholar 

  • Vamanu E (2012) Determination of antioxidant and antimicrobial properties of Agaricus bisporus from Romanian markets. Ovidius University Annals of Chemistry, Constanta, pp 47–52

    Google Scholar 

  • Van Hoek AHAM, Mevius D, Guerra B, Mullany P, Roberts AP, Aarts HJM (2011) Acquired antibiotic resistance genes: an overview. Front Microbiol 28:203

    Google Scholar 

  • Venturini ME, Rivere CS, Gonsalez C, Blanco D (2008) Antimicrobial activity of extracts of edible wild and cultivated mushrooms against foodborne bacterial strains. J Food Prot 71(8):1701–1706

    Article  CAS  PubMed  Google Scholar 

  • Vieira V, Fernandes A, Barros L, Glamočlija J, Ćirić A, Stojković D, Martins A, Soković M, Ferreira ICFR (2015) Wild Morchella conica Pers. from different origins: a comparative study of nutritional and bioactive properties. J Sci Food Agr 96:90–98

    Article  CAS  Google Scholar 

  • Waithaka PN, Gathuru EM, Githaiga BM, Onkoba KM (2017) Antimicrobial activity of mushroom (Agaricus bisporus) and fungal (Trametes gibbosa) extracts from mushrooms and fungi of Egerton Main Campus. J Biomed Sci Eng 6:3

    Google Scholar 

  • Wang HJ, Zakhari S, Jung MK (2010) Alcohol, inflammation, and gut-liver-brain interactions in tissue damage and disease development. World J Gastroenterol 16(11):1304–1313

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang H, Fu Z, Han C (2013) The medicinal values of culinary-medicinal royal sun mushroom (Agaricus blazei Murrill). Evid Based Complement Alternat Med:842619

    Google Scholar 

  • Wasser SP (2014) Medicinal mushroom science: current perspectives, advances, evidences, and challenges. Biomed J 37:345–346

    Article  PubMed  Google Scholar 

  • Wasser SP, Weis AL (1999) Therapeutic effects of substances occurring in higher Basidiomycetes mushrooms: a modern perspective. Crit Rev Immunol 19:65–66

    CAS  PubMed  Google Scholar 

  • Wilson JW, Schurr MJ, LeBlanc CL, Ramamurthy R, Buchanan KL, Nickerson CA (2002) Mechanisms of bacterial pathogenicity. Postgrad Med J 78:216–224

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wolff ERS, Wisbeck E, Silveira MLL, Gern RMM, Pinho MSL, Furlan SA (2008) Antimicrobial and antineoplasic activity of Pleurotus ostreatus. Appl Biochem Biotechnol 151:402–412

    Article  CAS  PubMed  Google Scholar 

  • Wu MF, Hsu YM, Tang MC, Chen HC, Chung JG, Lu HF, Lin JP, Tang NY, Yeh C, Yeh MY (2011) Agaricus blazei Murill extract abrogates CCl14-induced liver injury in rats. In Vivo 225(1):35–40

    Google Scholar 

  • Xu G, Huang X, Qiu L, Wu J, Hu Y (2007) Mechanism study of chitosan on lipid metabolism in hyperlipidemic rats. Asia Pac J Clin Nutr 16(1):313–317

    CAS  PubMed  Google Scholar 

  • Yoon KN, Alam N, Lee JS, Cho HJ, Kim HY, Shim MJ, Lee MW, Lee TS (2011) Antihyperlipidemic effect of dietary Lentinus edodes on plasma, feces and hepatic tissues in hypercholesterolemic rats. Mycobiology 39:96–102

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yu J, Cui PJ, Zeng WL, Xie XL, Liang WJ, Lin GB, Zeng L (2009) Protective effect of selenium-polysaccharides from the mycelia of Coprinus comatus on alloxan-induced oxidative stress in mice. Food Chem 117:42–47

    Article  CAS  Google Scholar 

  • Zhang A, Sun H, Wang X (2013) Recent advances in natural products from plants for treatment of liver diseases. Eur J Med Chem 63:570–577

    Article  CAS  PubMed  Google Scholar 

  • Zhao H, Lan Y, Liu H, Zhu Y, Liu W, Zhang J, et al. (2017) Aantioxidant and hepatoprotective activities of polysaccharides from spent mushroom substrates (Laetiporus sulphureus) in acute alcohol-induced mice. Oxi Med Cell Longev 5863523, 12

    Google Scholar 

  • Zhu P (2009) The present status and prospects of medicinal fungal research and development in China. In: Proceeding of the 5th international medicinal mushroom conference, Nantong, China

    Google Scholar 

  • Zhu HJ, Sheng K, Yan EF, Qiao JJ, Lv F (2012) Extraction, purification and antibacterial activities of a polysaccharide from spent mushroom substrate. Int J Biol Macromol 5(3):840–843

    Article  CAS  Google Scholar 

Download references

Acknowledgement

The authors thank Serbian Ministry of Education, Science and Technological Development for financial support (grant number 173032).

Author information

Authors and Affiliations

  1. Department of Plant Physiology, Institute for Biological Research “Siniša Stanković”, University of Belgrade, Belgrade, Serbia

    Jasmina Glamočlija, Marina Kostić & Marina Soković

Authors
  1. Jasmina Glamočlija
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Marina Kostić
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Marina Soković
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Marina Soković .

Editor information

Editors and Affiliations

  1. Molecular Microbiology and Systematics Laboratory, Department of Biotechnology, Mizoram University, Aizawl, Mizoram, India

    Bhim Pratap Singh

  2. Molecular Microbiology and Systematics Laboratory, Department of Biotechnology, Mizoram University, Aizawl, Mizoram, India

    Lallawmsanga

  3. Molecular Microbiology and Systematics Laboratory, Department of Biotechnology, Mizoram University, Aizawl, Mizoram, India

    Ajit Kumar Passari

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Glamočlija, J., Kostić, M., Soković, M. (2018). Antimicrobial and Hepatoprotective Activities of Edible Mushrooms. In: Singh, B., Lallawmsanga, Passari, A. (eds) Biology of Macrofungi. Fungal Biology. Springer, Cham. https://doi.org/10.1007/978-3-030-02622-6_4

Download citation

Publish with us

Policies and ethics

Search

Navigation