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Embryonic Stem Cells: Discovery, Development, and Current Trends

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Stem Cells & Regenerative Medicine

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Murine embryonic stem cells were first derived almost 30 years ago from cultured blastocysts and have been primarily used as a tool to better understand development through targeted gene deletions. Only recently has the focus has shifted toward embryonic stem cells themselves and the molecular mechanisms by which they choose a specific cell fate. Through rapid advances in cell culture and genomic modification techniques researchers are beginning to regularly utilize embryonic stem cells for in vitro gene function assays. More important, the mechanisms critical for establishing the pluripotent sate of embryonic stem cells have been elucidated to the point that clinically beneficial stem cell–like counterparts can now be generated from nonembryonic sources.

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  1. Department of Genetics, Stanford University School of Medicine, MC: 5120, 300 Pasteur Dr., M-344, Stanford, CA, 94305-2200, USA

    Michael Snyder

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Theodorou, E., Snyder, M. (2011). Embryonic Stem Cells: Discovery, Development, and Current Trends. In: Appasani, K., Appasani, R. (eds) Stem Cells & Regenerative Medicine. Stem Cell Biology and Regenerative Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-860-7_2

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