Abstract
Exploration of natural sources for novel bioactive compounds has been an emerging field of medicine over the past decades, providing drugs or lead compounds of considerable therapeutic potential. This research has provided exciting evidence on the isolation of microbe-derived metabolites having prospective biological activities. Mushrooms have been valued as traditional sources of natural bioactive compounds for many centuries and have been targeted as promising therapeutic agents. Many novel biologically active compounds have been reported as a result of research on medicinal mushrooms. In this review, we compile the information on bioactive structure-elucidated metabolites from macrofungi discovered over the last decade and highlight their unique chemical diversity and potential benefits to novel drug discovery. The main emphasis is on their anti-Alzheimer, anti-diabetic, anti-malarial, anti-microbial, anti-oxidant, anti-tumor, anti-viral and hypocholesterolemic activities which are important medicinal targets in terms of drug discovery today. Moreover, the reader’s attention is brought to focus on mushroom products and food supplements available in the market with claimed biological activities and potential human health benefits.
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References
Abraham WR (2001) Bioactive Sesquiterpenes produced by fungi: are they useful for humans as well? Curr Med Chem 8:583–606
Abrams DI, Couey P, Shade SB, Kelly ME, Kamanu-Elias N, Stamets P (2011) Antihyperlipidemic effects of Pleurotus ostreatus (oyster mushrooms) in HIV-infected individuals taking antiretroviral therapy. BMC Complement Altern Med 11:60. doi:10.1186/1472-6882-11-60
Adams M, Christen M, Plitzko I, Zimmermann S, Brun R, Kaiser M, Hamburger M (2010) Antiplasmodial lanostanes from the Ganoderma lucidum mushroom. J Nat Prod 73:897–900
Agrawal RP, Chopra A, Lavekar GS, Padhi MM, Srikanth N, Ota S, Jain S (2010) Effect of oyster mushroom on glycemia, lipid profile and quality of life in type 2 diabetic patients. Aust J Med Herbalism 22:50–54
Akata I, Ergonul B, Kalyoncu F (2012) Chemical compositions and antioxidant activities of 16 wild edible mushroom species grown in Anatolia. Int J Pharmacol 8:134–138
Akihisa T, Uchiyama E, Kikuchi T, Tokuda H, Suzuki T, Kimura Y (2009) Anti-tumor-promoting effects of 25-methoxyporicoic acid A and other triterpene acids from Poria cocos. J Nat Prod 72:1786–1792
Alam N, Amin R, Khan A, Ara I, Shim MJ, Lee MW, Lee TS (2008) Nutritional analysis of cultivated mushrooms in Bangladesh: Pleurotus ostreatus, Pleurotus sajor-caju, Pleurotus florida and Calocybe indica. Mycobiology 36:228–232
Alam N, Yoon KN, Lee KR, Shin PG, Cheong JC, Yoo YB, Shim MJ, Lee MW, Lee UY, Lee TS (2010) Antioxidant activities and tyrosinase inhibitory effects of different extracts from Pleurotus ostreatus fruiting bodies. Mycobiology 38:295–301
Alarcón J, Aguila S (2006) Lovastatin production by Pleurotus ostreatus: effects of the C:N ratio. Z Naturforsch C 61(1–2):95–98
Alexandre J, Raymond E, Kaci MO, Brain EC, Lokiec FO, Kahatt C, Faivre S, Yovine A (2004) Phase I and pharmacokinetic study of irofulven administered weekly or biweekly in advanced solid tumor patients. Clin Cancer Res 10:3377–3385
Alexandre J, Kahatt C, Bertheault-Cvitkovic F, Faivre S, Shibata S, Hilgers W, Goldwasser F, Lokiec F, Raymond E, Weems G, Shah A, MacDonald JR, Cvitkovic E (2007) A phase I and pharmacokinetic study of irofulven and capecitabine administered every 2 weeks in patients with advanced solid tumors. Invest New Drugs 25:453–462
Alfadda AA, Sallam RM (2012) Reactive oxygen species in health and disease. J Biomed Biotechnol. doi:10.1155/2012/936486 (ID 936486, 14 pages)
Ali MK, Bullard KM, Imperatore G, Barker L, Gregg EW (2012) Characteristics associated with poor glycemic control among adults with self-reported diagnosed diabetes—National health and nutrition examination survey, United States, 2007–2010. MMWR Morb Mortal Wkly Rep 61(2):32–37
Alonso A, Zaidi T, Novak M, Grundke-Iqbal I, Iqbal K (2001) Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments. Proc Natl Acad Sci U S A 98(12):6923–6928
Alves MJ, Ferreira IC, Dias J, Teixeira V, Martins A, Pintado M (2012a) A review on antimicrobial activity of mushroom (Basidiomycetes) extracts and isolated compounds. Planta Med 78(16):1707–1718
Alves MJ, Ferreira IC, Martins A, Pintado M (2012b) Antimicrobial activity of wild mushroom extracts against clinical isolates resistant to different antibiotics. J Appl Microbiol 113(2):466–475
Aly AH, Debbab A, Kjer J, Proksch P (2010) Fungal endophytes from higher plants: a prolific source of phytochemicals and other bioactive natural products. Fungal Divers 41:1–16
Aly AH, Debbab A, Proksch P (2011) Fifty years of drug discovery from fungi review. Fungal Divers 50:3–19
Ameri A, Vaidya JG, Deokule SS (2011) In vitro evaluation of anti-staphylococcal activity of Ganoderma lucidum, Ganoderma praelongum and Ganoderma resinaceum from Pune, India. Afr J Microbiol Res 5(3):328–333
Anand P, Kunnumakara AB, Sundaram C, Harikumar KB, Tharakan ST, Lai OS, Sung B, Aggarwal BB (2008) Cancer is a preventable disease that requires major lifestyle changes. Pharm Res 25:2097–2116
Anderson JW (2009) All fibers are not created equal. J Med 2(2):87–91
Andrade RJ, Tulkens PM (2011) Hepatic safety of antibiotics used in primary care. J Antimicrob Chemother 66(7):1431–1446
Anonymous (2008) Alzheimer’s Association. 2008 Alzheimer’s disease facts and figures. Alzheimers Dement 4:110–133
Anonymous (2010) Position of the American dietetic association: integration of medical nutrition therapy and pharmacotherapy. J Am Diet Assoc 110:950–956
Anthony MP, Burrows JN, Duparc S, Moehrle JJ, Wells TNC (2012) The global pipeline of new medicines for the control and elimination of malaria. Malar J 11:316. doi:10.1186/1475-2875-11-316
Arpha K, Phosri C, Suwannasai N, Mongkolthanaruk W, Sodngam S (2012) Astraodoric acids A-D: new lanostane triterpenes from edible mushroom Astraeus odoratus and their anti-Mycobacterium tuberculosis H37Ra and cytotoxic activity. J Agric Food Chem 60(39):9834–9841
Aryantha NP, Kusmaningati S, Sutjiatmo AB, Sumartini Y, Nursidah A, Narvikasari S (2010) The effect of Laetiporus sp. (Bull. ex Fr.) Bond. et Sing. (Polyporaceae) extract on total blood cholesterol level. Biotechnology 9:312–318
Asada C, Asakawa A, Sasaki C, Nakamura Y (2011) Characterization of the steam-exploded spent Shiitake mushroom medium and its efficient conversion to ethanol. Bioresour Technol 102(21):10052–10056
Atli B, Yamac M (2012) Screening of medicinal higher basidiomycetes mushrooms from turkey for lovastatin production. Int J Med Mushrooms 14(2):149–159
Ayala-Zavala JF, Silva-Espinoza BA, Cruz-Valenzuela MR, Villegas-Ochoa MA, Esqueda M, González-Aguilar GA, Calderón-López Y (2012) Antioxidant and antifungal potential of methanol extracts of Phellinus spp. from Sonora, Mexico. Rev Iberoam Micol 29(3):132–138
Ayodele SM, Okhuoya JA (2009) Nutritional and phytochemical evaluation of cultivated Psathyrella atroumbonata Pegler, a Nigerian edible mushroom. S Afr J Sci 105(3–4):158–160
Badole SL, Shah SN, Patel NM, Thakurdesai PA, Bodhankar SL (2006) Hypoglycemic activity of aqueous extract of Pleurotus pulmonarius in alloxan-induced diabetic mice. Pharm Biol 44:421–425
Bao X, Duan J, Fang X, Fang J (2001) Chemical modifications of the (1 → 3)-α-D-glucan from spores of Ganoderma lucidum and investigation of their physicochemical properties and immunological activity. Carbohydr Res 336:127–140
Barrios-Garcia HB, Guizarnotegui-Blanco JA, Zapata-Campos CC, Almazan-Garcia C, Gonzalez-Alanis P, Villareal-Pena R, Hernandez-Jarguin A, Miranda-Hernandez DU, Martinez-Burnes J (2012) Identification of Mycobacterium tuberculosis complex by histopathology and PCR in white-tailed deer (Odocoileus virginianus) in Tamaulipas, Mexico. J Anim Vet Adv 11(7):1036–1040
Barros L, Calhelha RC, Vaz JA, Ferreira ICFR, Baptista P, Estevinho LM (2007) Antimicrobial activity and bioactive compounds of Portuguese wild edible mushrooms methanolic extracts. Eur Food Res Technol 225:151–156
Batista R, Silva ADJ, de Oliveira AB (2009) Plant-derived antimalarial agents: new leads and efficient phytomedicines. Part II: non-alkaloidal natural products. Molecules 14:3037–3072
Becker DJ, Gordon RY, Halbert SC, French B, Morris PB, Rader DJ (2009) Red yeast rice for dyslipidemia in statin-intolerant patients: a randomized trial. Ann Intern Med 150:830–839
Benzie IF (2003) Evolution of dietary antioxidants. Comp Biochem Physiol A Mol Integr Physiol 136(1):113–126
Bergendiova K, Tibenska E, Majtan J (2011) Pleuran (β-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes. Eur J Appl Physiol 111(9):2033–2040
Bhattarai G, Lee YH, Lee NH, Lee IK, Yun BS, Hwang PH, Yi HK (2012) Fomitoside-K from Fomitopsis nigra induces apoptosis of human oral squamous cell carcinomas (YD-10B) via mitochondrial signaling pathway. Biol Pharm Bull 35(10):1711–1719
Biggerstaff KD, Wooten JS (2004) Understanding lipoproteins as transporters of cholesterol and other lipids. Adv Physiol Educ 28(1–4):105–106
Blackwell M (2011) The fungi: 1, 2, 3 … 5.1 million species? Am J Bot 98(3):426–438
Bobek P, Ondreicka R, Klvanova J, Ozdin L (1994) Oyster mushroom (Pleurotus ostreatus) decreases serum and liver cholesterol and increase cholesterol 7β-hydroxylase activity and fecal excretion of neutral sterols and bile acids in hypercholesterolemic rats. Nutr Res 14:1689–1699
Bobek P, Hromadova M, Ozdin L (1995) Oyster mushroom (Pleurotus ostreatus) reduces the activity of 3-hydroxy-3-methylglutaryl CoA reductase in rat liver microsomes. Experientia 51:589–591
Bobek P, Ozdin L, Galbavy S (1998) Dose- and time-dependent hypocholesterolemic effect of oyster mushroom (Pleurotus ostreatus) in rats. Nutrition 14:282–2826
Bobovcak M, Kuniakova R, Gabriz J, Majtan J (2010) Effect of Pleuran (beta-glucan from Pleurotus ostreatus) supplementation on cellular immune response after intensive exercise in elite athletes. Appl Physiol Nutr Metab 35(6):755–762
Borchers AT, Krishnamurthy A, Keen CL, Meyers FJ, Gershwin ME (2008) The immunobiology of mushrooms. Exp Biol Med (Maywood) 233:259–276
Boucher HW, Corey GR (2008) Epidemiology of methicillin-resistant Staphylococcus aureus. Clin Infect Dis 46(5):S344–S349
Boucher HW, Talbot GH, Bradley JS, Edwards JE, Gilbert D, Rice LB, Scheld M, Spellberg B, Bartlett J (2009) Bad bugs, no drugs: no ESKAPE! An update from the infectious diseases society of America. Clin Infect Dis 48(1):1–12
Brakhage AA (2013) Regulation of fungal secondary metabolism. Nat Rev Microbiol 11(1):21–32
Brennan MA, Derbyshire E, Tiwari BK, Brennan CS (2012) Enrichment of extruded snack products with coproducts from chestnut mushroom (Agrocybe aegerita) production: interactions between dietary fiber, physicochemical characteristics, and glycemic load. J Agric Food Chem 60:4396–4401
Carayol M, Grosclaude P, Delpierre C (2010) Prospective studies of dietary alpha-linolenic acid intake and prostate cancer risk: a meta-analysis. Cancer Causes Control 21(3):347–355
Carayol M, Bernard P, Boiché J, Riou F, Mercier B, Cousson-Gélie F, Romain AJ, Delpierre C, Ninot G (2013) Psychological effect of exercise in women with breast cancer receiving adjuvant therapy: what is the optimal dose needed? Ann Oncol 24(2):291–300
Cassels BK, Asencio M (2011) Anti-HIV activity of natural triterpenoids and hemisynthetic derivatives 2004–2009. Phytochem Rev 10:545–564
CDC Centers for Disease control and prevention (2011) Chronic disease prevention and health promotion. Cancer addressing the cancer burden at a glance 2011. http://www.cdc.gov/nccdphp/publications/aag/dcpc.htm
Celermajer DS, Chow CK, Marijon E, Anstey NM, Woo KS (2012) Cardiovascular disease in the developing world: prevalences, patterns, and the potential of early disease detection. J Am Coll Cardiol 60(14):1207–1216
Centko RM, Ramón-García R, Taylor T, Patrick BO, Thompson CJ, Miao VP, Andersen RJ (2012) Ramariolides A–D, antimycobacterial butenolides isolated from the mushroom Ramaria cystidiophora. J Nat Prod 75:2178–2182
Chang UM, Li CH, Lin LI, Huang CP, Kan LS, Lin SB (2006) Ganoderiol F, a Ganoderma triterpene, induces senescence in hepatoma HepG2 cells. Life Sci 79:1129–1139
Chen DH, Chen WKD (2003) Determination of ganoderic acids in triterpenoid constituents of Ganoderma tsugae. J Food Drug Anal 11:195–201
Chen J, Seviour R (2007) Medicinal importance of fungal β-(1 → 3), (1 → 6) glucans. Mycol Res 111:635–652
Chen CC, Shiao YJ, Lin RD, Shao YY, Lai MN, Lin CC, Ng LT, Kuo YH (2006) Neuroprotective diterpenes from the fruiting body of Antrodia camphorata. J Nat Prod 69:689–691
Chen NH, Liu JW, Zhong JJ (2008) Ganoderic acid Me inhibits tumor invasion through down-regulating matrix metalloproteinases 2/9 gene expression. J Pharmacol Sci 108:212–216
Chen H, Lu X, Qu Z, Wang Z, Zhang L (2010) Glycosidase inhibitory activity and antioxidant properties of a polysaccharide from mushroom Inonotus obliquus. J Food Biochem 34:178–191
Chen G, Luo YC, Ji BP, Li B, WeiSu W, Xiao ZL, Zhang GZ (2011) Hypocholesterolemic effects of Auricularia auricula ethanol extract in ICR mice fed a cholesterol-enriched diet. J Food Sci Technol 48(6):692–698
Chen J, Zhao RL, Karunarathna SC, Callac P, Raspe O, Bahkali AH, Hyde KD (2012) Agaricus megalosporus: a new species in section Minores. Cryptog Mycol 33(2):145–155
Cheng CR, Yue QX, Wu ZY, Song XY, Tao SJ, Wu XH, Xu PP, Liu X, Guan SH, Guo DA (2010) Cytotoxic triterpenoids from Ganoderma lucidum. Phytochemistry 71:1579–1585
Cheng YW, Chen YI, Tzeng CY, Chen HC, Tsai CC, Lee YC, Lin JG, Lai YK, Chang SL (2012) Extracts of Cordyceps militaris lower blood glucose via the stimulation of cholinergic activation and insulin secretion in normal rats. Phytother Res 26(8):1173–1177
Cheung PC (2008) Mushrooms as functional foods. Wiley, New Jersey. 1:268 pp
Chin SK, Law CL, Cheng PG (2011) Effect of drying on crude ganoderic acids and water soluble polysaccharides content in Ganoderma lucidum. Int J Pharm Pharm Sci 3:38–43
Christen Y (2000) Oxidative stress and Alzheimer disease. Am J Clin Nutr 71:621S–629S
Clericuzio M, Cassino C, Corana F, Vidari G (2012) Terpenoids from Russula lepida and R. amarissima (Basidiomycota, Russulaceae). Phytochemistry 84:154–159
Corbett EL, Watt CJ, Walker N, Maher D, Williams BG, Raviglione MC, Dye C (2003) The growing burden of tuberculosis: global trends and interactions with the HIV epidemic. Arch Intern Med 163:1009–1021
Córdoba KAM, Ríos AH (2012) Biotechnological applications and potential uses of the mushroom Tramestes versicolor. Vitae, revista de la facultad de química farmacéutica 19(1):70–76
Cornillier Y, Korsia-Meffre S, Senard S (2008) Le guide des compléments alimentaires. Ed. Vidal, 294 p
Dai YC (2010) Hymenochaetaceae (Basidiomycota) in China. Fungal Divers 45:131–343
Dai H, Han XQ, Gong FY, Dong H, Tu PF, Gao XM (2012) Structure elucidation and immunological function analysis of a novel β-glucan from the fruit bodies of Polyporus umbellatus (Pers.) Fries. Glycobiology 22(12):1673–1683
Davies KJ (2000) Oxidative stress, antioxidant defenses, and damage removal, repair, and replacement systems. IUBMB Life 50(4–5):279–289
De Clercq E, Field HJ (2006) Antiviral prodrugs—the development of successful prodrug strategies for antiviral chemotherapy. Br J Pharmacol 147:1–11
De Silva DD, Rapior S, Fons F, Bahkali AH, Hyde KD (2012a) Medicinal mushrooms in supportive cancer therapies: an approach to anti-cancer effects and putative mechanisms of action—a review. Fungal Divers 55:1–35
De Silva DD, Rapior S, Hyde KD, Bahkali AH (2012b) Medicinal mushrooms in prevention and control of diabetes mellitus—a review. Fungal Divers 56:1–29
Debbab A, Aly AH, Proksch P (2011) Bioactive secondary metabolites from endophytes and associated marine derived fungi. Fungal Divers 49:1–12
Debbab A, Aly AH, Proksch P (2012) Endophytes and associated marine derived fungi—ecological and chemical perspectives. Fungal Divers 57:45–83
DeChristopher BA, Loy BA, Marsden MD, Schrier AJ, Zack JA, Wender PA (2012) Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitro. Nat Chem 4:705–710
Devasagayam TP, Tilak JC, Boloor KK, Sane KS, Ghaskadbi SS, Lele RD (2004) Free radicals and antioxidants in human health: current status and future prospects. J Assoc Phys India 52:794–804
Deyrup ST, Gloer JB, O’Donnell K, Wicklow DT (2007) Kolokosides A-D: triterpenoid glycosides from a Hawaiian isolate of Xylaria sp. J Nat Prod 70(3):378–382
Ding Z, Wang W, Wang F, Wang Q, Zhang K (2012) Polysaccharides production by submerged fermentation of Coprinus comatus and their inhibitory effects on non-enzymatic glycosylation. J Med Plants Res 6:1375–1381
Dings RPM, Laar ESV, Webber J, Zhang Y, Griffin RJ, Waters SJ, MacDonald JR, Mayo KH (2008) Ovarian tumor growth regression using a combination of vascular targeting agents anginex or topomimetic 0118 and the chemotherapeutic irofulven. Cancer Lett 265:270–280
Duyckaerts C, Delatour B, Potier MC (2009) Classification and basic pathology of Alzheimer’s disease. Acta Neuropathol 118:5–36
Eckel RH, Kahn R, Robertson RM, Rizza RA (2006) Preventing cardiovascular disease and diabetes: a call to action from the American diabetes association and the american heart association. Diabetes Care 29(7):1697–1699
El Dine RS, El Halawany AM, Ma C-M, Hattori M (2008) Anti-HIV-1 protease activity of lanostane triterpenes from the vietnamese mushroom Ganoderma colossum. J Nat Prod 71:1022–1026
Engels B, Heinig U, Grothe T, Stadler M, Jennewein S (2011) Cloning and characterization of an Armillaria gallica cDNA encoding protoilludene synthase, which catalyzes the first committed step in the synthesis of antimicrobial melleolides. J Biol Chem 286:6871–6878
Enman J, Rova U, Berglund KA (2007) Quantification of the bioactive compound eritadenine in selected strains of shiitake mushroom (Lentinus edodes). J Agric Food Chem 55(4):1177–1180
Enman J, Hodge D, Berglund KA, Rova U (2008) Production of the bioactive compound eritadenine by submerged cultivation of shiitake (Lentinus edodes) mycelia. J Agric Food Chem 56(8):2609–2612
Enman J, Hodge D, Berglund KA, Rova U (2012) Growth promotive conditions for enhanced eritadenine production during submerged cultivation of Lentinus edodes. J Chem Technol Biotechnol 87(7):903–907
Erkel G, Anke T (2008) Products from Basidiomycetes? Chapter 11. Biotechnology set, 2nd edn. Wiley, New York, pp 490–526
Eussen SRBM, Verhagen H, Klungel OF, Garssen J, van Loveren H, van Kranen HJ, Rompelberg CJ (2011) Functional foods and dietary supplements: products at the interface between pharma and nutrition. Eur J Pharmacol 668:S2–S9
Fang YZ, Yang S, Wu G (2002) Free radicals, antioxidants, and nutrition. Nutrition 18(10):872–879
Fatmawati S, Shimizu K, Kondo R (2011) Ganoderol B: A potent α-glucosidase inhibitor isolated from the fruiting body of Ganoderma lucidum. Phytomedicine 18(12):1053–1055
Ferreira IC, Barros L, Abreu RM (2009) Antioxidants in wild mushrooms. Curr Med Chem 16(12):1543–1560
Ferreira ICFR, Vaz JA, Vasconcelos MH, Martins A (2010) Compounds from wild mushrooms with antitumor potential. Anticancer Agents Med Chem 10:424–436
Fisher K, Phillips C (2009) The ecology, epidemiology and virulence of Enterococcus. Microbiology 155:1749–1757
Fortes RC, Carvalho Garbi Novaes MR (2011) The effects of Agaricus sylvaticus fungi dietary supplementation on the metabolism and blood pressure of patients with colorectal cancer during post surgical phase. Nutr Hosp 26:176–186
Fortes RC, Recôva VL, Melo AL, Novaes MRCG (2008) Effects of dietary supplementation with medicinal fungus in fasting glycemia levels of patients with colorectal cancer: a randomized, double-blind, placebo-controlled clinical study. Nutr Hosp 23:591–598
Fortes RC, Novaes MRCG, Recôva VL, Melo AL (2009) Immunological, hematological, and glycemia effects of dietary supplementation with Agaricus sylvaticus on patients’ colorectal cancer. Exp Biol Med 234(1):53–62
Foster HD (2007) A role for the antioxidant defense system in preventing the transmission of HIV. Med Hypotheses 69:1277–1280
Francia C, Rapior S, Courtecuisse R, Siroux Y (1999) Current research findings on the effects of selected mushrooms on cardiovascular diseases. Int J Med Mushrooms 1:169–172
Francia C, Fons F, Poucheret P, Rapior S (2007) Activités biologiques des champignons: utilisations en médecine traditionnelle. Ann Soc Hort Histoire Nat Hérault 147:77–88
Franks LM (1997) Prostatic cancer: future prospects for diagnosis and screening. Brit J Urol 79:107–108
Gallo A, Ferrara M, Perrone G (2013) Phylogenetic study of polyketide synthases and nonribosomal peptide synthetases involved in the biosynthesis of mycotoxins. Toxins 5:717–742
Gamo FJ, Sanz LM, Vidal J, de Cozar C, Alvarez E, Lavandera JL, Vanderwall DE, Green DVS, Kumar V, Hasan S, Brown JR, Peishoff CE, Cardon LR, Garcia-Bustos JF (2010) Thousands of chemical starting points for antimalarial lead identification. Nature 465:305–310
Gazzani G, Daglia M, Papetti A (2011) Food components with anticaries activity. Curr Opin Biotechnol 23:153–159
Ghaly IS, Ahmed ES, Booles HF, Farag IM, Nada SA (2011) Evaluation of antihyperglycemic action of oyster mushroom (Pleurotus ostreatus) and its effect on DNA damage, chromosome aberrations and sperm abnormalities in streptozotocin-induced diabetic rats. Global Vet 7(6):532–544
Gilardoni G, Clericuzio M, Tosi S, Zanoni G, Vidari G (2007) Antifungal acylcyclopentenediones from fruiting bodies of Hygrophorus chrysodon. J Nat Prod 70(1):137–139
Gill M, Steglich W (1987) Progress in the chemistry of organic natural products. Fortschr Chem Org Naturst 51:88–99
Ginsberg AM (2010) Drugs in development for tuberculosis. Drugs 70(17):2201–2214
Gregerson LN, McMorris TC, Siegel JS, Baldridge KK (2003) Ab initio structure/reactivity investigations of illudin-based antitumor agents: a model for reaction in vivo. Helvet Chim Acta 86(12):4133–4151
Guillamón E, Garcia-Lafuente A, Lozano M, Moro C, Palacios I, D’Arrigo M, Martinez JA, Villares A (2011) Mushroom proteins potential therapeutic agents. Agro Food Industry Hi-Tech 22:42–44
Gunde-Cimerman N (1999) Medicinal value of the genus Pleurotus (Fr.) P. Karst. (Agaricales S.I., Basidiomycetes). Int J Med Mushrooms 1:69–80
Gunde-Cimerman N, Plemenitas A (2001) Hypocholesterolemic activity of the genus Pleurotus (Fr.) Karst. (Agaricales s.l., Basidiomycetes). Int J Med Mushrooms 3(4):395–397
Guo H, Sun B, Gao H, Chen X, Liu S, Yao X, Liu X, Che Y (2009) Diketopiperazines from the Cordyceps-colonizing fungus Epicoccum nigrum. J Nat Prod 72(12):2115–2119
Hagopian WA, Erlich H, Lernmark A, Rewers M, Ziegler AG, Simell O, Akolkar B, Vogt R, Ilonen J (2011) The environmental determinants of diabetes in the young (TEDDY): genetic criteria and international diabetes risk screening of 421 000 infants. Pediatr Diabetes 12:733–743
Halliwell B (2006) Reactive species and antioxidants: redox biology is a fundamental theme of aerobic life special issue on reactive oxygen species. Plant Physiol 41(2):312–322
Halliwell B (2012) Free radicals and antioxidants: updating a personal view. Nutr Rev 70(5):257–265
Hamedi A, Ghanati F, Vahidi H (2012) Study on the effects of different culture conditions on the morphology of Agaricus blazei and the relationship between morphology and biomass or EPS production. Ann Microbiol 62(2):699–707
Han SB, Lee CW, Kang JS, Yoon YD, Lee KH, Lee K, Park SK, Kim HM (2006) Acidic polysaccharide from Phellinus linteus inhibits melanoma cell metastasis by blocking cell adhesion and invasion. Int Immunopharmacol 6:697–702
Handa N, Yamada T, Tanaka R (2010) An unusual lanostane-type triterpenoid, spiroinonotsuoxodiol, and other triterpenoids from Inonotus obliquus. Phytochemistry 71(14–15):1774–1779
Hansen BG, Genee HJ, Kaas CS, Nielsen JB, Regueira TB, Mortensen UH, Frisvad JC, Patil KR (2011) A new class of IMP dehydrogenase with a role in self-resistance of mycophenolic acid producing fungi. BMC Microbiol 11:202. doi:10.1186/1471-2180-11-202
Hansen MB, Jensen ML, Carstensen B (2012) Causes of death among diabetic patients in Denmark. Diabetologia 55:294–302
Hao M, Head WS, Gunawardana SC, Hasty AH, Piston DW (2007) Direct effect of cholesterol on insulin secretion; a novel mechanism for pancreatic β-cell dysfunction. Diabetes 56:2328–2338
Harikrishnan R, Balasundaram C, Heo MS (2011) Diet enriched with mushroom Phellinus linteus extract enhances the growth, innate immune response, and disease resistance of kelp grouper, Epinephelus bruneus against vibriosis. Fish Shellfish Immunol 30(1):128–134
Harikrishnan R, Balasundaram C, Heo MS (2012) Effect of Inonotus obliquus enriched diet on hematology, immune response, and disease protection in kelp grouper, Epinephelus bruneus against Vibrio harveyi. Aquaculture 344–349:48–53
Hasan SS, Ahmed SI, Bukhari NI, Loon WC (2009) Use of complementary and alternative medicine among patients with chronic diseases at outpatient clinics. Complement Ther Clin Pract 15(3):152–157
He PX, Geng LJ, Wang JZ, Wang Z, Mao DB, Xu CP (2012) Purification, characterization and bioactivity of an extracellular polysaccharide produced from Phellinus igniarius. Ann Microbiol 62(4):1697–1707
Heleno SA, Barros L, Sousa MJ, Martins A, Santos-Buelga C, Ferreira ICFR (2011) Targeted metabolites analysis in wild Boletus species. LWT - Food Sci Technol 44(6):1343–1348
Hilgers W, Faivre S, Chieze S, Alexandre J, Lokiec F, Goldwasser F, Raymond E, Kahatt C, Taamma A, Weems G, MacDonald JR, Misset JL, Cvitkovic E (2006) A phase I and pharmacokinetic study of irofulven and cisplatin administered in a 30-min infusion every two weeks to patients with advanced solid tumors. Invest New Drugs 24:311–319
Hossain S, Hashimoto M, Choudhury EK, Alam N, Hussain S, Hasan M, Choudhury SK, Mahmud I (2003) Dietary mushroom (Pleurotus ostreatus) ameliorates atherogenic lipid in hypercholesterolaemic rats. Clin Exp Pharmacol Physiol 30(7):470–475
Hsu YL, Kuo PL, Cho CY, Ni WC, Tzeng TF, Ng LT, Kuo YH, Lin CC (2007) Antrodia cinnamomea fruiting bodies extract suppresses the invasive potential of human liver cancer cell line PLC/PRF/5 through inhibition of nuclear factor kappaB pathway. Food Chem Toxicol 45(7):1249–1257
Hu SH, Wang JC, Lien JL, Liaw ET, Lee MY (2006a) Antihyperglycemic effect of polysaccharide from fermented broth of Pleurotus citrinopileatus. Appl Microbiol Biotechnol 70:107–113
Hu SH, Liang ZC, Chia YC, Lien JL, Chen KS, Lee MY, Wang JC (2006b) Antihyperlipidemic and antioxidant effects of extracts from Pleurotus citrinopileatus. J Agric Food Chem 54:2103–2110
Huang CF (2007) Effect of Monascus purpureus went rice on lowering lipid ratios in hypercholesterolemic patients. Eur J Cardiovasc Prev Rehabil 14(3):438–440
Huang NK, Cheng JY, Lai WL, Lu MK (2005) Antrodia camphorata prevents rat pheochromocytoma cells from serum deprivation-induced apoptosis. FEMS Microbiol Lett 244(1):213–219
Huang GJ, Yang CM, Chang YS, Amagaya S, Wang HC, Hou WC, Huang SS, Hu ML (2010a) Hispolon suppresses SK-Hep1 human hepatoma cell metastasis by inhibiting matrix metalloproteinase-2/9 and urokinase-plasminogen activator through the PI3K/Akt and ERK signaling pathways. J Agric Food Chem 58(17):9468–9475
Huang WY, Cai YZ, Zhang Y (2010b) Natural phenolic compounds from medicinal herbs and dietary plants: potential use for cancer prevention. Nutr Cancer 62(1):1–20
Huang GJ, Hsieh WT, Chang HY, Huang SS, Lin YC, Kuo YH (2011) α-Glucosidase and aldose reductase inhibitory activities from the fruiting body of Phellinus merrillii. J Agric Food Chem 59:5702–5706
Hyde KD (2001) Where are the missing fungi; does Hong Kong have any answers. Mycol Res 105:1514–1518
Igel LI, Powell AG, Apovian CM, Aronne LJ (2012) Advances in medical therapy for weight loss and the weight-centric management of type 2 diabetes mellitus. Curr Atheroscler Rep 14:60–69
Isaac S (1997) Fungi naturally form many diverse biochemical products, some of which are now commercially important; how and why do they do this? Mycol Answers 11:182–183
Isaka M, Tanticharoen M, Kongsaeree P, Thebtaranonth Y (2001) Structures of cordypyridones A-D, antimalarial N-hydroxy- and N-methoxy-2-pyridones from the insect pathogenic fungus Cordyceps nipponica. J Org Chem 66(14):4803–4808
Isaka M, Srisanoh U, Lartpornmatulee N, Boonruangprapa T (2007) ES-242 derivatives and cycloheptapeptides from Cordyceps sp. strains BCC 16173 and BCC 16176. J Nat Prod 70(10):1601–1604
Isaka M, Srisanoh U, Choowong W, Boonpratuang T (2011) Sterostreins A-E, new terpenoids from cultures of the Basidiomycete Stereum ostrea BCC 22955. Org Lett 13(18):4886–4889
Isaka M, Srisanoh U, Sappan M, Supothina S, Boonpratuang T (2012) Sterostreins F-O, illudalanes and norilludalanes from cultures of the basidiomycete Stereum ostrea BCC 22955. Phytochemistry 79:116–120
Isaka M, Chinthanom P, Kongthong S, Srichomthong K, Choeyklin R (2013) Lanostane triterpenes from cultures of the Basidiomycete Ganoderma orbiforme BCC 22324. Phytochemistry 87:133–139
Iwalokun BA, Usen UA, Otunba AA, Olukoya DK (2007) Comparative phytochemical evaluation, antimicrobial and antioxidant properties of Pleurotus ostreatus. Afr J Biotechnol 6(15):1732–1739
Jakopovich I (2011) New dietary supplements from medicinal mushrooms: Dr Myko San—a registration report. Int J Med Mushrooms 13:307–313
Jang JS, Lee JS, Lee JH, Kwon DS, Lee KE, Lee SY, Hong EK (2010) Hispidin produced from Phellinus linteus protects pancreatic β-cells from damage by hydrogen peroxide. Arch Pharm Res 33:853–861
Jasinghe VJ, Perera CO, Sablani SS (2007) Kinetics of the conversion of ergosterol in edible mushrooms. J Food Eng 79:864–869
Jaturapat A, Isaka M, Hywel-Jones NL, Lertwerawat Y, Kamchonwongpaisan S, Kirtikara K, Tanticharoen M, Thebtaranonth Y (2001) Bioxanthracenes from the insect pathogenic fungus Cordyceps pesudomilitaris BCC 1620. I. Taxonomy, fermentation, isolation and antimalarial activity. J Antibiot 54:29–35
Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ (2009) Cancer statistics 2009. Cancer J Clin 59:225–249
Jeon S, Bose S, Hur J, Jun K, Kim YK, Cho KS, Koo BS (2011) A modified formulation of Chinese traditional medicine improves memory impairment and reduces Aβ level in the Tg-APPswe/PS1dE9 mouse model of Alzheimer’s disease. J Ethnopharmacol 137(1):783–789
Jeong SC, Jeong YT, Yang BK, Islam R, Koyyalamudi SR, Pang G, Cho KY, Song CH (2010) White button mushroom (Agaricus bisporus) lowers blood glucose and cholesterol levels in diabetic and hypercholesterolemic rats. Nutr Res 30(1):49–56
Jeong JW, Jin CY, Park C, Hong SH, Kim GY, Jeong YK, Lee JD, Yoo YH, Choi YH (2011) Induction of apoptosis by cordycepin via reactive oxygen species generation in human leukemia cells. Toxicol in Vitro 25:817–824
Jiang J, Sliva D (2010) Novel medicinal mushroom blend suppresses growth and invasiveness of human breast cancer cells. Int J Oncol 37(6):1529–1536
Jiang J, Grieb B, Thyagarajan A, Sliva D (2008) Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-kappaB signaling. Int J Mol Med 21(5):577–584
Jiang MY, Zhang L, Liu R, Dong ZJ, Liu JK (2009) Speciosins A-K, oxygenated cyclohexanoids from the basidiomycete Hexagonia speciosa. J Nat Prod 72(8):1405–1409
Jiang MY, Li Y, Wang F, Liu JK (2011a) Isoprenylated cyclohexanoids from the basidiomycete Hexagonia speciosa. Phytochemistry 72:923–928
Jiang Y, Wong JH, Fu M, Ng TB, Liu ZK, Wang CR, Li N, Qiao WT, Wen TY, Liu F (2011b) Isolation of adenosine, iso-sinensetin and dimethylguanosine with antioxidant and HIV-1 protease inhibiting activities from fruiting bodies of Cordyceps militaris. Phytomedicine 18(2–3):189–193
Jiang J, Thyagarajan-Sahu A, Loganathan J, Eliaz I, Terry C, Sandusky GE, Sliva D (2012) BreastDefend™ prevents breast-to-lung cancer metastases in an orthotopic animal model of triple-negative human breast cancer. Oncol Rep 28(4):1139–1145
Jin X, Ruiz Beguerie J, Sze DM, Chan GC (2012) Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane Database Syst Rev 13:6. doi:10.1002/14651858
Johansson M, Sterner O, Labischinski H, Anke T (2001) Coprinol, a new antibiotic cuparane from a Coprinus species. Z Naturforsch C 56(1–2):31–34
Jones PS (1998) Strategies for antiviral drug discovery. Antivir Chem Chemother 9:283–302
Jung JY, Lee IK, Seok SJ, Lee HJ, Kim YH, Yun BS (2008) Antioxidant polyphenols from the mycelial culture of the medicinal fungi Inonotus xeranticus and Phellinus linteus. J Appl Microbiol 104(6):1824–1832
Kabanov AS, Kosogova TA, Shishkina LN, Tepliakova TV, Skarnovich MO, Mazurkova NA, Puchkova LI, Malkova EM, Stavskiĭ EA, Drozdov IG (2011) Study of antiviral activity of extracts obtained from basidial fungi against influenza viruses of different subtypes in experiments in vitro and in vivo. Zh Mikrobiol Epidemiol Immunobiol 1:40–43
Kadomatsu M, Nakajima S, Kato H, Gu L, Chi Y, Yao J, Kitamura M (2012) Cordycepin as a sensitizer to tumour necrosis factor (TNF)-α-induced apoptosis through eukaryotic translation initiation factor 2α (eIF2α)- and mammalian target of rapamycin complex 1 (mTORC1)-mediated inhibition of nuclear factor (NF)-κB. Clin Exp Immunol 168:325–332
Kan WC, Wang HY, Chien CC, Li SL, Chen YC, Chang LH, Cheng CH, Tsai WC, Hwang JC, Su SH, Huang LH, Choo JJ (2012) Effects of extract from solid-state fermented Cordyceps sinensis on type 2 diabetes mellitus. Evid Based Complement Alternat Med. doi:10.1155/2012/743107, 10 pages
Kang HS, Jun EM, Park SH, Heo SJ, Lee TS, Yoo ID, Kim JP (2007) Cyathusals A, B, and C, antioxidants from the fermented mushroom Cyathus stercoreus. J Nat Prod 70(6):1043–1045
Kanokmedhakul S, Lekphrom R, Kanokmedhakul K, Hahnvajanawong C, Bua-art S, Saksirirat W, Prabpai S, Kongsaeree P (2012) Cytotoxic sesquiterpenes from luminescent mushroom Neonothopanus nimbi. Tetrahedron 68:8261–8266
Katsayal UA, Abdurahman EM, Abubakar MS, Musa KY, Ambali SF, Jahun MB (2009) Fungi as potential source of antimalarial agents. Niger J Pharm Sci 8(1):135–142
Kaur J, Singh P, Sowers JR (2002) Diabetes and cardiovascular diseases. Am J Ther 9:510–515
Kaur K, Jain M, Kaur T, Jain R (2009) Antimalarials from nature. Bioorg Med Chem 17:3229–3256
Kawagishi H (2010) Biologically functional molecules from mushrooms. J Synth Org Chem Jpn 68(5):514–521
Kawagishi H, Zhuang C (2008) Compounds for dementia from Hericium erinaceum. Drugs Fut 33(2):149. doi:10.1358/dof.2008.033.02.1173290
Kawagishi H, Shimada A, Shirai R, Okamoto K, Ojima F, Sakamoto H, Ishiguro Y, Furukawa S (1994) Hericenones A, B, C, strong stimulators of nerve growth factor synthesis, from the mycelia of Hericium erinaceus. Tetrahedr Lett 35:1569–1572
Keller C, Maillard M, Keller J, Hostettmann K (2002) Screening of European fungi for antibacterial, antifungal, larvicidal, molluscicidal, antioxidant and free radical scavenging activities and subsequent isolation of bioactive compounds. Pharm Biol 40:518–525
Kelner MJ, McMorris TC, Rojas RJ, Estes LA, Suthipinijtham P (2008) Synergy of irofulven in combination with other DNA damaging agents: synergistic interaction with altretamine, alkylating, and platinum-derived agents in the MV522 lung tumor model. Cancer Chemother Pharm 63:19–26
Kettering M, Valdivia C, Sterner O, Anke H, Thines E (2005) Heptemerones A G, seven novel diterpenoids from Coprinus heptemerus: producing organism, fermentation, isolation and biological activities. J Antibiot 58:390–396
Khan MA, Tania M (2012) Nutritional and medicinal importance of pleurotus mushrooms: an overview. Food Rev Intern 28(3):313–329
Khan TK, Nelson TJ, Verma VA, Wender PA, Alkon DL (2009) A cellular model of Alzheimer’s disease therapeutic efficacy: PKC activation reverses Aβ-induced biomarker abnormality on cultured fibroblasts. Neurobiol Dis 34(2):332–339
Khan MA, Tania M, Zhang DZ, Chen HC (2010) Cordyceps mushroom: a potent anticancer nutraceutical. Open Nutraceuticals J 3:179–183
Khatun K, Mahtab H, Khanam PA, Sayeed MA, Khan KA (2007) Oyster mushroom reduced blood glucose and cholesterol in diabetic subjects. Mymensingh Med J 16:94–99
Kidd PM (2000) The use of mushroom glucans and proteoglycans in cancer treatment. Altern Med Rev 5:4–27
Kim YO, Park HW, Kim JH, Lee JY, Moon SH, Shin CS (2006) Anticancer effect and structural characterization of endo-polysaccharide from cultivated mycelia of Inonotus obliquus. Life Sci 79:72–80
Kim YJ, Park J, Min BS, Shim SH (2011) Chemical constituents from the sclerotia of Inonotus obliquus. J Korean Soc Appl Biol Chem 54(2):287–294
Kim SP, Moon E, Nam SH, Friedman M (2012) Hericium erinaceus mushroom extracts protect infected mice against Salmonella typhimurium-induced liver damage and mortality by stimulation of innate immune cells. J Agric Food Chem 60(22):5590–5596
Kinge TR, Mih AM (2011) Secondary metabolites of oil palm isolates of Ganoderma zonatum Murill. from Cameroon and their cytotoxicity against five human tumour cell lines. Afr J Biotechnol 10(42):8440–8447
Kittakoop P, Punya J, Kongsaeree P, Lertwerawat Y, Jintasirikul A, Tanticharoen M, Thebtaranonth Y (1999) Bioactive naphthoquinones from Cordyceps unilateralis. Phytochemistry 52:453–457
Klein E, Smith DL, Laxminarayan R (2007) Hospitalizations and deaths caused by methicillin-resistant Staphylococcus aureus, United States, 1999–2005. Emerg Infect Dis 13(12):1840–1846
Kleinwächter P, Anh N, Kiet TT, Schlegel B, Dahse HM, Härtl A, Gräfe U (2001) Colossolactones, new triterpene metabolites from a Vietnamese mushroom Ganoderma colossum. J Nat Prod 64:236–239
Kollerov VV, Shutov AA, Fokina VV, Sukhodol’skaia GV, Gulevskaia SA, Donova MV (2010) Bioconversion of C19- and C21-steroids with parent and mutant strains of Curvularia lunata. Prikl Biokhim Mikrobiol 46(2):212–220
Kozlovskii AG, Zhelifonova VP, Antipova TV (2013) Fungi of the genus Penicillium as producers of physiologically active compounds (review). Appl Biochem Microb 49(1):1–10
Kregel KC, Zhang HJ (2007) An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations. Am J Physiol Regul Integr Comp Physiol 292(1):R18–R36
Krettli AU (2009) Antimalarial drug discovery: screening of Brazilian medicinal plants and purified compounds. Expert Opin Drug Discov 4:95–108
Krishnaiah D, Sarbatly R, Nithyanandam R (2010) A review of the antioxidant potential of medicinal plant species. Food Bioprod Process 89(3):217–233
Kuiken T, Fouchier R, Rimmelzwaan G, Osterhaus A (2003) Emerging viral infections in a rapidly changing world. Curr Opin Biotechnol 14(6):641–646
Kulangara C, Luedin S, Dietz O, Rusch S, Frank G, Mueller D, Moser M, Kajava AV, Corradin G, Beck HP, Felger I (2012) Cell biological characterization of the malaria vaccine candidate trophozoite exported protein 1. PLoS One 7(10):e46112
Kuller LH (2006) Prevention of coronary heart disease and the national cholesterol education program. Circulation 113:598–600
Kumaran RS, Muthumary J, Hur BK (2008) Taxol from Phyllosticta citricarpa, a leaf spot fungus of the angiosperm Citrus medica. J Biosci Bioeng 106(1):103–106
Lam WP, Wang CM, Tsui TY, Wai MS, Tang HC, Wong YW, Lam LH, Hui LK, Yew DT (2012) Extract of white button mushroom affects skin healing and angiogenesis. Microsc Res Tech 75(10):1334–1340
Lau CC, Abdullah N, Shuib AS, Aminudin N (2012) Proteomic analysis of antihypertensive proteins in edible mushrooms. J Agric Food Chem 60(50):12341–12348
Leal AR, Barros L, Barreira JCM, Sousa MJ, Martinsa A, Santos-Buelga C, Ferreira ICFR (2013) Portuguese wild mushrooms at the “pharma–nutrition” interface: nutritional characterization and antioxidant properties. Food Res Intern 50:1–9
Lee JS, Hong EK (2011) Immunostimulating activity of the polysaccharides isolated from Cordyceps militaris. Int Immunopharmacol 11:1226–1233
Lee IK, Yun BS (2006) Hispidin analogs from the mushroom Inonotus xeranticus and their free radical scavenging activity. Bioorg Med Chem Lett 16(9):2376–2379
Lee IK, Yun BS (2007) Highly oxygenated and unsaturated metabolites providing a diversity of hispidin class antioxidants in the medicinal mushrooms Inonotus and Phellinus. Bioorg Med Chem 15(10):3309–3314
Lee IK, Yun BS (2011) Styrylpyrone-class compounds from medicinal fungi Phellinus and Inonotus spp., and their medicinal importance. J Antibiot 64:349–359
Lee IK, Seok SJ, Kim WK, Yun BS (2006) Hispidin derivatives from the mushroom Inonotus xeranticus and their antioxidant activity. J Nat Prod 69(2):299–301
Lee WY, Park Y, Ahn JK, Ka KH, Park SY (2007a) Factors influencing the production of endopolysaccharide and exopolysaccharide from Ganoderma applanatum. Enzym Microb Technol 40:249–254
Lee IK, Kim YS, Jang YW, Jung JY, Yun BS (2007b) New antioxidant polyphenols from the medicinal mushroom Inonotus obliquus. Bioorg Med Chem Lett 17(24):6678–6681
Lee IK, Kim YS, Seok SJ, Yun BS (2007c) Inoscavin E, a free radical scavenger from the fruiting bodies of Inonotus xeranticus. J Antibiot (Tokyo) 60(12):745–747
Lee YS, Kang YH, Jung JY, Kang IJ, Han SN, Chung JS, Shin HK, Lim SS (2008a) Inhibitory constituents of aldose reductase in the fruiting body of Phellinus linteus. Biol Pharm Bull 31(4):765–768
Lee YG, Lee WM, Kim JY, Lee JY, Lee IK, Yun BS, Rhee MH, Cho JY (2008b) Src kinase-targeted anti-inflammatory activity of davallialactone from Inonotus xeranticus in lipopolysaccharide-activated RAW264.7 cells. Br J Pharmacol 154(4):852–863
Lee YS, Kang IJ, Won MH, Lee JY, Kim JK, Lim SS (2010) Inhibition of protein tyrosine phosphatase 1beta by hispidin derivatives isolated from the fruiting body of Phellinus linteus. Nat Prod Commun 5(12):1927–1930
Lee IK, Jung JY, Yeom JH, Ki DW, Lee MS, Yeo WH, Yun BS (2012) Fomitoside K, a new lanostane triterpene glycoside from the fruiting body of Fomitopsis nigra. Mycobiology 40(1):76–78
Leggas M, Stewart CF, Woo MH, Fouladi M, Cheshre PJ, Peterson JK, Friedman HS, Billups C, Houghton PJ (2002) Relation between Irofulven (MGI-114) systemic exposure and tumor response in human solid tumor xenografts. Clin Cancer Res 8:3000–3007
Lemieszek MK, Langner E, Kaczor J, Kandefer-Szerszeń M, Sanecka B, Mazurkiewicz W, Rzeski W (2011) Anticancer effects of fraction isolated from fruiting bodies of Chaga medicinal mushroom, Inonotus obliquus (Pers.:Fr.) Pilát (Aphyllophoromycetideae): in vitro studies. Int J Med Mushrooms 13(2):131–143
Leung MYK, Liu C, Koon JCM, Fung KP (2006) Polysaccharide biological response modifiers. Immunol Lett 105:101–111
Li JWH, Vederas JC (2009) Drug discovery and natural products: end of an era or an endless frontier. Science 325:161–165
Li N, Li L, Fang JC, Wong JH, Ng TB, Jiang Y, Wang CR, Zhang NY, Wen TY, Qu LY, Lv PY, Zhao R, Shi B, Wang YP, Wang XY, Liu F (2011) Isolation and identification of a novel polysaccharidepeptide complex with antioxidant, antiproliferative and hypoglycaemic activities from the abalone mushroom. Biosci Rep 32(3):221–228
Li N, Li L, Fang JC, Wong JH, Ng TB, Jiang Y, Wang CR, Zhang NY, Wen TY, Qu LY, Lv PY, Zhao R, Shi B, Wang YP, Wang XY, Liu F (2012) Isolation and identification of a novel polysaccharide-peptide complex with antioxidant, anti-proliferative and hypoglycaemic activities from the abalone mushroom. Biosci Rep 32(3):221–228
Li YB, Liu RM, Zhong JJ (2013) A new ganoderic acid from Ganoderma lucidum mycelia and its stability. Fitoterapia 84:115–122
Lima CU, Souza VC, Morita MC, Chiarello MD, Karnikowski MG (2012) Agaricus blazei Murrill and inflammatory mediators in elderly women: a randomized clinical trial. Scand J Immunol 75(3):336–341
Lin SB, Li CH, Lee SS, Kan LS (2003) Triterpene-enriched extracts from Ganoderma lucidum inhibit growth of hepatoma cells via suppressing protein kinase C, activating mitogen-activated protein kinases and G2-phase cell cycle arrest. Life Sci 72:2381–2390
Lindequist U, Niedermeyer THJ, Jülich WD (2005) The pharmacological potential of mushrooms. Evid Based Complement Alternat Med 2:285–299
Lindequist U, Rausch R, Füssel A, Hanssen HP (2010) Higher fungi in traditional and modern medicine. Med Monatsschr Pharm 33:40–48
Liu J (2002) Biologically active substances from mushrooms in Yunnan, China. Heterocycles 57:157–167
Liu JK (2007) Secondary metabolites from higher fungi in China and their biological activity. Drug Discov Ther 1:94–103
Liu XT, Winkler AL, Schwan WR, Volk TJ, Rott M, Monte A (2010a) Antibacterial compounds from mushrooms II: lanostane triterpenoids and an ergostane steroid with activity against Bacillus cereus isolated from Fomitopsis pinicola. Planta Med 76(5):464–466
Liu XT, Winkler AL, Schwan WR, Volk TJ, Rott MA, Monte A (2010b) Antibacterial compounds from mushrooms I: a lanostane-type triterpene and prenylphenol derivatives from Jahnoporus hirtus and Albatrellus flettii and their activities against Bacillus cereus and Enterococcus faecalis. Planta Med 76(2):182–185
Liu YJ, Shen J, Xia YM, Zhang J, Park HS (2012a) The polysaccharides from Ganoderma lucidum: are they always inhibitors on human hepatocarcinoma cells? Carbohydr Polym 90(3):1210–1215
Liu GQ, Wang XL, Han WJ, Lin QL (2012b) Improving the fermentation production of the individual key triterpene ganoderic acid Me by the medicinal fungus Ganoderma lucidum in submerged culture. Molecules 17:12575–12586
Liu RM, Li YB, Zhong JJ (2012c) Cytotoxic and pro-apoptotic effects of novel ganoderic acid derivatives on human cervical cancer cells in vitro. Eur J Pharmacol 681(1–3):23–33
Liu J, Shimizu K, Tanaka A, Shinobu W, Ohnuki K, Nakamura T, Kondo R (2012d) Target proteins of ganoderic acid DM provides clues to various pharmacological mechanisms. Sci Rep 2:905. doi:10.1038/srep00905
Liu L, Shi XW, Zong SC, Tang JJ, Gao JM (2012e) Scabronine M, a novel inhibitor of NGF-induced neurite outgrowth from PC12 cells from the fungus Sarcodon scabrosus. Bioorg Med Chem Lett 22(7):2401–2406
Liu Y, Kubo M, Fukuyama Y (2012f) Nerve growth factor-potentiating benzofuran derivatives from the medicinal fungus Phellinus ribis. J Nat Prod 75(12):2152–2157
Lu MK, Cheng JJ, Lai WL, Lin YJ, Huang NK (2008) Fermented Antrodia cinnamomea extract protects rat PC12 cells from serum deprivation-induced apoptosis: the role of the MAPK family. J Agric Food Chem 56(3):865–874
Lu TL, Huang GJ, Lu TJ, Wu JB, Wu CH, Yang TC, Iizuka A, Chen YF (2009) Hispolon from Phellinus linteus has antiproliferative effects via MDM2-recruited ERK1/2 activity in breast and bladder cancer cells. Food Chem Toxicol 47:2013–2021
Lu X, Chen H, Dong P, Fu L, Zhang X (2010) Phytochemical characteristics and hypoglycaemic activity of fraction from mushroom Inonotus obliquus. J Sci Food Agric 90(2):276–280
Lung MY, Hsieh CW (2011) Antioxidant property and production of exopolysaccharide from Armillaria mellea in submerged cultures: effect of culture aeration rate. Eng Life Sci 11(5):482–490
Lynch T, Cherny RA, Bush AI (2000) Oxidative processes in Alzheimer’s disease: the role of a metal interactions. Exp Gerontol 35:45–451
Ma BJ, Shen JW, Yu HY, Ruan Y, Wu TT, Zhao X (2010) Hericenones and erinacines: stimulators of nerve growth factor (NGF) biosynthesis in Hericium erinaceus. Mycol Int J Fungal Biol 1(2):92–98
Mabinya LV, Mafunga T, Brand JM (2010) Bioconversion of ferulic acid and 4-vinylguaiacol by a white-rot fungus isolated from decaying wood. Afr J Biotechnol 9(13):1955–1958
Mahdy Ali K, Wonnerth A, Huber K, Wojta J (2012) Cardiovascular disease risk reduction by raising HDL cholesterol-current therapies and future opportunities. Br J Pharmacol 167(6):1177–1194
Maia SC, Toledo RC, Almeida AP, da Silva R, Rinker DL, Dias ES (2012) Low-cost and low maintenance preservation of Agaricus brasiliensis cultures. World J Microbiol Biotechnol 28(6):2411–2416
Maity K, Samanta S, Bhanja SK, Maity S, Sen IK, Maiti S, Behera B, Maiti TK, Sikdar SR, Islam SS (2012) An immunostimulating water insoluble β-glucan of an edible hybrid mushroom: isolation and characterization. Fitoterapia 84C:15–21
Malinowska E, Krzyczkowski W, Łapienis G, Herold F (2009) Improved simultaneous production of mycelial biomass and polysaccharides by submerged culture of Hericium erinaceum: optimization using a central composite rotatable design (CCRD). J Ind Microbiol Biotechnol 36(12):1513–1527
Mallery SR, Clark YM, Ness GM, Minshawi OM, Pei P, Hohl CM (1999) Thiol redox modulation of doxorubicin mediated cytotoxicity in cultured AIDS-related Kaposi’s sarcoma cells. J Cell Biochem 73:259–277
Mangialasche F, Solomon A, Winblad B, Mecocci P, Kivipelto M (2010) Alzheimer’s disease: clinical trials and drug development. Lancet Neurol 9:702–716
Marcotullio MC, Pagiotti R, Maltese F, Obara Y, Hoshino T, Nakahata N, Curini M (2006) Neurite outgrowth activity of cyathane diterpenes from Sarcodon cyrneus, cyrneines A and B. Planta Med 72(9):819–823
Mathé D (1995) Dyslipidemia and diabetes: animal models. Diabete Metab 21(2):106–111
Mattila P, Kanko K, Earola M, Pihlava JM, Astola J, Vahterist L (2001) Contents of vitamins, mineral elements, some phenolic compounds in cultivated mushrooms. J Agric Food Chem 49:2343–2348
Mattila P, Salo-Väänänen P, Könkö K, Aro H, Jalava T (2002) Basic composition and amino acid contents of mushrooms cultivated in Finland. J Agric Food Chem 50:6419–6422
Mattill HA (1947) Antioxidants. Annu Rev Biochem 16:177–192
McMorris TC (1999) Discovery and development of sesquiterpenoid derived hydroxymethylacylfulvene: a new anticancer drug. Bioorg Med Chem 7:881–886
McMorris TC, Kelner MJ, Wang W, Yu J, Estes LA, Taetle R (1996) (Hydroxymethyl) acylfulvene: an illudin derivative with superior antitumor properties. J Nat Prod 59:896–899
Mendis K, Rietveld A, Warsame M, Bosman A, Greenwood B, Wernsdorfer WH (2009) From malaria control to eradication: the WHO perspective. Trop Med Int Health 14:802–809
Merican I, Guan R, Amarapuka D, Alexander MJ, Chutaputti A, Chien RN, Hasnian SS, Leung N, Lesmana L, Phiet PH, Sjalfoellah Noer HM, Sollano J, Sun HS, Xu DZ (2000) Chronic hepatitis B virus infection in Asian countries. J Gastroenterol Hepatol 15(12):1356–1361
Min BS, Nakamura N, Miyashiro H, Bae KW, Hattori M (1998) Triterpenes from the spores of Ganoderma lucidum and their activity against HIV-1 protease. Chem Pharm Bull 46(10):1607–1612
Misiek M, Hoffmeister D (2012) Sesquiterpene aryl ester natural products in North American Armillaria species. Mycol Prog 11:7–15
Misiek M, Williams J, Schmich K, Hüttel W, Merfort I, Salomon C, Aldrich CA, Hoffmeister D (2009) Structure and cytotoxicity of Arnamial and related fungal sesquiterpene aryl esters. J Nat Prod 72:1888–1891
Mo S, Wang S, Zhou G, Yang Y, Li Y, Chen X, Shi J (2004) Phelligridins C-F: cytotoxic pyrano[4,3-c][2]benzopyran-1,6-dione and furo[3,2-c]pyran-4-one derivatives from the fungus Phellinus igniarius. J Nat Prod 67:823–828
Mohsin M, Negi P, Ahmed Z (2011) Determination of the antioxidant activity and polyphenol contents of wild Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (W.Curt. Fr.) P. Karst. (Higher Basidiomycetes) from central Himalayan hills of India. Int J Med Mushrooms 13(6):535–544
Moldavan MG, Gryganski AP, Kolotushkina OV, Kirchhoff B, Skibo GG, Pedarzani P (2007) Neurotropic and trophic action of lion’s mane mushroom Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) extracts on nerve cells in vitro. Int J Med Mushrooms 9(1):15–28
Moran GP, Pinjon E, Coleman DC, Sullivan DJ (2007) Analysis of drug resistance in pathogenic fungi. In: Kavanagh K (ed) Medical mycology: cellular and molecular techniques. Wiley, Chichester, pp 93–113
Mori K, Obara Y, Hirota M, Azumi Y, Kinugasa S, Inatomi S, Nakahata N (2008) Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. Biol Pharm Bull 31(9):1727–1732
Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T (2009) Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res 23(3):367–372
Mortimer PE, Karunarathna SC, Li QH, Gui H, Yang XQ, Yang XF, He J, Ye L, Guo JY, Li HL, Sysouphanthong P, Zhou DQ, Xu JC, Hyde KD (2012) Prized edible Asian mushrooms: ecology, conservation and sustainability. Fungal Divers 56(1):31–47
Mothana RA, Jansen R, Jülich WD, Lindequist U (2000) Ganomycins A and B, new antimicrobial farnesyl hydroquinones from the basidiomycete Ganoderma pfeifferi. J Nat Prod 63(3):416–418
Mothana RAA, Awadh NAA, Jansen R, Wegner U, Mentel R, Lindequist U (2003) Antiviral lanostanoid triterpenes from the fungus Ganoderma pfeifferi Bres. Fitoterapia 74:177–180
Mulac D, Huwel S, Galla HJ, Humpf HU (2012) Permeability of ergot alkaloids across the blood–brain barrier in vitro and influence on the barrier integrity. Mol Nutr Food Res 56(3):475–485
Mygind PH, Fischer RL, Schnorr KM, Hansen MT, Sönksen CP, Ludvigsen S, Raventós D, Buskov S, Christensen B, De Maria L, Taboureau O, Yaver D, Elvig-Jørgensen SG, Sørensen MV, Christensen BE, Kjærulff S, Frimodt-Moller N, Lehrer RI, Zasloff M, Kristensen HH (2005) Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus. Nature 437:975–980
Nagabushan H (2010) Retapamulin: a novel topical antibiotic. Indian J Dermatol Venereol Leprol (IJDVL) 76(1):77–79
Nagai K, Chiba A, Nishino T, Kubota T, Kawagishi H (2006) Dilinoleoyl-phosphatidylethanolamine from Hericium erinaceum protects against ER stress-dependent Neuro2a cell death via protein kinase C pathway. J Nutr Biochem 17:525–530
Nagy IZ (2001) On the true role of oxygen free radicals in the living state, aging, and degenerative disorders. Ann N Y Acad Sci 928:187–199
Nakajima Y, Nishida H, Matsugo S, Konishi T (2009) Cancer cell cytotoxicity of extracts and small phenolic compounds from Chaga [Inonotus obliquus (Persoon) Pilat]. J Med Food 12:501–507
Nakata T, Yamada T, Taji S, Ohishi H, Wada S, Tokuda H, Sakuma K, Tanaka R (2007) Structure determination of inonotsuoxides A and B and in vivo antitumor promoting activity of inotodiol from the sclerotia of Inonotus obliquus. Bioorg Med Chem 15:257–264
NCI (2006) National cancer institute. Biological therapies for cancer. Questions and answers. http://www.cancer.gov/cancertopics/factsheet/Therapy/biological
NCI (2011) National cancer institute. Cancer topics http://www.cancer.gov/cancertopics/cancerlibrary/what-is-cancer
Newman DJ, Cragg GM (2007) Natural products as sources of new drugs over the last 25 years. J Nat Prod 70(3):461–477
Ng TB, Huang B, Fong WP, Yeung HW (1997) Anti-human immunodeficiency virus (anti-HIV) natural products with special emphasis on HIV reverse transcriptase inhibitors. Life Sci 61:933–949
Ngai PH, Ng TB (2003) Lentin, a novel and potent antifungal protein from shitake mushroom with inhibitory effects on activity of human immunodeficiency virus-1 reverse transcriptase and proliferation of leukemia cells. Life Sci 73(26):3363–3374
Nguyen HN, Wang TC, Lin TA, Guo JH (2012) Optimal conditions for mycelia biomass and extracellular polysaccharides of Grifola frondosa: effect of agitation speed, inoculum ratio and initial pH. Afr J Biotechnol 11(23):6317–6326
Nogueira CR, Lopes LMX (2011) Antiplasmodial natural products. Molecules 16:2146–2190
Nomura M, Takahashi T, Uesugi A, Tanaka R, Kobayashi S (2008) Inotodiol, a lanostane triterpenoid, from Inonotus obliquus inhibits cell proliferation through caspase-3-dependent apoptosis. Anticancer Res 28(5A):2691–2696
Nonaka Y, Ishibashi H, Nakai M, Shibata H, Kiso Y, Abe S (2008) Effects of the antlered form of Ganoderma lucidum on tumor growth and metastasis in cyclophosphamide-treated mice. Biosci Biotechnol Biochem 72(6):1399–1408
Novak R, Shlaes DM (2010) The pleuromutilin antibiotics: a new class for human use. Curr Opin Investig Drugs 11(2):182–191
Nowell PC (1986) Mechanisms of tumor progression. Cancer Res 46:2203–2207
Ntougias S, Baldrian P, Ehaliotis C, Nerud F, Antoniou T, Merhautová V, Zervakis GI (2012) Biodegradation and detoxification of olive mill wastewater by selected strains of the mushroom genera Ganoderma and Pleurotus. Chemosphere 88(5):620–626
Obara Y, Hoshino T, Marcotullio MC, Pagiotti R, Nakahata N (2007) Novel cyathane diterpene, cyrneine A, induces neurite outgrowth in a Rac1-dependent mechanism in PC12 cells. Life Sci 80(18):1669–1677
Oboh G, Shodehinde SA (2009) Distribution of nutrients, polyphenols and antioxidant activities in the pilei and stipes of some commonly consumed edible mushrooms in Nigeria. Bull Chem Soc Ethiop 23(3):391–398
Ochoa-Zarzosa A, Vázquez-Garcidueñas MS, Robinson-Fuentes VA, Vázquez-Marrufo G (2011) Antibacterial and cytotoxic activity from basidiocarp extracts of the edible mushroom Lactarius indigo (Schw.) Fr. (Russulaceae). Afr J Pharm Pharmacol 5(2):281–288
Ohtsuki M, Umeshita K, Kokean Y, Nishii T, Sakakura H, Yanagita T, Hisamatsu M, Furuichi Y (2007) Suppressive effects of bunashimeji (Hypsizigus marmoreus) on triacylglycerol accumulation in C57BL/6J mice. J Jpn Soc Food Sci Technol 54(4):167–172
Ota Y, Hattori T, Banik MT, Hagedorn G, Sotome K, Tokuda S, Abe Y (2009) The genus Laetiporus (Basidiomycota, Polyporales) in East Asia. Mycol Res 113(Pt 11):1283–1300
Ou YX, Li YY, Qian XM, Shen YM (2012) Guanacastane-type diterpenoids from Coprinus radians. Phytochemistry 78:190–196
Pan SY, Pan S, Yu ZL, Ma DL, Chen SB, Fong WF, Han YF, Ko KM (2010) New perspectives on innovative drug discovery: an overview. J Pharm Pharm Sci 13(3):450–471
Pandey KB, Rizvi SI (2009) Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev 2(5):270–278
Papaspyridi LM, Katapodis P, Gonou-Zagou Z, Kapsanaki-Gotsi E, Christakopoulos P (2011) Growth and biomass production with enhanced b-glucan and dietary fibre contents of Ganoderma australe ATHUM 4345 in a batch-stirred tank bioreactor. Eng Life Sci 11(1):65–74
Papaspyridi LM, Aligiannis N, Topakas E, Christakopoulos P, Skaltsounis AL, Fokialakis N (2012) Submerged fermentation of the edible mushroom Pleurotus ostreatus in a batch stirred tank bioreactor as a promising alternative for the effective production of bioactive metabolites. Molecules 17:2714–2724
Pasinetti GM (2012) Novel role of red wine-derived polyphenols in the prevention of Alzheimer’s disease dementia and brain pathology: experimental approaches and clinical implications. Planta Med 78:1614–1619
Pastors JC (2003) Medications or lifestyle change with medical nutrition therapy. Curr Diabetes Rep 3(5):386–391
Paterson RRM (2006) Ganoderma - a therapeutic fungal biofactory. Phytochemistry 67:1985–2001
Paterson RRM (2008) Cordyceps: a traditional Chinese medicine and another fungal therapeutic biofactory? Phytochemistry 69(7):1469–1495
Pazarlioglu NK, Akkaya A, Sariisik AM, Erkan G, Kumbasar EPA (2011) Dyeing of wool fibers with natural fungal dye from Suillus luteus. Asian J Chem 23(6):2600–2604
Peng CC, Chen KC, Peng RY, Chyau CC, Su CH, Hsieh-Li HM (2007) Antrodia camphorata extract induces replicative senescence in superficial TCC, and inhibits the absolute migration capability in invasive bladder carcinoma cells. J Ethnopharmacol 109(1):93–103
Percario S, Odorizzi VF, Souza DR, Pinhel MA, Gennari JL, Gennari MS, Godoy MF (2008) Edible mushroom Agaricus sylvaticus can prevent the onset of atheroma plaques in hipercholesterolemic rabbits. Cell Mol Biol 54(Suppl):OL1055–OL1061
Petersen OH, Andras Spät A, Verkhratsky (2005) Introduction: reactive oxygen species in health and disease. Philos Trans R Soc Lond B Biol Sci 360:2197–2199
Petrova RD (2012) New scientific approaches to cancer treatment: can medicinal mushrooms defeat the curse of the century? Int J Med Mushrooms 14(1):1–20
Petrova RD, Wasser SP, Mahajna J, Denchev CM, Nevo E (2005) Potential role of medicinal mushrooms in breast cancer treatment: current knowledge and future perspectives. Int J Med Mushrooms 7:141–155
Petrova RD, Reznick AZ, Wasser SP, Denchev CM, Nevo E, Mahajna J (2008) Fungal metabolites modulating NF-κB activity: an approach to cancer therapy and chemoprevention. Oncol Rep 19:299–308
Petrova R, Mahajna J, Wasser SP, Ruimi N, Denchev CM, Sussan S, Nevo E, Reznick AZ (2009) Marasmius oreades substances block NF-κB activity through interference with IKK activation pathway. Mol Biol Rep 36:737–744
Pham-Huy LA, He H, Pham-Huy C (2008) Free radicals, antioxidants in disease and health. Int J Biomed Sci 4:89–96
Phillips KM, Ruggio DM, Horst RL, Minor B, Simon RR, Feeney MJ, Byrdwell WC, Haytowitz DB (2011a) Vitamin D and sterol composition of 10 types of mushrooms from retail suppliers in the United States. J Agric Food Chem 59(14):7841–7853
Phillips KM, Ruggio DM, Haytowitz DB (2011b) Folate composition of 10 types of mushrooms determined by liquid chromatography– mass spectrometry. Food Chem 129:630–636
Pierson AS, Gibbs P, Richards J, Russ P, Eckhardt SG, Gonzalez R (2002) A phase II study of Irofulven (MGI 114) in patients with stage IV melanoma. Invest New Drugs 20:357–362
Pietsch KE, Neels JF, Yu X, Gong J, Sturla SJ (2011) Chemical and enzymatic reductive activation of acylfulvene to isomeric cytotoxic reactive intermediates. Chem Res Toxicol 24(11):2044–2054
Place AE, Huh SJ, Polyak K (2011) The microenvironment in breast cancer progression: biology and implications for treatment. Breast Cancer Res 13:227. doi:10.1186/bcr2912
Poindessous V, Koeppel F, Raymond E, Cvitkovic E, Waters SJ, Larsen AK (2003) Enhanced antitumor activity of irofulven in combination with 5-fluorouracil and cisplatin in human colon and ovarian carcinoma cells. Int J Oncol 23:1347–1355
Popov D (2011) Novel protein tyrosine phosphatase 1B inhibitors: interaction requirements for improved intracellular efficacy in type 2 diabetes mellitus and obesity control. Biochem Biophys Res Commun 410:377–381
Popova M, Trusheva B, Gyosheva M, Tsvetkova I, Bankova V (2009) Antibacterial triterpenes from the threatened wood-decay fungus Fomitopsis rosea. Fitoterapia 80(5):263–266
Poucheret P, Fons F, Rapior S (2006) Biological and pharmacological activity of higher fungi: 20-year retrospective analysis. Cryptog Mycol 27:311–333
Quang DN, Bach DD, Hashimoto T, Asakawa Y (2006) Chemical constituents of the Vietnamese inedible mushroom Xylaria intracolorata. Nat Prod Res 20(4):317–321
Ramberg JE, Nelson ED, Sinnott RA (2010) Immunomodulatory dietary polysaccharides: A systematic review of the literature. Nutr J 9:54. doi:10.1186/1475-2891-9-54
Ramesh C, Pattar MG (2010) Antimicrobial properties, antioxidant activity and bioactive compounds from six wild edible mushrooms of Western ghats of Karnataka, India. Pharmacognosy Res 2(2):107–112
Rao YK, Wu AT, Geethangili M, Huang MT, Chao WJ, Wu CH, Deng WP, Yeh CT, Tzeng YM (2011) Identification of antrocin from Antrodia camphorata as a selective and novel class of small molecule inhibitor of Akt/mTOR signaling in metastatic breast cancer MDA-MB-231 cells. Chem Res Toxicol 24(2):238–245
Rapior S, Courtecuisse R, Francia C, Siroux Y (2000) Activités biologiques des champignons: recherches actuelles sur les facteurs de risque des maladies cardio-vasculaires. Ann Soc Hort Histoire Nat Hérault 140:26–31
Ravichandran S, Veerasamy R, Raman S, Krishnan PN, Agrawala RK (2008) An overview on HIV-1 reverse transcriptase inhibitors. Digest J Nanomater Biostructures 3(4):171–187
Raymond E, Kahatt C, Rigolet MH, Sutherland W, Lokiec F, Alexandre J, Tombal B, Elman M, Lee MS, MacDonald JR, Cullen M, Misset JL, Cvitkovic E (2004) Characterization and multiparameter analysis of visual adverse events in irofulven single-agent phase I and II trials. Clin Cancer Res 10(22):7566–7574
Reis FS, Pereira E, Barros L, Sousa MJ, Martins A, Ferreira ICFR (2011) Biomolecule profiles in inedible wild mushrooms with antioxidant value. Molecules 16:4328–4338
Ren L, Perera C, Hemar Y (2012) Antitumor activity of mushroom polysaccharides: a review. Food Funct 3(11):1118–1130
Rincão VP, Yamamoto KA, Ricardo NMPS, Soares SA, Meirelles LDP, Nozawa C, Linhares REC (2012) Polysaccharide and extracts from Lentinula edodes: structural features and antiviral activity. Virol J 9:37
Ríos JL, Andújar I, Recio MC, Giner RM (2012) Lanostanoids from fungi: a group of potential anticancer compounds. J Nat Prod 75:2016–2044
Robaszkiewicz A, Bartosz G, Ławrynowicz M, Soszyńsk M (2010) The role of polyphenols, β-carotene, and lycopene in the antioxidative action of the extracts of dried, edible mushrooms. J Nutr Metab 2010:173274. doi:10.1155/2010/173274
Rosen HJ (1975) Mental decline in the elderly: pharmacotherapy (ergot alkaloids versus papaverine).J. Am Geriatr Soc 23(4):169–174
Roupas P, Keogh J, Noakes M, Margetts C, Taylor P (2012) The role of edible mushrooms in health: evaluation of the evidence. J Funct Foods 4:687–709
Rozman D, Komel R (1991) Altered expression of the steroid bioconverting pathway in pAN 7–1 transformants of Cochliobolus lunatus. Curr Genet 20(5):385–389
Ruddon RW (2007) Cancer biology, 4th edn. Oxford University Press, USA
Rumbaugh JA, Nath A (2006) Developments in HIV neuropathogenesis. Curr Pharm Des 12:1023–1044
Salmon DP (2012) Neuropsychological features of mild cognitive impairment and preclinical Alzheimer’s disease. Curr Top Behav Neurosci 10:187–212
Sánchez C (2004) Modern aspects of mushroom culture technology. Appl Microbiol Biotechnol 64:756–762
Sastre M, Klockgether T, Heneka MT (2006) Contribution of inflammatory processes to Alzheimer’s disease: molecular mechanisms. Int J Dev Neurosci 24(2–3):167–176
Sato N, Zhang Q, Ma C-M, Hattori M (2009) Anti-human immunodeficiency virus-1 protease activity of new lanostane- type triterpenoids from Ganoderma sinense. Chem Pharm Bull 57:1076–1080
Schilder RJ, Blessing JA, Shahin MS, Miller DS, Tewari KS, Muller CY, Warshal D, McMeekin DS, Rotmensch J (2010) A phase II evaluation of Irofulven (IND#55804, NSC#683863) as second-line treatment of recurrent or persistent intermediately platinum-sensitive ovarian or primary peritoneal cancer: a Gynecologic Oncology Group trial. Int J Gynecol Cancer 20(7):1137–1141
Schneider I, Kressel G, Meyer A, Krings U, Berger RG, Hahn A (2011) Lipid lowering effects of oyster mushroom (Pleurotus ostreatus) in humans. J Funct Foods 3(1):17–24
Schobert R, Knauer S, Seibt S, Biersack B (2011) Anticancer active illudins: recent developments of a potent alkylating compound class. Curr Med Chem 18(6):790–807
Schüffler A, Anke T (2009) Secondary metabolites of Basidiomycetes. In: Anke T, Weber D (eds) The mycota XV. Springer, Berlin, Heidelberg, New York, pp 209–231
Schüffler A, Wollinsky B, Anke T, Liermann JC, Opatz T (2012) Isolactarane and sterpurane sesquiterpenoids from the basidiomycete Phlebia uda. J Nat Prod 75(7):1405–1408
Schwan WR (2012) Mushrooms: an untapped reservoir for nutraceutical antibacterial applications and antibacterial compounds. Curr Top Nutrac Res 10(1):75–82
Schwan WR, Dunek C, Gebhardt M, Engelbrecht K, Klett T, Monte A, Toce J, Rott M, Volk TJ, LiPuma JJ, Liu XT, McKelvey R (2010) Screening a mushroom extract library for activity against Acinetobacter baumannii and Burkholderia cepacia and the identification of a compound with anti-Burkholderia activity. Ann Clin Microbiol Antimicrob 9:4. doi:10.1186/1476-0711-9-4
Seiden MV, Gordon AN, Bodurka DC, Matulonis UA, Penson RT, Reed E, Alberts DS, Weems G (2006) A phase II study of irofulven in women with recurrent and heavily pretreated ovarian cancer. Gynecol Oncol 101:55–61
Seo JS, Yun JH, Baek IS, Leem YH, Kang HW, Cho HK, Lyu YS, Son HJ, Han PL (2010a) Oriental medicine Jangwonhwan reduces Aβ(1–42) level and β–amyloid deposition in the brain of Tg-APPswe/PS1dE9 mouse model of Alzheimer disease. J Ethnopharmacol 128:206–212
Seo JS, Jung EY, Kim JH, Lyu YS, Han PL, Kang HW (2010b) A modified preparation (LMK03) of the oriental medicine Jangwonhwan reduces Aβ1–42 level in the brain of Tg-APPswe/PS1dE9 mouse model of Alzheimer disease. J Ethnopharmacol 130:578–585
Serova M, Calvo F, Lokiec F, Koeppel F, Poindessous V, Larsen AK, Laar ES, Waters SJ, Cvitkovic E, Raymond E (2006) Characterizations of irofulven cytotoxicity in combination with cisplatin and oxaliplatin in human colon, breast, and ovarian cancer cells. Cancer Chemother Pharmacol 57(4):491–499
Sharma SK, Mohan A (2004) Multidrug-resistant tuberculosis. Indian J Med Res 120:354–376
Shen ZX (2004) Brain cholinesterases: II. The molecular and cellular basis of Alzheimer’s disease. Med Hypotheses 63(2):308–321
Shepard CW, Finelli L, Alter MJ (2005) Global epidemiology of hepatitis C virus infection. Lancet Infect Dis 5(9):558–567
Shi XW, Liu L, Gao JM, Zhang AL (2011) Cyathane diterpenes from Chinese mushroom Sarcodon scabrosus and their neurite outgrowth-promoting activity. Eur J Med Chem 46(7):3112–3117
Shimada Y, Yamakawa A, Morita T, Sugiyama K (2003) Effects of dietary eritadenine on the liver microsomal 1,6-desaturase activity and its mRNA in rats. Biosci Biotechnol Biochem 67:1258–1266
Shimbo M, Kawagishi H, Yokogosh H (2005) Erinacine A increases catecholamine and nerve growth factor content in the central nervous system of rats. Nutr Res 25(6):617–623
Shimoke K, Amano H, Kishi S, Uchida H, Kudo M, Ikeuchi T (2004) Nerve growth factor attenuates endoplasmic reticulum stress-mediated apoptosis via suppression of caspase-12 activity. J Biochem (Tokyo) 135:439–446
Shin S, Lee S, Kwon J, Moon S, Lee S, Lee CK, Cho K, Ha NJ, Kim K (2009) Cordycepin suppresses expression of diabetes regulating genes by inhibition of lipopolysaccharide-induced inflammation in macrophages. Immune Netw 9:98–105
Sies H (1997) Oxidative stress: oxidants and antioxidants. Exp Physiol 82(2):291–295
Silva S, Martins S, Karmali A, Rosa E (2012) Production, purification and characterisation of polysaccharides from Pleurotus ostreatus with antitumour activity. J Sci Food Agric 92(9):1826–1832
Sliva D (2003) Ganoderma lucidum (Reishi) in cancer treatment. Integr Cancer Ther 2:358–364
Sliva D (2010) Medicinal mushroom Phellinus linteus as an alternative cancer therapy (Review). Exp Ther Med 1:407–411
Smith D, Ryan MJ (2009) Fungal sources for new drug discovery. In Access Science, ©McGraw-Hill Companies http://www.accessscience.com
Smith MA, Rottkamp CA, Nunomura A, Raina AK, Perry G (2000) Oxidative stress in Alzheimer’s disease. Biochim Biophys Acta 1502:139–144
Smith KJ, Pagé V, Gariépy G, Béland M, Badawi G, Schmitz N (2012) Self-rated diabetes control in a Canadian population with type 2 diabetes: associations with health behaviours and outcomes. Diabetes Res Clin Pract 95:162–168
Song TY, Yen GC (2002) Antioxidant properties of Antrodia camphorata in submerged culture. J Agric Food Chem 50:3322–3327
Song Y, Hui J, Kou W, Xin R, Jia F, Wang N, Hu F, Zhang H, Liu H (2008) Identification of Inonotus obliquus and analysis of antioxidation and antitumor activities of polysaccharides. Curr Microbiol 57:454–462
Spano JP, Carcelain G, Katlama C, Costagliola D (2006) Non-AIDS defining malignancies in HIV patients: clinical features and perspectives. Bull Cancer 93:37–42
Standish LJ, Wenner CA, Sweet ES, Bridge C, Nelson A, Martzen M, Novack J, Torkelson C (2008) Trametes versicolor mushroom immune therapy in breast cancer. J Soc Integr Oncol 6:122–128
Stanikunaite R, Radwan MM, Trappe JM, Fronczek F, Ross SA (2008) Lanostane-type triterpenes from the mushroom Astraeus pteridis with antituberculosis activity. J Nat Prod 71(12):2077–2079
Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL (1989) Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med 320:915–924
Strohl WR (2000) The role of natural products in a modern drug discovery program. Drug Discov Today 5:39–41
Sugiyama K, Akachi T, Yamakawa A (1995) Eritadenine-induced alteration of hepatic phospholipid metabolism in relation to its hypocholesterolemic action in rats. J Nutr Biochem 6:80–87
Sullivan R, Smith JE, Rowan NJ (2006) Medicinal mushrooms and cancer therapy: translating a traditional practice into Western medicine. Perspect Biol Med 49(2):159–170
Sun JE, Ao ZH, Lu ZM, Xu HY, Zhang XM, Dou WF, Xu ZH (2008) Antihyperglycemic and antilipidperoxidative effects of dry matter of culture broth of Inonotus obliquus in submerged culture on normal and alloxan-diabetes mice. J Ethnopharmacol 118(1):7–13
Synytsya A, Novák M (2013) Structural diversity of fungal glucans. Carbohydr Polym 92(1):792–809
Taji S, Yamada T, In Y, Wada S, Usami Y, Sakuma K, Tanaka R (2007) Three new lanostane triterpenoids from Inonotus obliquus. Helv Chim Acta 90:2047–2057
Taji S, Yamada T, Tanaka R (2008a) Three new lanostane triterpenoids, inonotsutriols A, B, and C from Inonotus obliquus. Helv Chim Acta 91:1513–1524
Taji S, Yamada T, Wada S, Tokuda H, Sakuma K, Tanaka R (2008b) Lanostanetype triterpenoids from the sclerotia of Inonotus obliquus possessing anti-tumor promoting activity. Eur J Med Chem 43:2373–2379
Tanaka R, Toyoshima M, Yamada T (2011) New lanostane triterpenoids, inonotsutriols D, and E from Inonotus obliquus. Phytochem Lett 4(3):329–332
Tang W, Gu T, Zhong JJ (2006a) Separation of targeted ganoderic acids from Ganoderma lucidum by reversed phase liquid chromatography with ultraviolet and mass spectrometry detections. Biochem Eng J 32:205–210
Tang W, Liu JW, Zhao WM, Wei DZ, Zhong JJ (2006b) Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells. Life Sci 80:205–211
Tang YZ, Zhu LW, Li HM, Li DS (2007) Submerged culture of mushrooms in bioreactors challenges, current-state-of-the-art, and future. Food Technol Biotechnol 45:221–229
Teng BS, Wang CD, Yang HJ, Wu JS, Zhang D, Zheng M, Fan ZH, Pan D, Zhou P (2011) A protein tyrosine phosphatase 1B activity inhibitor from the fruiting bodies of Ganoderma lucidum (Fr.) Karst and its hypoglycemic potency on streptozotocin-induced type 2 diabetic mice. J Agric Food Chem 59:6492–6500
Teng BS, Wang CD, Zhang D, Wu JS, Pan D, Pan LF, Yang HJ, Zhou P (2012) Hypoglycemic effect and mechanism of a proteoglycan from Ganoderma lucidum on streptozotocin-induced type 2 diabetic rats. Eur Rev Med Pharmacol Sci 16:166–175
Teplyakova TV, Psurtseva NV, Kosogova TA, Mazurkova NA, Khanin VA, Vlasenko VA (2012) Antiviral activity of polyporoid mushrooms (higher Basidiomycetes) from Altai Mountains (Russia). Int J Med Mushrooms 14(1):37–45
Tepwong P, Giri A, Sasaki F, Fukui R, Ohshima T (2012) Mycobial enhancement of ergothioneine by submerged cultivation of edible mushroom mycelia and its application as an antioxidative compound. Food Chem 131(1):247–258
Thetsrimuang C, Khammuang S, Sarnthima R (2011) Antioxidant activity of crude polysaccharides from edible fresh and dry mushroom fruiting bodies of Lentinus sp. strain RJ-2. Int J Pharmacol 7:58–65
Thyagarajan-Sahu A, Lane B, Sliva D (2011) ReishiMax, mushroom based dietary supplement, inhibits adipocyte differentiation, stimulates glucose uptake and activates AMPK. BMC Complement Altern Med 11:74. doi:10.1186/1472-6882-11-74
Tourlouki E, Matalas AL, Panagiotakos DB (2009) Dietary habits and cardiovascular disease risk in middle-aged and elderly populations: a review of evidence. Clin Interv Aging 4:319–330
Trincone A, Pagnotta E, Tramice A (2012) Enzymatic routes for the production of mono- and di-glucosylated derivatives of hydroxytyrosol. Bioresour Technol 115:79–83
Tsao R (2010) Chemistry and biochemistry of dietary polyphenols. Nutrients 2:1231–1246
Tu SH, Wu CH, Chen LC, Huang CS, Chang HW, Chang CH, Lien HM, Ho YS (2012) In vivo antitumor effects of 4,7-dimethoxy-5-methyl-1,3-benzodioxole isolated from the fruiting body of Antrodia camphorata through activation of the p53-mediated p27/Kip1 signaling pathway. J Agric Food Chem 60:3612–3618
Turkoglu A, Duru ME, Mercan N, Kivrak I, Gezer K (2007) Antioxidant and antimicrobial activities of Laetiporus sulphureus (Bull.) Murrill. Food Chem 101(1):267–273
Ueda K, Tsujimori M, Kodani S, Chiba A, Kubo M, Masuno K, Sekiya A, Nagai K, Kawagishi H (2008) An endoplasmic reticulum (ER) stress-suppressive compound and its analogues from the mushroom Hericium erinaceum. Bioorg Med Chem 16:9467–9470
Ulziijargal E, Mau JL (2011) Nutrient compositions of culinarymedicinal mushroom fruiting bodies and mycelia. Int J Med Mushrooms 13:343–349
Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M (2006) Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 160(1):1–40
Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J (2007) Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39(1):44–84
Velíšek J, Cejpek K (2011) Pigments of higher fungi: a review. Czech J Food Sci 29(2):87–102
Volman JJ, Mensink RP, van Griensven LJ, Plat J (2010) Effects of alpha-glucans from Agaricus bisporus on ex vivo cytokine production by LPS and PHA-stimulated PBMCs; a placebo-controlled study in slightly hypercholesterolemic subjects. Eur J Clin Nutr 64(7):720–726
Wachtel-Galor S, Tomlinson B, Benzie FF (2004) Ganoderma lucidum (‘Lingzhi’), a Chinese medicinal mushroom: biomarker responses in a controlled human supplementation study. Br J Nutr 91:263–269
Wang Y, Mo SY, Wang SJ, Li S, Yang YC, Shi JG (2005) A unique highly oxygenated Pyrano[4,3-c][2]benzopyran-1,6-dione derivative with antioxidant and cytotoxic activities from the fungus Phellinus igniarius. Org Lett 7(9):1675–1678
Wang J, Wang HX, Ng TB (2007a) A peptide with HIV-1 reverse transcriptase inhibitory activity from the medicinal mushroom Russula paludosa. Peptides 28(3):560–565
Wang Y, Shang XY, Wang SJ, Mo SY, Li S, Yang YC, Ye F, Shi JG, Lan H (2007b) Structures, biogenesis, and biological activities of Pyrano[4,3-c]isochromen-4-one derivatives from the fungus Phellinus igniarius. J Nat Prod 70:296–299
Wang S, Meckling KA, Marcone MF, Kakuda Y, Tsao R (2011) Can phytochemical antioxidant rich foods act as anti-cancer agents? Food Res Int 44:2545–2554
Wang Y, Bao L, Liu D, Yang X, Li S, Gao H, Yao X, Wen H, Liu H (2012a) Two new sesquiterpenes and six norsesquiterpenes from the solid culture of the edible mushroom Flammulina velutipes. Tetrahedron 68:3012–3018
Wang Y, Bao L, Yang X, Li L, Li S, Gao H, Yao XS, Wen H, Liu HW (2012b) Bioactive sesquiterpenoids from the solid culture of the edible mushroom Flammulina velutipes growing on cooked rice. Food Chem 132:1346–1353
Wang LC, Wang SE, Wang JJ, Tsai TY, Lin CH, Pan TM, Lee CL (2012c) In vitro and in vivo comparisons of the effects of the fruiting body and mycelium of Antrodia camphorata against amyloid β-protein-induced neurotoxicity and memory impairment. Appl Microbiol Biotechnol 94(6):1505–1519
Waris G, Ahsan H (2006) Reactive oxygen species: role in the development of cancer and various chronic conditions. J Carcinog 5:14. doi:10.1186/1477-3163-5-14
Wasser SP (2011) Current findings, future trends, and unsolved problems in studies of medicinal mushrooms. Appl Microbiol Biotechnol 89:1323–1332
Watanabe K, Shuto T, Sato M, Onuki K, Mizunoe S, Suzuki S, Sato T, Koga T, Suico MA, Kai H, Ikeda T (2011) Lucidenic acids-rich extract from antlered form of Ganoderma lucidum enhances TNFα induction in THP-1 monocytic cells possibly via its modulation of MAP kinases p38 and JNK. Biochem Biophys Res Commun 408(1):18–24
Wawrzyn GT, Quin MB, Choudhary S, López-Gallego F, Schmidt-Dannert C (2012a) Draft genome of Omphalotus olearius provides a predictive framework for sesquiterpenoid natural product biosynthesis in Basidiomycota. Chem Biol 19(6):772–783
Wawrzyn GT, Bloch SE, Schmidt-Dannert C (2012b) Discovery and characterization of terpenoid biosynthetic pathways of fungi. Methods Enzymol 515:83–105
Wei S, Helsper JPFG, Van Griensven LJLD (2008) Phenolic compounds present in medicinal mushroom extracts generate reactive oxygen species in human cells in vitro. Int J Med Mushrooms 10(1):1–13
Wells TNC, Alonso PL, Gutteridge WE (2009) New medicines to improve control and contribute to the eradication of malaria. Nat Rev Drug Discov 8:879–891
Wender PA, Baryza JL, Brenner SE, DeChristopher BA, Loy BA, Schrier AJ, Verma VA (2011) Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity. PNAS 108(17):6721–6726
Weng CJ, Yen GC (2010) The in vitro and in vivo experimental evidences disclose the chemopreventive effects of Ganoderma lucidum on cancer invasion and metastasis. Clin Exp Metastasis 27:361–369
Weng CJ, Chau CF, Chen KD, Chen DH, Yen GC (2007) The anti-invasive effect of lucidenic acids isolated from a new Ganoderma lucidum strain. Mol Nutr Food Res 51(12):1472–1477
WHO (2011) World Health Organization. Diabetes program http://www.who.int/mediacentre/factsheets/fs312/en/
Wiater A, Paduch R, Choma A, Pleszczyńska M, Siwulski M, Dominik J, Janusz G, Tomczyk M, Szczodrak J (2012) Biological study on carboxymethylated (1 → 3)-α-d-glucans from fruiting bodies of Ganoderma lucidum. Int J Biol Macromol 51:1014–1023
Wiemann P, Albermann S, Niehaus EM, Studt L, von Bargen KW, Brock NL, Humpf HU, Dickschat JS, Tudzynski B (2012) The Sfp-Type 4′-Phosphopantetheinyl transferase Ppt1 of Fusarium fujikuroi controls development, secondary metabolism and pathogenicity. PLoS ONE 7(5):e37519
Wild S, Roglic F, Green A, Sucree R, King H (2004) Global prevalence of diabetes: estimated for the year 2000 and projections for 2030. Diabetes Care 27:1047–1053
Wiltshire T, Senft J, Wang Y, Konat GW, Wenger SL, Reed E, Wang W (2007) BRCA1 contributes to cell cycle arrest and chemoresistance in response to the anticancer agent irofulven. Mol Pharmacol 71(4):1051–1060
Wisitrassameewong K, Karunarathna SC, Thongklang N, Zhao RL, Callac P, Chukeatirote E, Bahkal AH, Hyde KD (2012a) Agaricus subrufescens: new to Thailand. Chiang Mai J Sci 39(2):281–291
Wisitrassameewong K, Karunarathna SC, Thongklang N, Zhao RL, Callac P, Moukha S, Ferandon C, Chukeatirote E, Hyde KD (2012b) Agaricus subrufescens: a review. Saudi J Biol Sci 19(2):131–146
Wong YY, Moon A, Duffin R, Barateig AB, Meijer HA, Clemens MJ, de Moor CH (2010) Cordycepin inhibits protein synthesis and cell adhesion through effects on signal transduction. J Biol Chem 285:2610–2621
Wongsa P, Tasanatai K, Watts P, Hywel-Jones N (2005) Isolation and in vitro cultivation of the insect pathogenic fungus Cordyceps unilateralis. Mycol Res 109(Pt 8):936–940
Woo MH, Peterson JK, Billups C, Liang H, Bjornsti MA, Houghton PJ (2005) Enhanced antitumor activity of irofulven in combination with irinotecan in pediatric solid tumor xenograft models. Cancer Chemother Pharmacol 55:411–419
Woolston BM, Schlagnhaufer C, Wilkinson J, Larsen J, Shi Z, Mayer KM, Walters DS, Curtis WR, Romaine CP (2011) Long-distance translocation of protein during morphogenesis of the fruiting body in the filamentous fungus, Agaricus bisporus. PLoS ONE 6(12):e28412
Woynarowski J, Napier C, Koester S (1997) Effects on DNA integrity and apoptosis induction by a novel antitumor sesquiterpene drug, 6-hydroxymethylacylfulvene (HMAF). Biochem Pharmacol 54:1181–1193
Wu GS, Lu JJ, Guo JJ, Li YB, Tan W, Dang YY, Zhong ZF, Xu ZT, Chen XP, Wang YT (2012) Ganoderic acid DM, a natural triterpenoid, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Fitoterapia 83(2):408–414
Xu K, Liang X, Gao F, Zhong J, Liu J (2010) Antimetastatic effect of ganoderic acid T in vitro through inhibition of cancer cell invasion. Process Biochem 45:1261–1267
Xu X, Wu Y, Chen H (2011) Comparative antioxidative characteristics of polysaccharide-enriched extracts from natural sclerotia and cultured mycelia in submerged fermentation of Inonotus obliquus. Food Chem 127:74–79
Xu X, Yan H, Zhang X (2012a) Structure and immuno-stimulating activities of a new heteropolysaccharide from Lentinula edodes. J Agric Food Chem 60(46):11560–11566
Xu TT, Beelman RB, Lambert JD (2012b) The cancer preventive effects of edible mushrooms. Anticancer Agents Med Chem 12(10):1255–1263
Yang RL, Li N, Li RF, Smith TJ, Zong MH (2010) A highly regioselective route to arbutin esters by immobilized lipase from Penicillium expansum. Bioresour Technol 101:1–5
Yang HL, Kuo YH, Tsai CT, Huang YT, Chen SC, Chang HW, Lin E, Lin WH, Hseu YC (2011) Anti-metastatic activities of Antrodia camphorata against human breast cancer cells mediated through suppression of the MAPK signaling pathway. Food Chem Toxicol 49(1):290–298
Yang XF, Luedeling K, Chen GL, Hyde KD, Yang YJ, Zhou DQ, Xu JC, Yang YP (2012) Climate change effects fruiting of the prize matsutake mushroom in China. Fungal Divers 56:189–198
Yang TK, Lee YH, Paudel U, Bhattarai G, Yun BS, Hwang PH, Yi HK (2013) Davallialactone from mushroom reduced premature senescence and inflammation on glucose oxidative stress in human diploid fibroblast cells. J Agric Food Chem 61(29):7089–7095
Yao X, Li G, Xu H (2012) Chaotian Lü1inhibition of the JAK-STAT3 signaling pathway by ganoderic acid A enhances chemosensitivity of HepG2 cells to Cisplatin. Planta Med 78:1740–1748
Yeh CT, Rao YK, Yao CJ, Yeh CF, Li CH, Chuang SE, Luong JH, Lai GM, Tzeng YM (2009) Cytotoxic triterpenes from Antrodia camphorata and their mode of action in HT-29 human colon cancer cells. Cancer Lett 285(1):73–79
Ying J, Mao X, Ma Q, Zong Y, Wen H (1987) Icones of medicinal fungi from China (translated, Yuehan X). Science Press, Beijing, 575 p
Yoon KN, Alam N, Lee JS, Cho HJ, Kim HY, Shim MJ, Lee MW, Lee TS (2011) Antihyperlipidemic effect of dietary Lentinula edodes on plasma, feces and hepatic tissues in hypercholesterolemic rats. Mycobiology 39(2):96–102
Yoshikawa N, Nakamura K, Yamaguchi Y, Kagota S, Shinozuka K, Kunitomo M (2004) Antitumour activity of cordycepin in mice. Clin Exp Pharmacol Physiol 31(2):S51–S53
Youn MJ, Kim JK, Park SY, Kim Y, Park C, Kim ES, Park KI, So HS, Park R (2009) Potential anticancer properties of the water extract of Inonotus obliquus by induction of apoptosis in melanoma B16-F10 cells. J Ethnopharmacol 121(2):221–228
Young SN (2013) Single treatments that have lasting effects: some thoughts on the antidepressant effects of ketamine and botulinum toxin and the anxiolytic effect of psilocybin. J Psychiatry Neurosci 38(2):78–83
Yu CC, Chiang PC, Lu PH, Kuo MT, Wen WC, Chen P, Guh JH (2012) Antroquinonol, a natural ubiquinone derivative, induces a cross talk between apoptosis, autophagy and senescence in human pancreatic carcinoma cells. J Nutr Biochem 23(8):900–907
Yue PY, Wong YY, Chan TY, Law CK, Tsoi YK, Leung KS (2012) Review of biological and pharmacological activities of the endemic Taiwanese bitter medicinal mushroom, Antrodia camphorata (M. Zang et C. H. Su) Sh. H. Wu et al. (higher Basidiomycetes). Int J Med Mushrooms 14(3):241–256
Zahid S, Udenigwe CC, Ata A, Eze MO, Segstro EP, Holloway P (2006) New bioactive natural products from Coprinus micaceus. Nat Prod Res 20(14):1283–1289
Zaidman BZ, Yassin M, Mahajna J, Wasser SP (2005) Medicinal mushroom modulators of molecular targets as cancer therapeutics. Appl Microbiol Biotechnol 67:453–468
Zhang G, Huang Y, Bian Y, Wong JH, Ng TB, Wang H (2006) Hypoglycemic activity of the fungi Cordyceps militaris, Cordyceps sinensis, Tricholoma mongolicum and Omphalia lapidescens in streptozotocin-induced diabetic rats. Appl Microbiol Biotechnol 72:1152–1156
Zhang M, Cui SW, Cheung PCK, Wang Q (2007) Anti-tumor polysaccharides from mushrooms: a review on their isolation, structural characteristics and antitumor activity. Trends Food Sci Technol 18:4–19
Zhang ZC, Lian B, Huang DM, Cui FJ (2009) Compare activities on regulating lipid-metabolism and reducing oxidative stress of diabetic rats of Tremella aurantialba broth’s extract (TBE) with its mycelia polysaccharides (TMP). J Food Sci 74(1):H15–H21
Zhao JD (1998) Flora Fungorum sinicorum. Polyporaceae. Vol. 3. Science Press, Beijing, pp 186–187
Zhao RI, Desjardin DE, Soytong K, Perry BA, Hyde KD (2010) A monograph of Micropsalliota in Northern Thailand based on morphological and molecular data. Fungal Divers 45:33–79
Zhao RL, Karunarathna SC, Raspé O, Parra LA, Guinberteau J, Moinard M, De Kesel A, Barroso G, Desjardin D, Courtecuisse R, Hyde KD, Guelly AK, Callac P (2011) Major clades in tropical Agaricus. Fungal Divers 51:279–296
Zheng W, Miao K, Liu Y, Zhao Y, Zhang M, Pan S, Dai Y (2010) Chemical diversity of biologically active metabolites in the sclerotia of Inonotus obliquus and submerged culture strategies for up-regulating their production. Appl Microbiol Biotechnol 87(4):1237–1254
Zheng W, Zhao Y, Zheng X, Liu Y, Pan S, Dai Y, Liu F (2011) Production of antioxidant and antitumor metabolites by submerged cultures of Inonotus obliquus cocultured with Phellinus punctatus. Appl Microbiol Biotechnol 89(1):157–167
Zhong JJ, Xiao JH (2009) Secondary metabolites from higher fungi: discovery, bioactivity, and bioproduction. Adv Biochem Eng Biotechnol 113:79–150
Zhou ZY, Liu JK (2010) Pigments of fungi (macromycetes). Nat Prod Rep 27:1531–1570
Zhou L, Shi P, Chen NH, Zhong JJ (2011) Ganoderic acid Me induces apoptosis through mitochondria dysfunctions in human colon carcinoma cells. Process Biochem 46:219–225
Zhu YC, Wang G, Yang XL, Luo DQ, Zhu QC, Peng T, Liu JK (2010) Agrocybone, a novel bis-sesquiterpene with a spirodienone structure from basidiomycete Agrocybe salicacola. Tetrahedr Lett 51:3443–3445
List of patents
Beelman RB, Dubost NJ, Peterson DG, Hausman M (2007) Phytonutrient compositions from mushrooms or filamentous fungi comprising ergothioneine for treatment of neurodegenerative diseases and radiation damage Database: CAPLUS. WO 2007106859 A2 20070920
Berglund KA, Rova U, Enman J (2011) Method for producing eritadenine in liquid phase fermentation. US 8053217
Grothe T, Stadler M, Köpcke B, Roemer E, Bitzer J, Wabnitz P (2012) Terpenoid spiro ketal compounds with LXR agonists activity, their use and formulations with them. EP2468253 A1
Liu Z, Cang L, Chen C, Zhou G (2008) Method for preparing gold needle mushroom canned food for decreasing blood sugar and adjusting blood fat Database: CAPLUS. CN 101292726 A 20081029
Takeshi I, Hiroshi H, Satoshi I, Aya K (2012) Mushroom extracts from Agaricus, Hericium erinaceum, and Hypsizigus marmoreus as insulin secretion stimulators and health foods for prevention and therapy of diabetes mellitus. JP 2012077004A
Zhong J, Liu R, Li Y (2011) Ganoderic acid T amide derivative TLTO-A and synthetic method and application thereof Database: CAPLUS. CN 102219822 A 20111019
Zhuang C, Kawagishi H, Zhang L, Anzai H (2009) Anti-dementia substance from Hericium erinaceum and method of extraction Database: CAPLUS. US 20090274720 A1 20091105
Acknowledgments
This study was supported by the grant of the 1551 French-Thai cooperation PHC SIAM 2011 (project 25587RA) and the Mae Fah Luang University funded grant “Taxonomy, Phylogeny and cultivation of Lentinus species in northern Thailand” (MFU/54 1 01 02 00 48); and this study was financially supported by the project “Value added products from basidiomycetes: Putting Thailand’s biodiversity to use” (BRN049/2553) by the National Research Council of Thailand (NRCT) to study medicinal fungi; the National Research Council of Thailand (NRCT), project - Taxonomy, Phylogeny and cultivation of Lentinus species in northern Thailand (NRCT/55201020007); and the Thailand Research Fund grant - Taxonomy, Phylogeny and biochemistry of Thai Basidiomycetes (BRG 5580009). The authors would also like to acknowledge University Malaya research grants: CG037-2013 Phylogeny, taxonomy, relationships and biotechnological potential of sooty moulds and RG203-12SUS Isolation and structural elucidation of anti-microbial compounds for saprophytic and endophytic fungi of Peninsular Malaysia through bioassay guided fractionation of secondary metabolites extract.
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De Silva, D.D., Rapior, S., Sudarman, E. et al. Bioactive metabolites from macrofungi: ethnopharmacology, biological activities and chemistry. Fungal Diversity 62, 1–40 (2013). https://doi.org/10.1007/s13225-013-0265-2
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DOI: https://doi.org/10.1007/s13225-013-0265-2